原著論文＜大泉康＞

• 1.Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei
  Guo, Y., Xu, J., Li, Y., Watanabe, R., Oshima, Y., Yamakuni, T. & Ohizumi, Y.
  Chem. Pharm. Bull., 54, 123-125 (2006)
• 2.Garcinone B reduces prostaglandin E2 release and NF-κB-mediated transcription in C6 cells
  Yamakuni, T., Aoki, K., Nakatani, K., Kondo, N., Oku, H., Ishiguro, K. & Ohizumi, Y.
  Neurosci. Lett., 394, 206-210 (2006)
• 3.Three-membered ring sesquiterpenoids with NGF-potentiating activity from the roots of Valeriana fauriei
  Guo, Y., Xu, J., Li, Y., Yamakuni, T. & Ohizumi, Y.
  Planta Med., 72, 373-375 (2006)
• 4.Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana
  Guo, Y., Li, Y., Xu, J., Watanabe, R., Oshima, Y., Yamakuni, T. & Ohizumi, Y.
  J. Nat. Prod., 69, 274-276 (2006)
• 5.Metronomic scheduling of a cyclic hexapeptide Ra-VII for anti-angiogenesis, tumor vessel maturation, and anti-tumor activity
  Koizumi, T., Abe, M., Yamakuni, T., Ohizumi, Y., Hitotsuyanagi, Y., Takeya, K. & Sato, Y.
  Cancer Sci., 97, 665-674 (2006)
• 6.Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats
  Ono, Y., Hattori, E., Fukaya, Y., Imai, S. & Ohizumi, Y.
  J. Ethnopharmacol., 106, 238-244 (2006)
• 7.Nobiletin restoring β-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats
  Matsuzaki, K., Yamakuni, T., Hashimoto, M., Haque, A. M., Shido, O., Mimaki, Y., Sashida, Y. & Ohizumi, Y.
  Neurosci. Lett., 400, 230-234 (2006)
• 8.Ca2+ channel activating action of maitotoxin in cultured brainstem neurons
  Kakizaki, A., Takahashi, M., Akagi, H., Tachikawa, E., Yamamoto, T., Taira, E., Yamakuni, T., & Ohizumi, Y.
  Eur. J. Pharmacol., 536, 223-231 (2006)
• 9.Proinsulin C-peptide stimulates a PKC/IκB/NF-κB signaling pathway to activate COX-2 gene transcription in Swiss 3T3 fibroblasts
  Kitazawa, M., Shibata, Y., Hashimoto, S., Ohizumi, Y. & Yamakuni, T.
  J. Biochem. 139, 1083-1088 (2006)
• 10.V-1 enhances PMA-induced activation of NF-κB-dependent transcription in PC12D cells
  Hiwatashi, Y., Yamakuni, T. & Ohizumi, Y.
  Pharmacometrics, 70, 17-20 (2006)
• 11.Stimulatory action of eudistomin analogues on the ATPase activity of skeletal muscle myosin B
  Seino-Umeda, A., Kobayashi, J. & Ohizumi, Y.
  Pharmacometrics, 70, 21-23 (2006)
• 12.Stimulatory action of eudistomin D analogues on the contractile protein system of skeletal muscle
  Seino-Umeda, A., Kobayashi, J. & Ohizumi, Y.
  Pharmacometrics, 70, 25-27 (2006)
• 13.Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine
  via activation of epsilon isoform of protein kinase C
  Saito, M., Hori, M., Obara, Y., Ohizumi, Y., Ohkubo, S. & Nakahata N.
  Eur. J. Pharm. Sci., 28, 263-271 (2006)
• 14.Uncaria rhynchophylla, a Chinese medicial herb, has potent antiaggregation effects on Alzheimer’s β-amyloid proteins
  Fujiwara, H., Iwasaki, K., Furukawa, K., Seki, T., He, M., Maruyama, M., Tomita, N., Kudo, Y., Higuchi, M., Saido, T.C., Maeda, S.,
  Takashima, A., Hara, M., Ohizumi, Y. & Arai, H.
  J. Neurosci. Res., 84, 427-433 (2006)
• 15.Participation of epoxygenase activation in saikogenin D-induced inhibition of prostagladin E2 synthesis
  Toriniwa, Y., Lv X., Kodama, Y., Ohizumi, Y., Yoshida, M. & Nakahata, N.
  J. Pharm. Pharmacol., 58, 859-866 (2006)
• 16.Molecular and electrophysiological characteristics of K+ conductance sensitive to acidic pH in aortic smooth muscle cells of WKY
  and SHR
  Kiyoshi, H., Yamazaki, D., Ohya, S., Kitsukawa, M., Muraki, K., Saito, S., Ohizumi, Y. & Imaizumi, Y.
  Am. J. Physiol. Heart Circ. Physiol., 291, H2723-2734 (2006)
• 17.Ephedrae herba (Mao) decreased histamine content in RBL-2H3 cells
  Saito, S., Kamiyama, S. & Ohizumi, Y.
  J. Nat. Med., 60, 225-230 (2006)
• 18.Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by
  activation of extracellular signal-regulated kinase signaling
  Nakajima, A., Yamakuni, T., Matsuzaki, K., Nakata, N., Onozuka, H., Yokosuka, A., Sashida, Y., Mimaki, Y. & Ohizumi, Y.
  J. Pharmacol. Exp. Ther., 321, 784-790 (2007)
• 19.Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in
  mice
  Nakajima, A., Yamakuni, T., Haraguchi, M., Omae, N., Young Song,S., Kato, C., Nakagawasai, O., Tadano, T., Yokosuka, A.,
  Mimaki, Y., Sashida, Y. & Ohizumi, Y.
  J. Pharmacol. Sci., 105, 122-126 (2007)
• 20.Angiopoietin-related growh factor suppresses gluconeogenesis through the akt/forkhead box class O1-dependent pathway in
  hepatocytes
  Kitazawa, M., Ohizumi, Y., Oike, Y., Hishinuma, T. & Hashimoto, S.
  J.Pharmacol. Exp. Ther., 323, 787-793 (2007)
• 21.Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana
  Guo, Y., Li, Y., Xu, J., Li, N., Yamakuni, T. & Ohizumi, Y.
  Chem.Pharm.Bull., 55, 1532-1534 (2007)
• 22.Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor
  subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus
  Matsuzaki, K., Miyazaki, K., Sakai, S., Yawo, H., Nakata, N., Moriguchi, S., Fukunaga, K., Yokosuka, A., Sashida, Y., Mimaki, Y.,
  Yamakuni T. & Ohizumi, Y.
  Eur. J. Pharmacol., 578, 194-200 (2008)
• 23.Dual action of palytoxin in the isolated hypogastriic nerve-vas deferens preparation of guinea-pigs
  Ohizumi, Y.
  Pharmacometrics, 74, 27-31 (2008)
• 24.A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates
  phosphorylation of ERK and CREB in cultured rat cortical neurons
  Rahim, Md. Al., Nakajima, A., Misawa, N., Shindo, K., Adachi, K., Shizuri, Y., Ohizumi, Y. & Yamakuni, T.
  Pharmacometrics, 74, 131-135 (2008)
• 25.Nobiletin, a citrus flavonoid, improves memory impairment and Ab pathology in a transgenic mouse model of Alzheimer’s disease
  Onozuka, H., Nakajima, A., Matsuzaki, K., Shin, RW., Ogino, K., Saigusa, D., Tetsu, N., Yokosuka, A., Sashida, Y., Mimaki, Y.,
  Yamakuni, T. & Ohizumi, Y.
  J. Pharmacol. Exp. Ther., 326, 739-744 (2008)
• 26.Shishihakuhito, a kampo medicine for atopic dermatitis, preventslipopolysaccharideinduced
  activation of NF-kB-dependent transcription in C6 rat glioma cells
  Aoki, K., Yoshida, M., Ohizumi, Y. & Yamakuni, T.
  Pharmacometrics, 74, 107-110 (2008)
• 27.A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates
  PKA/MEK/ERK signaling and antagonizes Ab-inhibition of the cascade in cultured rat CNS neurons
  Rahim, Md. Al., Nakajima, A., Misawa, N., Shindo, K., Adachi, K., Shizuri, Y., Ohizumi, Y. & Yamakuni, T.
  Eur. J. Pharmacol., 600, 10-17 (2008)
• 28.Shishihakuhito, a traditional Chinese medicine for atopic dermatitis inhibits
  IgE-mediated histamine release from rat RBL-2H3 basophilic leukocyte cells
  Wakabayashi, M., Sakurai, E., Yanai, K., Umemura, K., Yoshida, K., Ohizumi, Y. & Yamakuni, T.
  J.Trad.Med., 26(1), 44-49 (2009)
• 29.Honeybee royal jelly stimulates CRE-mediated transcription in a PKA-but not
  MEK/ERK-dependent manner in PC12D cells
  Yamaguchi, K., Kogure, A., Murata, K., Hitomi, N., Nakajima, A., Yamakuni, T. & Ohizumi, Y.
  Pharmacometrics, 76, 33-38 (2009)
• 30.Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB
  phosphorylation
  Yamamoto Y., Shioda N., Han F., Moriguchi S., Nakajima A., Yokosuka A., Mimaki Y., Sashida Y., Yamakuni T., Ohizumi Y. &
  Fukunaga K.
  Brain Res., 1292, 218-229 (2009)
• 31.4’-Demethlynobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment
  associated with NMDA receptor antagonism via stimulation of the ERK cascade
  Md. Al Rahim, Nakajima A., Saigusa D., Tetsu N., Maruyama Y., Shibuya, M., Yamakoshi H., Tomioka Y., Iwabuchi Y.,
  Ohizumi Y. & Yamakuni T.
  Biochemistry, 48, 7713-7721 (2009)
• 32.Search for herbal extracts with the activity to stimulate tyrosine hydroxylase gene transcription in PC12D cells
  Tagaya, S., Suetake, Y., Yoshida, K., Shimura, S., Ohizumi, Y., & Yamakuni, T.
  Pharmacometrics, 77, 131-135 (2009)
• 33.High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and
  serum of mice administrated the natural compound
  Saigusa, D., Shibuya, M., Jinno, D., Yamakoshi, H., Iwabuchi, Y., Yokosuka, A., Mimaki, Y.,
  Naganuma, A., Ohizumi, Y., Tomioka, Y. & Yamakuni, T.
  Anal. Bioanal. Chem. 400, 3635-3641 (2011)
• 34.Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and dependent fashion respectively,
  In PC12D cells
  Fujiwara, H. , Kogure, A., Sakamoto, M., Yamakuni,T., Mimamki,Y.,Murata,K., Hitomi,N. ,
  Yamaguchi,K., & Ohizumi,Y.
  J. Pharmacol. Sci., in press.
• 35.Inhibitory effects of citrus polymethoxyflavones, nobiletin and its analogues, on
  acetylcholinesterase activity
  Kimura, J., Nemoto, K., Onoue, S., Yamakuni, T., Yokosuka, A.
  Mimaki, Y., Yamada, S., Degawa, M. & Yasushi Ohizumi
  Pharmacometrics., in press.
• 36.9-Methyl-7-bromoeudistomin D, a caffeine like Ca2+ releaser, probably
  binds to cytochromes P-450 IA1 and ⅱB in liver microsomes
  Kakubari1, M., Adachi, M., Degawa, M. & Yasushi Ohizumi
  Pharmacometrics., in press.
• 論説・解説
• 1.国民医療費の高騰と医学・薬学の責任
  大泉康日薬理誌, 127, 1-2 (2006)
• 2.応用薬理研究会のこれまでの40年とこれからの40年
  大泉康応用薬理72(1/2), 3 (2007)
• 3.高齢化社会における漢方薬及び機能性食品研究の重要性―アルツハイマー病の対策を中心に―
  大泉康漢方研究7月号, 26-27 (2008)
• 4.高齢化社会における薬用植物の教育研究の重要性について
  大泉康日本薬用植物友の会会報第101号, 2-3 (2008)
• 5.温州ミカン果皮（陳皮）の成分ノビレチンの抗認知症効果―漢方薬及び機能性食品開発をめざして―
  大泉康日本薬用植物友の会会報第103号, 8-11 (2008)
• 6.高齢化社会における漢方薬及び機能性食品研究の重要性―アルツハイマー病の対策を中心に―.
  大泉康漢方研究,7月号, 26-27 (2008).
• 7.高齢化社会における薬用植物の教育研究の重要性について.
  大泉康日本薬用植物友の会会報，第101号, 2-3 (2008).
• 8.温州ミカン果皮（陳皮）の成分ノビレチンの抗認知症効果―漢方薬及び機能性食品開発をめざして―
  大泉康日本薬用植物友の会会報第103号, 8-11 (2008).
• 9.漢方医学、漢方薬を普及させるために何が必要か？
  大泉康漢方研究452, 39-40 (2009)
• 10.アルツハイマー等の認知症の予防・治療法の確立をめざして
  大泉康応用薬理81(1/2)，(2011）印刷中
• 藤原博典
• 11) Fujiwara H., Iwasaki K., Furukawa K., Seki T., Mei H., Maruyama M., Tomita N., Kudo Y., Higuchi M., Saido TC., Maeda S., Takashima A.,
  Hara M., Ohizumi Y., Arai H. (2006) Uncaria rhynchophylla, a Chinese medicinal herb, has potent anti-aggregation effects on Alzheimer’s
  amyloid β proteins. J Neurosci Res. 84 427-433.
• 12) 藤原博典、古川勝敏、荒井啓行(2007) 【認知症への総合的アプローチ】アルツハイマー病の診断と治療戦略アルツハイマー病の薬物
  治療Clinical Neuroscience 25 181-184.
• 13) 藤原博典、岩崎鋼、荒井啓行(2007) 【認知症ケアと医療の地域連携】認知症でも穏やかに暮す漢方治療の新展開Geriatric Medicine
  45 1135-1138
• 14) 藤原博典、古川勝敏、岩崎鋼、関隆志、荒井啓行(2008) 【アルツハイマー病基礎研究から予防・治療の新しいパラダイム】臨床編アルツハイマー病の新しい治療法の開発新規医薬品漢方薬日本臨床66 533-536
• 15) 藤原博典、荒井啓行(2008) 【今日のアルツハイマー病研究王手が掛かった根治薬】Key words 漢方治療カレントテラピー26 362-363
• 16) Hashimoto M., Shahdat MH., Yamashita S., Katakura M., Tanabe Y., Fujiwara H., Gamoh S., Miyazawa T., Arai H., Shimada T., Shido O.
  (2008) DHA disrupts in vitro amyloid β1-40 fibrillation and concomitantly inhibits amyloid levels in cerebral cortex tissue of Alzheimer’s
  disease model rats. J Neurochem. 107 1634-1646.
• 17) Fujiwara H., Tabuchi M., Yamaguchi T., Iwasaki K., Furukawa K., Sekiguchi K., Ikarashi Y., Kudo Y., Higuchi M., Saido TC., Maeda S.,
  Takashima A., Hara M., Nobuo N., Kase Y., Arai H. (2009) A traditional medicinal herb Paeonia suffruticosa and its active constituent
  1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose have potent anti-aggregation effects on Alzheimer’s amyloid β proteins in vitro and in
  vivo. J Neurochem. 109 1648-1657.
• 18) Yamaya M., Nishimura H., Hatachi Y., Yoshida M., Fujiwara H., Asada M., Nakayama K., Yasuda H., Deng X., Sasaki T., Kubo H., Nagatomi
  R. (2011) Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 650 431-444.
• 19) Fujiwara H., Takayama S., Iwasaki K., Tabuchi M., Yamaguchi T., Sekiguchi K., Ikarashi Y., Kudo Y., Kase Y., Arai H., Yaegashi N. (2011)
  Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect
  of cerebral amyloid β proteins in amyloid precursor protein transgenic mice. Neuroscience 180 305–313.
• 110) Fujiwara H., Kogure A., Sakamoto M., Yamakuni T., Mimaki Y., Murata K., Hitomi N., Yamaguchi1K., Ohizumi Y. (2011) Honeybee royal
  jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and dependent fashions, respectively, in PC12D cells. J
  Pharmacol Sci. 116 384-387.