東北大学 珠玖研究室

発表論文


2021

"Thermally-drawn multi-electrode fibers for bipolar electrochemistry and magnified electrochemical imaging"
Tomoki Iwama, Yuanyuan Guo, Shoma Handa, Kumi Y. Inoue, Tatsuo Yoshinobu, Fabien Sorin, Hitoshi Shiku
Advanced Materials Technologies,in press

"Electrochemical Immunoassay with Dual Signal Amplification for Redox Cycling within a Nanoscale Gap"
Kentaro Ito, Kumi Y. Inoue, Takahiro Ito-Sasaki, Kosuke Ino, Hitoshi Shiku
ACS Applied Nano Materials, accepted.

"電気化学反応を使ったハイドロゲルのバイオファブリケーション"
伊野浩介, 宇田川喜信, 梨本裕司, 珠玖 仁
月刊バイオインダストリー,第38巻,第10号,(2021),40-48.

"In vitro electrochemical assays for vascular cells and organs"
Yoshinobu Utagawa, Kaoru Hiramoto, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku
Electrochemical Science Advances, accepted.

"Topography and Permeability Analyses of Vasculature-on-a-Chip Using Scanning Probe Microscopies"
Yuji Nashimoto, Minori Abe, Ryota Fujii, Noriko Taira, Hiroki Ida, Yasufumi Takahashi, Kosuke Ino, Javier Ramon-Azcon, Hitoshi Shiku
Advanced Healthcare Materials, 10, (2021), 2101186.
10.1002/adhm.202101186

"Detection and 2D imaging of dopamine distribution using a closed bipolar electrode system by applying cathodic luminophore"
Tomoki Iwama, Mayo Komatsu, Kumi Y. Inoue, Hitoshi Shiku
ChemElectroChem, 8(18),(2021),3492-3498
10.1002/celc.202100675

"Electrochemical Sensor to Detect Proteinuria Using Peptidases and Glutamate Oxidase Jointly Immobilized on a Prussian Blue-modified Electrode"
Kentaro Ito, Kumi Y. Inoue, Tsubasa Miura, Tomokazu Matsue, Hitoshi Shiku Electrochemistry, 89(5),(2021),409-414
10.5796/electrochemistry.21-00058

"Bipolar-electrode-based electrochromic devices for analytical applications – A review"
Siti Masturah, binti Fakhruddin, Kosuke Ino, Kumi Y. Inoue, Yuji Nashimoto, Hitoshi Shiku
Electroanalysis, accepted.
10.1002/elan.202100153

"Micropipette-based navigation in a microvascular model for imaging endothelial cell topography using scanning ion conductance microscopy"
Noriko Taira, Yuji Nashimoto, Kosuke Ino, Hiroki Ida, Takuto Imaizumi, Akichika Kumatani, YasufumiTakahashi, Hitoshi Shiku
Analytical Chemistry, 93, (2021), 4902–4908.
10.1021/acs.analchem.0c05174

"Electrochemiluminescence imaging of respiratory activity of cellular spheroids using sequential potential steps"
Kaoru Hiramoto, Kosuke Ino, Keika Komatsu, Yuji Nashimoto, Hitoshi Shiku
Biosensors and Bioelectronics, 181, (2021), 113123.
10.1016/j.bios.2021.113123

"Electrodeposition of thiolated polymer-based hydrogels via disulfide formation using electrogenerated benzoquinone"
Kosuke Ino, Ayako Tamura, Kaoru Hiramoto, Mika T. Fukuda, Yuji Nashimoto, Hitoshi Shiku
Chemistry Letters, 50, (2021), 256-259.
10.1246/cl.200732

"多点液滴デバイスを用いるレドックスサイクリングによるメチレンブルーの電気化学計測"
平本薫、小松慶佳、山田祐大、梨本裕司、末永智一、伊野浩介、珠玖仁
分析化学, 70(3), (2021), 183-189.

10.2116/bunsekikagaku.70.183


2020

"Bioimaging using bipolar electrochemical microscopy improved in spatial resolution"
Tomoki Iwama, Kumi Y. Inoue, Hiroya Abe, Tomokazu Matsue and Hitoshi Shiku
Analyst, 145, (2020), 6895-6900.
10.1039/d0an00912a

"Oxygen consumption rate of tumour spheroids during necrotic-like core formation"
Rei Mukomoto, Yuji Nashimoto, Takato Terai, Takuto Imaizumi, Kaoru Hiramoto, Kosuke Ino, Ryuji Yokokawa, Takashi Miura, Hitoshi Shiku
Analyst, 145, (2020), 6342-6348.
10.1039/d0an00979b

"Fabrication of three-dimensional calcium alginate hydrogels using sacrificial templates of sugar"
Kosuke Ino, Mika T. Fukuda, Kaoru Hiramoto, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku
Journal of Bioscience and Bioengineering, 130(5), (2020), 539-544.
10.1016/j.jbiosc.2020.06.014

"Recent Advances in Electrochemiluminescence-Based Systems for Mammalian Cell Analysis"
Kaoru Hiramoto, Elena Villani, Tomoki Iwama, Keika Komatsu, Shinsuke Inagi, Kumi Y. Inoue, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku
Micromachines, 11(5), (2020), 530.
10.3390/mi11050530

"Electrochemical measurement of respiratory activity for evaluation of fibroblast spheroids containing endothelial cell networks"
Kaoru Hiramoto, Hao-jen Pai, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku
Electrochimica Acta, 340, (2020), 135979.
10.1016/j.electacta.2020.135979

"Closed bipolar electrode array for on-chip analysis of cellular respiration by cell aggregates"
Kosuke Ino, Ryosuke Yaegaki, Kaoru Hiramoto, Yuji Nashimoto, Hitoshi Shiku
ACS Sensors, 5(3), (2020), 740-745. Selected as a supplementary cover.
10.1021/acssensors.9b02061

"Biofabrication using electrochemical devices and systems"
Kosuke Ino, Fumisato Ozawa, Ning Dang, Kaoru Hiramoto, Shodai Hino, Rise Akasaka, Yuji Nashimoto, Hitoshi Shiku
Advanced Biosystems, 4, (2020), 1900234.
10.1002/adbi.201900234

"High‐Resolution Electrochemical Mapping of the Hydrogen Evolution Reaction on Transition‐Metal Dichalcogenide Nanosheets"
Yasufumi Takahashi, Yu Kobayashi, Ziqian Wang, Yoshikazu Ito, Masato Ota, Hiroki Ida,Akichika Kumatani, Keisuke Miyazawa, Takeshi Fujita, Hitoshi Shiku, Yuri E. Korchev, Yasumitsu Miyata, Takeshi Fukuma, Mingwei Chen, and Tomokazu Matsue
Angewandte Chemie International Edition, 59, (2020), 3601-3608
10.1002/anie.201912863


2019


"電気化学計測デバイスを用いた細胞の消費物・分泌物評価"
平本薫、伊野浩介、梨本裕司、珠玖仁
Electrochemistry, 87, (2019), 323-328.
10.5796/denkikagaku.19-FE0032

"走査型イオンコンダクタンス顕微鏡による多項目ナノイメージング"
梨本裕司、平典子、伊野浩介、珠玖仁
高分子, 68巻, 12月号, (2019).

"Genipin crosslinking of electrodeposited chitosan/gelatin hydrogels for cell culture"
Ayako Tamura, Kaoru Hiramoto, Kosuke Ino, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku
Chemistry Letters, 48, (2019), 1178–1180.
10.1021/acs.analchem.9b02062

"Site-specific cytosol sampling from a single cell in an intact tumor spheroid using an electrochemical syringe"
Yuji Nashimoto, Masakuni Echigo, Kosuke Ino, Hitoshi Shiku
Analytical Chemistry, 91(14), (2019), 8772-8776. Selected as a cover.
10.1021/acs.analchem.9b02062

"A highly sensitive endotoxin sensor based on redox cycling in a nanocavity"
Kentaro Ito, Kumi Y. Inoue, Kosuke Ino, Tomokazu Matsue, Hitoshi Shiku
Analyst, 144, (2019), 3659-3667.
10.1039/C9AN00478E

"Electric and electrochemical microfluidic devices for cell analysis"
Kaoru Hiramoto, Kosuke Ino, Yuji Nashimoto, Kentaro Ito, Hitoshi Shiku.
Frontiers in Chemistry, 7, (2019), 396.
10.3389/fchem.2019.00396

"第3章 細胞培養に関連した技術研究、第3節 細胞計測技術"
梨本裕司、伊野浩介、平典子、珠玖仁
三次元培養における培養手法と周辺技術動向, 株式会社情報機構、83-97、2019.

"Combination of double-mediator system with large-scale integration-based amperometric devices for detecting NAD(P)H:quinone oxidoreductase 1 activity of cancer cell aggregates"
Kosuke Ino, Takehiro Onodera, Mika T. Fukuda, Yuji Nashimoto, Hitoshi Shiku.
ACS Sensors, 4(6), (2019), 1619-1625. Selected as a supplementary cover.
10.1021/acssensors.9b00344

"ナノポアを用いるエンドトキシンセンサ"
伊藤健太郎、井上(安田)久美、伊藤-佐々木隆弘、末永智一、珠玖仁
分析化学, 68(8), (2019), 575-580.
10.2116/bunsekikagaku.68.575


"Electrodeposition-based rapid bioprinting of 3D-designed hydrogels with a pin art device"
Noriko Taira, Kosuke Ino, Hiroki Ida, Yuji Nashimoto, Hitoshi Shiku.
Biofabrication, 11, (2019), 035018.
10.1088/1758-5090/ab166e

"Electrochemical fabrication of fibrin gels via cascade reaction for cell culture"
Noriko Taira, Kosuke Ino, Tatsuki Kumagai, Yuji Nashimoto, Hitoshi Shiku.
Chemical Communications, 55, (2019), 5335-5338. Selected as a back cover.
10.1039/C9CC01576K

"Electrochemical biosensing system for single cells,cellular aggregates and microenvironments"

Hitoshi Shiku.
Analytical Sciences, 35(1), (2019), 29-38.
10.2116/analsci.18SDR01

"Scanning electrochemical cell microscopy for visualization and local electrochemical activites of lithium-ion (de) intercalation process in lithium-ion batteryies electrodes"
Akichika Kumatani, Yasufumi Takahashi, Chiho Miura, Hiroki Ida, Hirotaka Inomata, Hitoshi Shiku, Hirokazu Munakata, Kiyoshi Kanamura, Tomokazu Matsue.
Surface and Interface Analysis, 51, (2019), 27-30.
10.1002/sia.6538

"Electrochemical imaging of cell activity in hydrogels embedded in grid-shaped polycaprolactone scaffolds using a large-scale integration (LSI)-based amperometric device"
Kosuke Ino, Yuki Yokokawa, Noriko Taira, Atsushi Suda, Ryota Kunikata, Yuji Nashimoto, Tomokazu Matsue, Hitoshi Shiku.
Analytical Sciences, 35(1), (2019), 39-43.
10.2116/analsci.18SDP01

"Differential electrochemicolor imaging using LSI-based device for simultaneous detection of multiple analytes"
Kosuke Ino, Takehiro Onodera, Yuji Nashimoto, Hitoshi Shiku.
Sensors and Materials, 31(1), (2019), 13-22. Selected as a cover.
10.18494/SAM.2019.2035



2018


"電気化学計測に基づく受精卵,胚様体及び細胞塊の機能評価システム"
珠玖 仁
分析化学, 67(11), (2018), 653-660.
10.2116/bunsekikagaku.67.653

"Quantitative real-time monitoring of antibody-induced internalization of epidermal growth factor receptors on single living mammalian cells by scanning electrochemical microscopy"
Yoshiharu Matsumae, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
ChemElectroChem, 5, (2018), 3096-3101.
10.1002/celc.201800563

"Simultaneous multiplex potentiostatic electroanalysis with liquid-junction-removed reference electrode system using a closed bipolar electrode"
Kumi Y. Inoue, Miho Ikegawa, Takahiro Ito-Sasaki, Shinichiro Takano, Hitoshi Shiku, Tomokazu Matsue.
ChemElectroChem, 5, (2018), 2167-2170.
10.1002/celc.201800536

"Simultaneous and selective imaging of dopamine and glutamate using an enzyme-modified large-scale integration (LSI)-based amperometric electrochemical device"
Hiroya Abe, Tomoki Iwama, Hiroshi Yabu, Kosuke Ino, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Tomokazu Matsue.
Electroanalysis, 30, (2018), 2841-2846. Selected as a cover picture.
10.1002/elan.201800386

"Local hydrogel fabrication based on electrodeposition with a large-scale integration (LSI)-based amperometric device"
Kosuke Ino, Mayuko Terauchi, Mai Gakumasawa, Noriko Taira, Atsushi Suda, Ryota Kunikata, Tomokazu Matsue, Hitoshi Shiku.
Sensors and Actuators B: Chemical, 277, (2018), 95-101.
10.1016/j.snb.2018.08.135

"Intracellular electrochemical sensing"
Kosuke Ino, Yuji Nashimoto, Noriko Taira, Javier Ramon Azcon, Hitoshi Shiku.
Electroanalysis, 30, (2018), 2195-2209. Selected as a cover feature.
10.1002/elan.201800410

"Hydrogel electrodeposition based on bipolar electrochemistry"
Kosuke Ino, Tomoaki Matsumoto, Noriko Taira, Tatsuki Kumagai, Yuji Nashimoto, Hitoshi Shiku.
Lab on a Chip, 18, (2018), 2425-2432.
10.1039/C8LC00465J

"Electrochemical printing of calcium alginate/gelatin hydrogel"
Noriko Taira, Kosuke Ino, Jodan Robert, Hitoshi Shiku.
Electrochimica Acta, 281, (2018), 429-436.
10.1016/j.electacta.2018.05.124

"Electrochemicolor imaging of endogenous alkaline phosphatase and respiratory activities of mesenchymal stem cell aggregates in early-stage osteodifferentiation"
Kosuke Ino, Takehiro Onodera, Yusuke Kanno, Atsushi Suda, Ryota Kunikata, Tomokazu Matsue, Hitoshi Shiku.
Electrochimica Acta, 268, (2018), 554-561.
10.1016/j.electacta.2018.02.094

"Micropatterning of Nafion membranes on an electrode array using photolithographic and lift-off techniques for selective electrochemical detection and signal accumulation"
Mayuko Terauchi, Kosuke Ino, Yusuke Kanno, Shunsuke Imai, Hitoshi Shiku, Tomokazu Matsue.
Chemistry Letters, 47(2), (2018), 204-206.
10.1246/cl.171031


2017

"3D electrochemical and ion current imaging using scanning electrochemical–scanning ion conductance microscopy "
Yasufumi Takahashi, Hiroki Ida, Yoshiharu Matsumae, Hirokazu Komaki, Yuanshu Zhou, Akichika Kumatani, Makoto Kanzaki, Hitoshi Shiku, Tomokazu Matsue.
Phys. Chem. Chem. Phys., 19, (2017),26728-26733
10.1039/c7cp05157

"Electrochemicolor imaging using an LSI-Based device for multiplexed cell assays"
Yusuke Kanno, Kosuke Ino, Hiroya Abe, Chika Sakamoto, Takehiro Onodera, Kumi Y Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 89(23), (2017), 12778-12786.
10.1021/acs.analchem.7b03042

"Micro/nanoelectrochemical probe and chip devices for evaluation of three-dimensional cultured cells"
Kosuke Ino, Mustafa Sen, Hitoshi Shiku, Tomokazu Matsue.
Analyst, 142, (2017), 4343-4354.
10.1039/C7AN01442B

"Development of oxygen consumption analysis with an on-chip electrochemical device and simulation"
Kaoru Hiramoto, Masahiro Yasumi, Hiroshi Ushio, Atsushi Shunori, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 89(19), (2017), 10303-10310.
10.1021/acs.analchem.7b02074

"Fabrication of poly(ethylene glycol) hydrogels containing vertically and horizontally aligned graphene using dielectrophoresis: An experimental and modeling study"
Samad Ahadian, Ushio Naito, Velappa Jayaraman Surya, Sorour Darvishi, Mehdi Estili, Xiaobin Liang, Ken Nakajima, Hitoshi Shiku, Yoshiyuki Kawazoe, Tomokazu Matsue.
Carbon, 123, (2017), 460-470.
10.1016/j.carbon.2017.07.082

"Bioelectrochemical applications of microelectrode arrays in cell analysis and engineering"
Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Current Opinion in Electrochemistry, 5, (2017), 146–151.
10.1016/j.coelec.2017.08.004

"Amperometric detection of apoptosis by using p-methoxyaniline-conjugated substrate for caspase-3"
Sun Sixiang, Kumi Y. Inoue, Shusaku Shiomoto, Shinichiro Takano, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
ChemElectroChem, 4, (2017), 941-946.
10.1002/celc.201600700

"超高解像度電気化学顕微鏡の創成と応用"
松岡涼, 青柳重夫, 松本尚志, 松平昌昭, 高橋康史, 熊谷明哉, 井田大貴, 棟方裕一, 飯田克彦, 珠玖仁, 金村聖志, 末永智一
Electrochemistry, 85(6), (2017),319-326.
10.5796/electrochemistry.85.319

"High speed scanning ion conductance microscopy for quantitative analysis of nanoscale dynamics of microvilli"
Hiroki Ida, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 89 (11), (2017), 6015–6020.
10.1021/acs.analchem.7b00584

"An approach to the research on ion and water properties in the interphase between the plasma membrane and bulk extracellular solution"
Hiroshi Hibino, Madoka Takai, Hidenori Noguchi, Seishiro Sawamura, Yasufumi Takahashi, Hideki Sakai, Hitoshi Shiku.
The Journal of Physiological Sciences, 67(4), (2017), 439-445.
10.1007/s12576-017-0530-3

"Scanning probe microscopy for nanoscale electrochemical imaging" Yasufumi Takahashi, Akichika Kumatani, Hitoshi Shiku,Tomokazu Matsue.
Analytical Chemistry, 89(1), (2017), 342-357.
10.1021/acs.analchem.6b04355

"Electrochemical motion tracking of microorganisms using a large-scale-integration-based amperometric device"
Kosuke Ino, Yusuke Kanno, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hitoshi Shiku, Tomokazu Matsue.
Angewandte Chemie International Edition, 56(24), (2017), 6818–6822.
10.1002/anie.201701541

"Binary-number-based digital electrochemical detection using a single working electrode with multiple sensors"
Kosuke Ino, Yusuke Kanno, Yuta Yamada, Hitoshi Shiku, Tomokazu Matsue.
Electrochemistry Communications, 77, (2017), 76-80.
10.1016/j.elecom.2017.02.016

"Continuous collection and simultaneous detection of picoliter volume of nucleic acid samples using a mille-feuille probe"
Hidenori Ito, Motoki Tanaka, Yuanshu Zhou, Yuji Nashimoto, Yasufumi Takahashi, Kosuke Ino, Tomokazu Matsue, Hitoshi Shiku.
Analytical and Bioanalytical Chemistry, 409(4), (2017), 961-969.
10.1007/s00216-016-0006-y

"Cell sheet fabrication using RGD peptide-coupled alginate hydrogels fabricated by an electrodeposition method"
Fumisato Ozawa, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Chemistry Letters, 46(4), (2017), 605-608.
10.1246/cl.170003


2016

"Molecular electrochemical switching element based on diffusive molecular competition for multipoint electrochemical detection of respiration activity of cell aggregates"
Kosuke Ino, Yuta Yamada, Yusuke Kanno, Shunsuke Imai, Hitoshi Shiku,Tomokazu Matsue.
Sensors and Actuators B: Chemical, 234, (2016), 201–208.
10.1016/j.snb.2016.04.160

"Electrochemical imaging for single-cell analysis of cell adhesion using a collagen-coated large-scale integration (LSI)-based amperometric device"
Hiroya Abe, Yusuke Kanno, Kosuke Ino, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hitoshi Shiku, Tomokazu Matsue.
Electrochemistry, 84(5), (2016), 364-367.
10.5796/electrochemistry.84.364

"Redox cycling-based electrochemical reporter gene assay for single cells using a scanning electrochemical microscope-microwell system"
Hiroki Ida, Kosuke Ino, Junya Suzuki, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
Electrochemistry, 84(5), (2016), 308-311.
10.5796/electrochemistry.84.308

"Sequential monitoring of oxygen consumption rate of mouse embryoid bodies in glucose-depleted solution"
Hitoshi Shiku, Nana Aoki, Toshiharu Arai, Yuanshu Zhou, Kumi Y. Inoue, Kosuke Ino, Tomokazu Matsue.
Electrochemistry, 84(5), (2016), 302-304.
10.5796/electrochemistry.84.302

"Electrochemical hydrogel lithography of calcium-alginate hydrogels for cell culture"
Fumisato Ozawa, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Materials, 9(9), (2016), 744.
10.3390/ma9090744

"Evaluation of mRNA localization using double barrel scanning ion conductance microscopy"
Yuji Nashimoto, Yasufumi Takahashi, Yuanshu Zhou, Hidenori Ito, Hiroki Ida, Kosuke Ino, Tomokazu Matsue, Hitoshi Shiku.
ACS Nano, 10 (7), (2016), 6915-6922.
10.1021/acsnano.6b02753

"Potentiometric bioimaging with a large-scale integration (LSI)-based electrochemical device for detection of enzyme activity"
Yusuke Kanno, Kosuke Ino, Chika Sakamoto, Kumi Y. Inoue, Masahki Matsudaira, Atsushi Suda, Ryota Kunikata, Tomohiro Ishikawa, Hiroya Abe, Hitoshi Shiku, Tomokazu Matsue.
Biosensors and Bioelectronics, 77, (2016), 709-714.
10.1016/j.bios.2015.10.021

"Liquid-junction-free system for substitutional stripping voltammetry using a closed bipolar electrode system"
ShinichiroTakano, Kumi Y. Inoue, Miho Ikegawa, Yasufumi Takahashi, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Electrochemistry Communications, 66, (2016), 34-37.
10.1016/j.elecom.2016.02.014

"Hybrid hydrogel-aligned carbon nanotube scaffolds to enhance cardiac differentiation of embryoid bodies"
Samad Ahadian, Shukuyo Yamada, Javier Ramon-Azcon, Mehdi Estili, Xiaobin Liang, Ken Nakajima, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue.
Acta Biomaterialia, 31, (2016), 134-143.
10.1016/j.actbio.2015.11.047

"Graphene induces spontaneous cardiac differentiation in embryoid bodies"
Samad Ahadian, Yuanshu Zhou, Shukuyo Yamada, Mehdi Estili, Xiaobin Liang, Ken Nakajima, Hitoshi Shiku, Tomokazu Matsue.
Nanoscale, 8, (2016), 7075-7084.
10.1039/C5NR07059G

"Localized gene expression analysis during sprouting angiogenesis in mouse embryoid bodies using a double barrel carbon probe"
Hidenori Ito, Yuji Nashimoto, Yuanshu Zhou, Yasufumi Takahashi, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 88, (2016), 610-613.
10.1021/acs.analchem.5b04338

"Developing biomedical nano-grained-type titanium alloys using high pressure torsion for improved cell adherence"
Hakan Yilmazer, Mustafa Sen, Mitsuo Niinomi, Masaaki Nakai, Liu Huihong, Ken Cho, Yoshikazu Todaka, Hitoshi Shikuf, Tomokazu Matsue.
RSC Advances, 9, (2016), 7426-7430.
10.1039/C5RA23454A


2015

"Evaluation of senescence in individual MCF-7 spheroids based on electrochemical measurement of senescence-associated-galactosidase activity"
Yuanshu Zhou, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Electrochimica Acta, 186, (2015), 449-454.
10.1016/j.electacta.2015.10.115

"Local redox cycling-based electrochemical chip device with nanocavities and microwells for multi-electrochemical detection of alkaline phosphatase activity in embryoid bodies from embryonic stem cells"
Yusuke Kanno, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Lab on a Chip, 15, (2015), 4404-4414. Selected as an inside front cover.
10.1039/c5lc01016k

"Hydrogels containing metallic glass sub-micron wires for regulating skeletal muscle cell behavior"
Samad Ahadian, Ramin Banan Sadeghian, Shin Yaginuma, Javier Ramon-Azcon, Yuji Nashimoto, Xiaobin Liang, Hojae Bae, Ken Nakajima, Hitoshi Shiku, Tomokazu Matsue, Koji S. Nakayama, Ali Khademhosseini.
Biomaterials Science, 3(11), (2015), 1449-1458.
10.1039/c5bm00215j

"局所レドックスサイクルを用いた電気化学バイオイメージングシステムの開発"
伊野浩介、珠玖 仁、末永智一.
分析化学, 64(9), (2015), 669-678
10.2116/bunsekikagaku.64.669

"Metabolic suppression during mesodermal differentiation of embryonic stem cells identified by single-cell comprehensive gene expression analysis"
Yuanshu Zhou, Ikuma Fujisawa, Kosuke Ino, Tomokazu Matsue, Hitoshi Shiku.
Molecular BioSystems, (11), (2015), 2560-2567.
10.1039/C5MB00340G

"Simulation analysis of positional relationship between embryoid bodies and sensors on an LSI-based amperometric device for electrochemical imaging of alkaline phosphatase activity"
Yusuke Kanno, Kosuke Ino, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hitoshi Shiku, Tomokazu Matsue.
Analytical Sciences, 31(7), (2015), 715-719.
10.2116/analsci.31.715

"Electrochemical imaging of dopamine release from three- dimensional-cultured PC12 cells using large-scale integration- based amperometric sensors"
Hiroya Abe, Kosuke Ino, Chen-Zhong Li, Yusuke Kanno, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 87(12), (2015), 6364-6370.
10.1021/acs.analchem.5b01307

"Facile and green production of aqueous graphene dispersions for biomedical applications"
Samad Ahadian, Mehdi Estili, Velappa Jayaraman Surya, Javier Ramon-Azcon, Xiaobin Liang, Hitoshi Shiku, Murugan Ramalingam, Tomokazu Matsue, Yoshio Sakka, Hojae Bae, Ken Nakajima, Yoshiyuki Kawazoe, Ali Khademhosseini.
Nanoscale, 7(15), (2015), 6436-6443.
10.1039/c4nr07569b

"Improving the electrochemical imaging sensitivity of scanning electrochemical microscopy-scanning ion conductance microscopy by using electrochemical Pt deposition"
Mustafa Sen, Yasufumi Takahashi, Yoshiharu Matsumae, Yoshiko Horiguchi, Akichika Kumatani, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 87(6), (2015), 3484-3489.
10.1021/acs.analchem.5b00027

"Mechanical properties and cytocompatibility of oxygen-modified beta-type Ti-Cr alloys for spinal fixation devices"
Huihong Liu, Mitsuo Niinomi, Masaaki Nakai, Ken Cho, Kengo Narita, Mustafa Sen, Hitoshi Shiku, Tomokazu Matsue.
Acta Biomaterialia, 12, (2015), 352-361.
10.1016/j.actbio.2014.10.014

"Advanced LSI-based amperometric sensor array with light-shielding structure for effective removal of photocurrent and mode selectable function for individual operation of 400 electrodes"
Kumi Y. Inoue, Masahki Matsudaira, Masanori Nakano, Kosuke Ino, Chika Sakamoto, Yusuke Kanno, Reyushi Kubo, Ryota Kunikata, Atsushi Kira, Atsushi Suda, Ryota Tsurumi, Toshihito Shioya, Shinya Yoshida, Masanori Muroyama, Tomohiro Ishikawa, Hitoshi Shiku, Shiro Satoh, Masayoshi Esashi, Tomokazu Matsue.
Lab on a Chip, 15, (2015), 848-856.
10.1039/C4LC01099J

"Feedback mode-based electrochemical imaging of conductivity and topography for large substrate surfaces using an LSI-based amperometric chip device with 400 sensors"
Yusuke Kanno, Kosuke Ino, Kumi Y. Inoue, Mustafa Sen, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hiroya Abe, Chen-Zhong Li, Hitoshi Shiku, Tomokazu Matsue.
Journal of Electroanalytical Chemistry, 741, (2015), 109-113.
10.1016/j.jelechem.2015.01.020

"Nanoscale imaging of an unlabeled secretory protein in living cells using scanning ion conductance microscopy"
Yuji Nashimoto, Yasufumi Takahashi, Hiroki Ida, Yoshiharu Matsumae, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 87(5), (2015), 2542-2545.
10.1021/ac5046388


2014

"Three-dimensional co-culture of C2C12/PC12 cells improves skeletal muscle tissue formation and function"
Serge Ostrovidov, Samad Ahadian, Javier Ramon-Azcon, Vahid Hosseini, Toshinori Fujie, S.Prakash Parthiban, Hitoshi Shiku, Tomokazu Matsue, Hirokazu Kaji, Murugan Ramalingam, Hojae Bae, Ali Khademhosseini.
Journal of Tissue Engineering and Regenerative Medicine, 11(2), (2014), 582–595.
10.1002/term.1956

"Nanoscale visualization of redox activity at Lithium ion battery cathodes"
Yasufumi Takahashi, Akichika Kumatani, Hirokazu Munakata, Hirotaka Inomata, Komachi Ito, Kosuke Ino, Hitoshi Shiku, Patrick R. Unwin, Yuri E. Korchev, Kiyoshi Kanamura, Tomokazu Matsue.
Nature Communications, 5, (2014), 5450.
10.1038/ncomms6450

"Electrochemical monitoring of intracellular enzyme activity of single living mammalian cells by using a double-mediator system"
Yoshiharu Matsumae, Yasufumi Takahashi, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Analytica Chimica Acta, 842, (2014), 20-26.
10.1016/j.aca.2014.06.047

"Electrochemical sensor with substitutional stripping voltammetry for highly sensitive endotoxin assay"
Shinichiro Takano, Kumi Y. Inoue, Satoko Takahashi, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Analyst, 139, (2014), 5001-5006.
10.1039/c4an00510d

"Rapid and high-throughput formation of 3D embryonic bodies in hydrogels using dielectrophoresis technique"
Samad Ahadian, Shukuyo Yamada, Javier Ramon-Azcon, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue.
Lab on a Chip, 14, (2014), 3690-3694.
10.1039/c4lc00479e

"Electrochemical evaluation of sarcomeric α-actinin in embryoid bodies after gene silencing using an LSI-based amperometric sensor array"
Mustafa Sen, Kosuke Ino, Kumi Y. Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Hitoshi Shiku, Tomokazu Matsue.
Analytical Methods, 6, (2014), 6337-6342.
10.1039/c4ay00791c

"Facile and rapid generation of 3D chemical gradients within hydrogels for high-throughput drug screening applications"
Samad Ahadian, Javier Ramon-Azcon, Mehdi Estili, Raquel Obregon, Hitoshi Shiku, Tomokazu Matsue.
Biosensors and Bioelectronics, 59, (2014), 166-173.
10.1016/j.bios.2014.03.031

"Electrochemical approach for development of a simple method to detect the cell apoptosis based on caspase-3 activity"
Shinichiro Takano, Shusaku Shiomoto, Kumi Y. Inoue, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 86(10), (2014), 4723-4728.
10.1021/ac403394z

"Hybrid hydrogels containing vertically aligned carbon nanotubes with anisotropic electrical conductivity for muscle myofiber fabrication"
Samad Ahadian, Javier Ramon-Azcon, Mehdi Estili, Xiaobin Liang, Serge Ostrovidov, Hitoshi Shiku, Murugan Ramalingam, Ken Nakajima, Yoshio Sakka, Hojae Bae, Tomokazu Matsue, Ali Khademhosseini.
Scientific Reports, 4, (2014), 4271.
10.1038/srep04271

"Nanoscale cell surface topography imaging using scanning ion conductance microscopy"
Yasufumi Takahashi, Komachi Ito, Xiongwei Wang, Yoshiharu Matsumae, Hirokazu Komaki, Akichika Kumatani, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Electrochemistry, 82(5), (2014), 331-334.
10.5796/electrochemistry.82.331

"Electrically regulated differentiation of skeletal muscle cells on ultrathin graphene-based films"
Samad Ahadian, Javier Ramon-Azcon, Haixin Chang, Xiaobin Liang, Hirokazu Kaji, Hitoshi Shiku, Ken Nakajima, Murugan Ramalingam, Hongkai Wu, Tomokazu Matsue, Ali Khademhosseini.
RSC Advances, 4(19), (2014), 9534-9541.
10.1039/c3ra46218h

"Densified electrochemical sensors based on local redox cycling between vertically separated electrodes in substrate generation/chip collection and extended feedback modes"
Kosuke Ino, Yusuke Kanno, Taku Nishijo, Hirokazu Komaki, Yuta Yamada, Sinya Yoshida, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 86(8), (2014), 4016-4023.
10.1021/ac500435d

"Noninvasively measuring respiratory activity of rat primary hepatocyte spheroids by scanning electrochemical microscopy"
Ryosuke Takahashi, Yuanshu Zhou, Yoshiko Horiguchi, Hitoshi Shiku, Hiroshi Sonoda, Naoshi Itabashi, Jiro Yamamoto, Taku Saito, Tomokazu Matsue, Akiko Hisada.
Journal of Bioscience and Bioengineering, 17(1), (2014), 113-121.
10.1016/j.jbiosc.2013.06.021

"Isolation and quantification of messenger RNA from tissue models by using a double-barrel carbon probe"
Yuji Nashimoto, Yasufumi Takahashi, Ryosuke Takano, Kosuke Miyashita, Shukuyo Yamada, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Analytical and Bioanalytical Chemistry, 406(1), (2014), 275-282.
10.1007/s00216-013-7430-z

"Detection of the oxygen consumption rate of migrating zebrafish by electrochemical equalization systems"
Tomoyuki Yasukawa, Masahiro Koide, Norihisa Tatarazako, Ryoko Abe, Hitoshi Shiku, Fumio Mizutani, Tomokazu Matsue.
Analytical Chemistry, 86(1), (2014), 304-307.
10.1021/ac402962f

"SU-8-based flexible amperometric device with IDA electrodes to regenerate redox species in small spaces"
Yusuke Kanno, Takehito Goto, Kosuke Ino, Kumi Y. Inoue, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
Analytical Sciences, 30(2), (2014), 305-309.
10.2116/analsci.30.305

"Molecular motor-powered shuttles along multiwalled carbon nanotube tracks"
Aurelien Sikora, Javier Ramon-Azcon, Kyongwan Kim, Kelley Reaves, Hikaru Nakazawa, Mitsuo Umetsu, Izumi Kumagai, Tadafumi Adschiri, Hitoshi Shiku, Tomokazu Matsue, Wonmuk Hwang, Winfried Teizer.
Nano Letters, 14(2), (2014), 876-881.
10.1021/nl4042388

"Droplet array on local redox cycling-based electrochemical (LRC-EC) chip device"
Kosuke Ino, Takehito Goto, Yusuke Kanno, Kumi Y. Inoue, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
Lab on a Chip, 14(4), (2014), 787-794.
10.1039/C3LC51156A

"The use of microtechnology and nanotechnology in fabricating vascularized tissues"
Raquel Obregon, Javier Ramon-Azcon, Samad Ahadian, Hitoshi Shiku, Hojae Bae, Murugan Ramalingam, Tomokazu Matsue.
Journal of Nanoscience and Nanotechnology, 14(1), (2014), 487-500.
10.1166/jnn.2014.9051

"東北大学のMEMS拠点-異分野融合と協働から生まれたバイオLSI"
井上(安田)久美、伊野浩介、珠玖 仁、末永智一.
Electrochemistry, 82(1), (2014), 37-42
10.5796/electrochemistry.82.37


2013

"Noninvasive measurement of respiratory activity of mouse embryoid bodies and its correlation with mRNA levels of undifferentiation/differentiation markers"
Hitoshi Shiku, Toshiharu Arai, Yuanshu Zhou, Nana Aoki, Taku Nishijo, Yoshiko Horiguchi, Kosuke Ino, Tomokazu Matsue.
Molecular BioSystems, 9, (2013), 2701-2711.
10.1039/C3MB70223E

"Noninvasive measurement of alkaline phosphatase activity in embryoid bodies and coculture spheroids with scanning electrochemical microscopy"
Toshiharu Arai, Taku Nishijo, Yoshiharu Matsumae, Yuanshu Zhou, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 85 (20) 9647-9645, (2013), 9647-9654.
10.1021/ac401824q

"Positioning of cells in a fluidic channel by negative dielectrophoresis"
Tomoyuki Yasukawa, Junko Yamada, Hitoshi Shiku, Fumio Mizutani, Tomokazu Matsue.
Sensors and Actuators B: Chemical,186, (2013), 9-16.
10.1016/j.snb2013.05.048

"Screen-printed endotoxin sensor based on amperometry using novel p-aminophenol conjugated substrate for Limulus amebocyte lysate protease reaction"
Kumi Y. Inoue, Shinichiro Takano, Satoko Takahashi, Yosuke Ishida, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Analyst, 138, (2013), 6523-6531.
10.1039/C3AN01202F

"Cell pairing using dielectrophoresis-based device with IDA electrodes"
Mustafa Sen, Kosuke Ino, Javier Ramon-Azcon, Hitoshi Shiku, Tomokazu Matsue.
Lab on a Chip, 13(18), (2013), 3650-3652.
10.1039/C3LC50561H

"Electrochemical device with interdigitated ring array electrodes for investigating the relationship between cardiomyocyte differentiation from embryonic stem cells and alkaline phosphatase activity"
Kosuke Ino, Taku Nishijo, Yusuke Kanno, Fumisato Ozawa, Toshiharu Arai, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
Electrochemistry, 81, (2013), 682-687.
10.5796/electrochemistry.81.682

"Non-invasive measurement of glucose uptake of skeletal muscle tissue models using a glucose nanobiosensor"
Raquel Obregon, Samad. Ahadian, Javier Ramon-Azcon, Luyang Chen, Serge Ostrovidov, Gulden Camci-Unal, Takeshi Fujita, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Mingwei Chen, Tomokazu Matsue.
Biosensors and Bioelectronics, 50, (2013), 194-201.
10.1016/j.bios.2013.06.020

"Dielectrophoretically aligned carbon nanotubes to control electrical and mechanical properties of hydrogels to fabricate contractile muscle myofibers"
Javier Ramon-Azcon, Samad Ahadian, Mehdi Estili, Xiaobin Liang, Serge Ostrovidov, Hirokazu Kaji, Hitoshi Shiku, Yoshio Sakka, Ken Nakajima, Murugan Ramalingam, Ali Khademhosseini, Tomokazu Matsue.
Advanced Materials, 25(29), (2013), 4028-4034.
10.1002/adma.201301300

"Multi-parameter analyses of three dimensionally cultured tumor spheroids based on respiration activity and comprehensive gene expression profiles"
Yuanshu Zhou, Toshiharu Arai, Yoshiko Horiguchi, Kosuke Ino, Tomokazu Matsue, Hitoshi Shiku.
Analytical Biochemistry, 439, (2013), 187-193.
10.1016/j.ab.2013.04.020

"Carbon-Ag/AgCl probes for detection of cell activity in droplets"
Kosuke Ino, Kaoru Ono, Toshiharu Arai, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 85(8), (2013), 3832-3835.
10.1021/ac303569t

"LSI-based amperometric sensor for real-time monitoring of embryoid bodies"
Mustafa Sen, Kosuke Ino, Kumi Y.Inoue, Toshiharu Arai, Taku Nishijo, Atsushi Suda, Ryota Kunikata, Hitoshi Shiku, Tomokazu Matsue.
Biosensors and Bioelectronics, 48, (2013), 12-18.
10.1016/j.bios.2013.03.069

"Tacrolimus inhibits the revascularization of isolated pancreatic islets"
Ryuichi Nishimura, Sho Nishioka, Ikuma Fujisawa, Hitoshi Shiku, Miki Shimada, Satoshi Sekiguchi, Keisei Fujimori, Akira Ushiyama, Tomokazu Matsue, Noriaki Ohuchi, Susumu Satomi, Masafumi Goto.
PLoS One, 8(4), (2013), e56799.
10.1371/journal.pone.0056799

"Alginate gel microwell arrays using electrodeposition for three-dimensional cell culture"
Fumisato Ozawa, Kosuke Ino, Toshiharu Arai, Javier Ramon-Azcon, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
Lab on a Chip, 13(15), (2013), 3128-3135.
10.1039/C3LC50455G

"Evaluation of the differentiation status of single embryonic stem cells by using scanning electrochemical microscopy"
Yoshiharu Matsumae, Toshiharu Arai, Yasufumi Takahashi, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Chemical Communications, 49(58), (2013), 6498-6500.
10.1039/C3CC43126F

"A contactless electrical stimulator: Application to fabricate functional skeletal muscle tissue"
Samad Ahadian, Javier Ramon-Azcon, Serge Ostrovidov, Gulden Camci-Unal, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue.
Biomedical Microdevices, 15(1), (2013), 109-115.
10.1007/s10544-012-9692-1

"Electrodeposition of alginate gels for construction of vascular-like structures"
Fumisato Ozawa, Kosuke Ino, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
Journal of Bioscience and Bioengineering, 115(4), (2013), 459-461.
10.1016/j.jbiosc.2012.10.014


2012

"Interdigitated array of Pt electrodes for electrical stimulation and engineering of aligned muscle tissue"
Samad Ahadian, Javier Ramon-Azcon, Serge Ostrovidov, Gulden Camci-Unal, Vahid Hosseini, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue.
Lab on a Chip, 12, (2012), 3491-3503.
10.1039/C2LC40479F

"LSI-based amperometric sensor for bio-imaging and multi-point biosensing"
Kumi Y. Inoue, Masahki Matsudaira, Reyushi Kubo, Masanori Nakano, Shinya Yoshida, Sakae Matsuzaki, Atsushi Suda, Ryota Kunikata, Tatsuo Kimura, Ryota Tsurumi, Toshihito Shioya, Kosuke Ino, Hitoshi Shiku, Shiro Sato, Masayoshi Esashi and Tomokazu Matsue.
Lab on a Chip, 12, (2012), 3481-3490.
10.1039/C2LC40323D

"Electrochemical detection for dynamic analyses of a redox component in droplets using a local redox cycling-based electrochemical (LRC-EC) chip device"
Kosuke Ino, Yusuke Kanno, Taku Nishijo, Takehito Goto, Toshiharu Arai, Yasufumi Takahashi, Hitoshi Shiku and Tomokazu Matsuea.
Chemical Communications, 48, (2012), 8505-8507.
10.1039/c2cc34264b

"Accumulation and detection of secreted proteins from single cells for reporter gene assays using a local redox cycling-based electrochemical (LRC-EC) chip device"
Mustafa Sen, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Lab on a Chip, 12, (2012), 4328-4335.
10.1039/c2lc40674h

"A novel electrochemical methodology for activity estimation of alkaline phosphatase based on solubility difference"
Kosuke Ino, Yusuke Kanno, Toshiharu Arai, Kumi Y Inoue, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 84, (2012), 7593-7598.
10.1021/ac301429n

"細胞内での分子反応を計測する―受精卵、細胞塊、組織の1細胞分析技術"
珠玖 仁, 末永智一.
バイオマテリアル‐生体材料‐, 30(3), (2012), 153-158

"Development of an electrochemical Limulus amebocyte lysate assay technique for portable and highly sensitive endotoxin sensor"
Kumi Y. Inoue, Satoko Takahashi, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Innate Immunity, 18, (2012), 343-349.
10.1177/1753425911410337

"Gelatin methacrylate as a promising hydrogel to establish 3D microscale organization and proliferation of dielectrophoretic patterned cells"
Javier Ramon-Azcon, Samad Ahadian, Raquel Obregon, Gulden Camci-Unal, Serge Ostrovidov, Vahid Hosseini, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue.
Lab on a Chip,12, (2012), 2959-2969.
10.1039/C2LC40213K

"A facile method for patterned growth of ZnO nanowires using a black ink"
Sang Hyun Lee, Hyun Jung Lee, Hitoshi Shiku, Takafumi Yao, Tomokazu Matsue.
Electronic Materials Letters, 8, (2012), 511-518.
10.1007/s13391-012-2047-5

"Local redox cycling-based electrochemical chip device with deep microwells for evaluation of embryoid bodies"
Kosuke Ino, Taku Nishijo, Toshiharu Arai, Yusuke Kanno, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsue.
Angewandte Chemie International Edition, 51(27), (2012), 6648-6652.
10.1002/anie.201201602

"Topographical and electrochemical nanoscale imaging of living cells using voltage-switching mode scanning electrochemical microscopy"
Yasufumi Takahashi, Andrew I. Shevchuk, Pavel Novak, Babak Babakinejad, Julie V. Macpherson, Patrick R. Unwin, Hitoshi Shiku, Julia Geolick, David Klenerman, and Yuri E. Korchev, Tomokazu Matsue.
Proceedings of the National Academy of Sciences of the United States of America, 109(29), (2012), 11540-11545.
10.1073/pnas.1203570109

"Patterning with particles using three-dimensional interdigitated array electrodes with negative dielectrophoresis and its application to simple immunosensing"
Masashi Yamamoto, Tomoyuki Yasukawa, Masato Suzuki, Satoshi Kosuge, Hitoshi Shiku, Tomokazu Matsue, Fumio Mizutani.
Electrochimica Acta, 85, (2012), 35-42.
10.1016/j.electacta.2012.02.109

"A Pt layer/ Pt disk microelectrode configuration to evaluate respiration and alkaline phosphatase activities of mouse embryoid bodies"
Raquel Obregon, Yoshiko Horiguchi, Toshiharu Arai, Shihomi Abe, Yuanshu Zhou, Ryosuke Takahashi, Akiko Hisada, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Talanta, 94, (2012), 30-35.
10.1016/j.talanta.2012.01.059

"Microfluidic heavy metal immunoassay based on absorbance measurement"
Yasumoto Date, Shingo Terakado, Kazuhiro Sasaki, Arata Aota, Norio Matsumoto, Hitoshi Shiku, Kosuke Ino, Yoshitomo Watanabe, Tomokazu Matsue, Naoya Ohmura.
Biosensors and Bioelectronics, 33(1), (2012), 106-112.
10.1016/j.bios.2011.12.030.

"A new electrochemical assay method for gene expression using HeLa cells with a secreted alkaline phosphatase (SEAP) reporter system"
Mustafa Sen, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Biotechnology and Bioengineering, 109(8), (2012), 2163-2167.
10.1002/bit.24461

"「使える解析テクニック!」シリーズ、マイクロ電極(3)応用計測事例:電気化学顕微鏡(SECM)- 走査型イオンコンダクタンス顕微鏡(SICM)複合システムの開発"
高橋康史、珠玖 仁、末永智一
Electrochemistry,80, (2012), 271-275.
10.5796/electrochemistry.80.271

"Microfluidic devices for electrochemical measurement of photosynthetic activity of cyanobacteria microcystis cells"
Masahiro Koide, Tomoyuki Yasukawa, Yoshiko Horiguchi, Kuniaki Nagamine, Hitoshi Shiku, Tomokazu Matsue, Tomoaki Itayama.
Analytical Sciences, 28, (2012), 69-72.
10.2116/analsci.28.69

"Improvement of detectable sensitivity for enzyme reaction by scanning electrochemical microscopy with distance control system for immunosensing"
Yu Hirano, Tomoyuki Yasukawa, Yoshiaki Mase, Daisuke Oyamatsu, Hitoshi Shiku, Fumio Mizutani, Tomokazu Matsue.
Electrochemistry, 80, (2012), 30-32.
10.5796/electrochemistry.80.30


2011

"電気化学ナノイメージング、in監修 民谷栄一"
珠玖 仁、末永智一
“ナノ融合による先進バイオデバイス”第4章3節PP. 156-162. (2011) ,シーエムシー出版,
東京 2011年11月30日発行

"Electrochemical detection of receptor-mediated endocytosis by scanning electrochemical microscopy"
Yasufumi Takahashi, Takeshi Miyamoto, Hitoshi Shiku, Kosuke Ino, Tomoyuki Yasukawa, Ryutaro Asano, Izumi Kumagai, Tomokazu Matsue.
Physical Chemistry Chemical Physics, 13, (2011), 16569-16573.
10.1039/c1cp21886g

"Multifunctional nanoprobes for nanoscale chemical imaging and localized chemical delivery at surfaces and interfaces"
Yasufumi Takahashi, Andrew I. Shevchuk, Pavel Novak, Yanjun Zhang, Neil Ebejer, Julie V. Macpherson, Patrick R. Unwin, Andrew Pollard, Debdulal Roy, Charles A. Clifford, Hitoshi Shiku, Tomokazu Matsue, David Klenerman, Yuri E. Korchev.
Angewandte Chemie International Edition, 50(41), (2011), 9638-9642.
10.1002/anie.201102796

"Monitoring oxygen consumption of single mouse embryos using an integrated electrochemical microdevice"
Yasumoto Date, Shinichiro Takano, Hitoshi Shiku, Kosuke Ino, Takahiro Ito-Sasaki, Masaki Yokoo, Hiroyuki Abe, Tomokazu Matsue.
Biosensors and Bioelectronics
, 30, (2011), 100-106.
10.1016/j.bios.2011.08.037

"Amperometric detection of DNA Hybridization using a multi-point, addressable electrochemical device"
Xi Zhu, Kosuke Ino, Zhenyu Lin, Hitoshi Shiku, Guonan Chen, Tomokazu Matsue.
Sensors and Actuators B: Chemical, 160(1), (2011), 923-928.
10.1016/j.snb.2011.09.004

"Electrochemical chip integrating scalable ring-ring electrode array to detect secreted alkaline phosphatase"
Michiaki Takeda, Hitoshi Shiku, Kosuke Ino, Tomokazu Matsue.
Analyst, 136(23), (2011), 4991-4996.
10.1039/C1AN15620A

"An electrochemical device with microwells for determining the photosynthetic activity of a single cyanobacterium"
Masahiro Koide, Tomoyuki Yasukawa, Kuniaki Nagamine, Hitoshi Shiku, Tomoaki Itayama, Tomokazu Matsue.
Sensors and Actuators B: Chemical, 153, (2011), 474-478.
10.1016/j.snb.2010.10.051

"Electrorotation chip consisting of three-dimensional interdigitated array electrodes"
Kosuke Ino, Atsuko Ishida, Kumi Y. Inoue, Masato Suzuki, Masahiro Koide, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
Sensors and Actuators B: Chemical,153, (2011), 468-473.
10.1016/j.snb.2010.11.012

"Addressable electrode array device with IDA electrodes for high-throughput detection" Kosuke Ino, Wataru Saito, Masahiro Koide, Taizo Umemura, Hitoshi Shiku, Tomokazu Matsue.
Lab on a Chip,11, (2011), 385-388.
10.1039/c0lc00437e

"Influence of tip size on single yeast cell imaging with scanning electrochemical microscopy"
Kuniaki Nagamine, Yasufumi Takahashi, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Electroanalysis, 23, (2011), 1168-1174. .
10.1002/elan.201000595


2010

"Fabrication of line and grid patterns with cells based on negative dielectrophoresis"
Tomoyuki Yasukawa*, Masato Suzuki, Hitoshi Shiku, Tomokazu Matsue.
Journal of Robotics and Mechatronics, 22(5), (2010), 613-618.
10.20965/jrm.2010.p0613

"Chronoamperometric characterization of secreted alkaline phosphatase from single cell entrapped in a poly(dimethylsiloxisane) microwell"
Hitoshi Shiku, Junya Suzuki, Tatsuya Murata, Kosuke Ino, Tomokazu Matsue.
Electrochimica Acta, 55, (2010), 8623-8627.
10.1016/j.electacta.2010.04.011

"単一細胞由来mRNAの定量解析"
珠玖 仁、伊野浩介、末永智一
Electrochemistry, 78(10), (2010), 832-836.

"流路培養による微小環境の再現"
珠玖 仁
生物工学
88(10), (2010), 533

"呼吸活性を指標とした胚の品質評価―マウス胚移植試験の成績と産子の正常性について"
横尾正樹、伊藤-佐々木隆広、珠玖 仁、末永智一、阿部宏之
産婦人科の実際, 59(9), (2010), 1375-1379

"Reporter gene expression at single-cell level characterized with real-time RT-PCR, chemluminescence, fluorescence, and electrochemical imaging"
Hitoshi Shiku, Daisuke Okazaki, Junya Suzuki, Yasufumi Takahashi, Tatsuya Murata, Hidetaka Akita, Hideyoshi Harashima, Kosuke Ino, Tomokazu Matsue.
FEBS Lett., 584, (2010), 4000-4008.
10.1016/j.febslet.2010.08.008

"Simultaneous noncontact topography and electrochemical imaging by SECM/SICM featuring ion current feedback regulation"
Yasufumi Takahashi, Andrew I. Shevchuk, Pavel Novak, Yumi Murakami, Hitoshi Shiku, Yuri E. Korchev, Tomokazu Matsue.
Journal of the American Chemical Society, 132(29), (2010), 10118-10126.
10.1021/ja1029478

"Electrochemical detection of endotoxin using recombinant factor C zymogen"
Kumi Y. Inoue. Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Electrochemistry Communications, 12, (2010), 1066-1069.
10.1016/j.elecom.2010.05.028

"Topographic imaging of convoluted surface of live cells by scanning ion conductance microscopy in a standing approach mode"
Yasufumi Takahashi, Yumi Murakami, Kuniaki Nagamine, Hitoshi Shiku, Shigeo Aoyagi, Tomoyuki Yasukawa, Makoto Kanzaki, Tomokazu Matsue.
Physical Chemistry Chemical Physics, 12, (2010), 10012-10017. .
10.1039/C002607G

"酵素利用技術体系-基礎・解析から改変・高機能化・産業利用まで"
末永智一,高橋康史,伊野浩介,珠玖 仁
走査型電気化学顕微鏡による酵素イメージングp. 112-116(第2編、第2節).
株式会社エヌ・ティー・エス, (2010)

“シングルセル解析の最前線”
珠玖 仁、伊野浩介、末永智一
単一細胞由来mRNA回収プローブの開発
 (第4章3節PP. 223-228 (9ページ).
株式会社シーエムシー出版, (2010)

"Electrochemical characterization of enzyme and immunoglobulin G patterned using microcontact printing"
Hitoshi Shiku, Ayako Kumagai, Hong Q. Luo, Yasufumi Takahashi, Tomoyuki Yasukawa, Hiroshi Yamada, Tomokazu Matsue.
Electrochemistry, 78, (2010), 122-125.
10.5796/electrochemistry.78.122

"Preparation of immunosensors using a microfluidic device with an interdegitated array electrode modified with antibodies"
Yu Hirano, Tomoyuki Yasukawa, Yoshihiro Sawayashiki, Hitoshi Shiku, Fumio Mizutani, Tomokazu Matsue.
Electrochemistry, 78, (2010), 175-177.
10.5796/electrochemistry.78.175

"Addressable electrochemiluminescence detection system based on redox-cycling of Ru(bpy)32+"
Zhenyu Lin, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue, Guonan Chen.
Chemical Communications, 46, (2010), 243-245.
10.1039/b915871e

"Electrochemical topography of a cell monolayer with an addressable microelectrode array"
Z. Lin, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Chemical Communications, 46, (2010), 559-561.
10.1039/B915212A


2009

"Electrochemical monitoring of hydrogen peroxide released from leucocytes on horseradish peroxidase redox polymer coated electrode chip"
Kumi Y. Inoue. Kosuke Ino, Hitoshi Shiku, Shigenobu Kasai, Tomoyuki Yasukawa, Fumio Mizuntani, Tomokazu Matsue.
Biosens. Bioelectron., 25, (2010), 1723-1728. .
10.1016/j.bios.2009.12.014

"Rapid and simple immunosensing system for simultaneous detection of tumor markers based on negative-dielectrophoretic manipulation of microparticles"
Hyun Jung Lee, Sang Hyun Lee, Tomoyuki Yasukawa, Javier Ramon-Azcon, Fumio Mizutani, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue.
Talanta, 81, (2010), 657-663.
10.1016/j.talanta.2009.12.058

"Transfected single cell imaging by scanning electrochemical optical microscopy with shear force feedback regulation"
Yasufumi Takahashi, Hitoshi Shiku, Tatsuya Murata, Tomoyuki Yasukawa, Tomokazu Matsue.
Anal. Chem., 81(23), (2009), 9674-9681.
10.1021/ac901796r

"Microfluid-assisted dielectrophoretic alignment and device characterization of single ZnO wires"
Sang Hyun Lee, Hyun Jung Lee, Kosuke Ino, Hitoshi Shiku, Takafumi Yao, Tomokazu Matsue.
J. Phys. Chem. C, 113, (2009), 19376-19381.
10.1021/jp908161v

"Control of the microparticle position in the channel based on dielectrophoresis"
Tomoyuki Yasukawa, Masato Suzuki, Hitoshi Shiku, Tomokazu Matsue
Sens. Actuat. B, 142, (2009), 400-403.
10.1016/j.snb.2009.07.024

"Detection of hormone active chemicals using genetically-engineered yeast cells and microfludic devices with interdigitated array electrodes"
Kosuke Ino, Yusuke Kitagawa, Tsuyoshi Watanabe, Hitoshi Shiku, Masahiro Koide, Tomoaki Itayama, Tomoyuki Yasukawa, Tomokazu Matsue
Electrophoresis, 30(19), (2009), 3406-341.
10.1002/elps.200900244

"Manipulation of microparticles for construction of array patterns by negative dielectrophoresis using multilayered array and grid electrodes"
Kosuke Ino, Hitoshi Shiku, Fumisato Ozawa, Tomoyuki Yasukawa, Tomokazu Matsue.
Biotechnol. Bioeng., 104, (2009), 709-718.
10.1002/bit.22445

"Electrochemical single-cell gene expression assay combining dielectrophoretic manipulation with secreted alkaline phosphatase reporter system"
Tatsuya Murata, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
Biosens. Bioelectron., 25, (2009), 913-919.
10.1016/j.bios.2009.09.001

"Lateral arrays of vertical ZnO nanowalls on a periodically polarity-inverted ZnO template"
Sang HyunLee, Tsutomu Minegishi, Jun-Seok Ha, Jin-sub Park, Hyo-JongLee, Hyun Jung Lee, Hitoshi Shiku, Tomokazu Matsue, Hong, Heonsu Jeon.
Nanotechnology, 20, (2009), 235304.
10.1088/0957-4484/20/23/235304

"Three dimensional microelectrode array device integrating multi-channel microfluidics to realize manipulation and characterization of enzyme-immobilized polystyrenebeads"
Ryouta Kunikata, Yasufumi Takahashi, Masahiro Koide, Tomoaki Itayama, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
Sens Actuat B, 141, (2009), 256-262.
10.1016/j.snb.2009.05.028

"電気化学的多点計測デバイス"
珠玖 仁、伊野浩介、末永智一
未来材料, 9(8), (2009), 56-61

"Development of electrochemical reporter assay using HeLa cells transfected with vector plasmids encoding various responsive elements"
Hitoshi Shiku, Michiaki Takeda, Tatsuya Murata, Uichi Akiba, Fumio Hamada, Tomokazu Matsue.
Anal. Chim. Acta, 640, (2009), 87-92.
10.1016/j.aca.2009.03.018

"Entrapment and measurement of a biologically functionalized microbead with a microwell electrode"
Ching-Yu Chang,Yasufumi Takahashi, Tatsuya Murata, Hitoshi Shiku, Hsien-Chang Chang, Tomokazu Matsue
Lab Chip, 9, (2009), 1185-1192.
10.1039/b817705h

"Electrochemical detection of epidermal growth factor receptors on a single living cell surface by scanning electrochemical microscopy"
Y. Takahashi, T. Miyamoto, H. Shiku, R. Asano, T. Yasukawa, I. Kumagai, T. Matsue.
Anal. Chem., 81(7), (2009), 2785-2790.
10.1021/ac900195m

"Simple and rapid preparation of vertically aligned gold nanoparticle arrays and fused nanorods in pores of alumina membrane based on positive dielectrophoresis"
Hyun Jung Lee, Tomoyuki Yasukawa, Masato Suzuki, Sang Hyun Lee, Takafumi Yao, Yusuke Taki, Akira Tanaka, Masaomi Kameyama, Hitoshi Shiku, Tomokazu Matsue.
Sens. Actuat. B, 136, (2009), 320-325.
10.1016/j.snb.2008.12.054

"A microfluidic dual capillary probe to collect messenger RNA from adherent cells and spheroids"
Hyun Jung Lee, Tomoyuki Yasukawa, Masato Suzuki, Sang Hyun Lee, Takafumi Yao, Yusuke Taki, Akira Tanaka, Masaomi Kameyama, Hitoshi Shiku, Tomokazu Matsue.
Analytical Biochemistry, 385, (2009), 138-142.
10.1016/j.ab.2008.10.039

"Electrochemical characterization of enzymatic activity of yeast cells entrapped in a poly(dimethylsiloxane) microwell on the basis of limited diffusion system"
Hitoshi Shiku, Shun Goto, Sungbong Jung, Kuniaki Nagamine, Masahiro Koide, Tomosato Itayama, Tomoyuki Yasukawa, Tomokazu Matsue.
Analyst, 34, (2009), 182-187.
10.1039/B808428A

"Detection of pesticide residues using an immunodevice based on negative dielectrophoresis"
Javier Ramon-Azcon, Ryouta Kunikata, F. -J. Sanchez, M. -P. Marco, Hitoshi Shiku, Tomoyuki Yasukawa, Tomokazu Matsue.
Biosens. Bioelectron., 24, (2009), 1592-1597.
10.1016/j.bios.2008.08.035

"Electrochemical gene-function analysis for single cells with addressable electrode/microwell arrays"
Zhenyu Lin, Yasufumi Takahashi, Tatsuya Murata, Michiaki Takeda, Kosuke Ino. Hitoshi Shiku, Tomokazu Matsue.
Angew. Chem. Int. Ed., 48, (2009), 2044-2046.
10.1002/anie.200805743


2008

"バイオチップの走査型電気化学顕微鏡解析"
安川智之, 珠玖 仁, 水谷文雄, 末永智一.
表面技術, 59(12), (2008), 818-824

"An addressable microelectrode array for electrochemical detection"
Zhenyu Lin, Yasufumi Takahashi, Yusuke Kitagawa, Taizo Umemura, Hitoshi Shiku, Tomokazu Matsue.
Anal. Chem. , 80, (2008), 6830-6833.
10.1021/ac801389d

"Cell-based electrochemical assay for endotoxin using a secreted alkaline phosphatase reporter system"
K. Y. Inoue, T. Yasukawa, H. Shiku, T. Matsue.
Electrochemistry, 78(8), (2008), 525-528.
10.5796/electrochemistry.76.525

"Rapid and separation-free sandwich immunosensing based on accumulation of microbeads by negative dielectrophoresis"
H. J. Lee, T. Yasukawa, H. Shiku, T. Matsue.
Biosens. Bioelectron., 24, (2008), 1000-1005.
10.1016/j.bios.2008.08.002

"Negative dielectrophoretic patterning with different cell types"
Masato Suzuki, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
Biosens. Bioelectron., 24, (2008), 1043-1047.
10.1016/j.bios.2008.06.051

"細胞機能を利用するマイクロバイオセンサ in 先進化学センサ(第2章、第1節)"
井上(安田)久美,珠玖 仁,末永智一
株式会社ティー・アイ・シィー出版, (2008)

"走査型電気化学顕微鏡による体外培養胚のクオリティ評価"
伊達安基, 阿部宏之, 珠玖 仁, 末永智一
財バイオインダストリー協会 バイオサイエンスとインダストリー, 66(6), (2008), 298-299.

"Electrophoretic cell manipulation and electrochemical gene-function analysis based on a yeast two-hybrid system in a microfluidic device"
Tomoyuki Yasukawa, Kuniaki Nagamine, Yoshiko Horiguchi, Hitoshi Shiku, Masahiro Koide, Tomoaki Itayama, Fujio Shiraishi, Tomokazu Matsue.
Anal. Chem.,80, (2008), 3722-3727.
10.1021/ac800143t

"Bioelectrochemistry: fundamentals, experimental techniques, and applications, (Eds. P. N. Bartlett) (Chapter 7,Whole-cell biosensors, p. 249-266)"
H. Shiku, K. Nagamine, T. Kaya, T. Yasukawa, T. Matsue.
John Wiley & Sons Ltd., West Sussex, UK, (2008).
ISBN978-0-470-84364-2

"Rapid fabrication of nanoparticles array on polycarbonate membrane based on positive dielectrophoresis"
Hyun Jung Lee, Tomoyuki Yasukawa, Masato Suzuki, Yusuke Taki, Akira Tanaka, Masaomi Kameyama, Hitoshi Shiku, Tomokazu Matsue.
Sens. Actuat. B, 131, (2008), 424-431.
10.1016/j.snb.2007.11.051


2007

"Measurement of gene expression from single adherent cells and spheroids using fast electrical lysis"
Yuji Nashimoto, Yasufumi Takahashi, Takeshi Yamakawa, Yu-suke Torisawa, Tomoyuki Yasukawa, Takahiro Ito-Sasaki, Masaki Yokoo, Hiroyuki Abe, Hitoshi Shiku, Hideki Kambara, Tomokazu Matsue.
Analyitical Chemistry, 79, (2007), 6823-6830.
10.1021/ac071050q

"Microfluidic chip integrated with amperometric detector array for in situ estimating oxygen consumption characteristics of single bovine embryos"
Ching-Chou Wu, Takeshi Saito, Tomoyuki Yasukawa, Hitoshi Shiku, Hiroyuki Abe, Hiroyoshi Hoshi, Tomokazu Matsue.
Sens. Actuat. B, 125, (2007), 680-687.
10.1016/j.snb.2007.03.017

"A competitive immunochromatographic assay for testosterone based on electrochemical detection"
Kumi Inoue,Pascal Ferrante, Yu Hirano, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
Talanta, 73, (2007), 886-892.
10.1016/j.talanta.2007.05.008

"Microcontact printed diaphorase monolayer on glass characterized by atomic force microscopy and scanning electrochemical microscopy"
Hong Qun Luo, Hitoshi Shiku, Ayako Kumagai, Yasufumi Takahashi, Tomoyuki Yasukawa, Tomokazu Matsue.
Electrochem. Comm., 9, (2007), 2703-2708.
10.1016/j.elecom.2007.08.024

"Enzyme immunosensing of pepsinogens 1 and 2 by scanning electrochemical microscopy"
Tomoyuki Yasukawa, Yu Hirano, Naomi Motochi, Hitoshi Shiku, Tomokazu Matsue.
Biosens. Bioelectron., 22, (2007), 3099-310.
10.1016/j.bios.2007.01.015

"ニトロセルロース膜を抗体固定化担体とするテストステロンの電気化学的酵素免疫測定法"
井上久美、フェラント パスカル、平野 悠、安川智之、珠玖 仁、末永智一
分析化学, 56, (2007), 471-478.
10.2116/bunsekikagaku.56.471

"Regulation and characterization of the polarity of cells embedded in a reconstructed basement matrix using a three-dimensional micro-culture system"
Yu-suke Torisawa, Yuji Nashimoto, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
Biotechnol. Bioeng., 97(3), (2007), 615-621.
10.1002/bit.21274

"Flow sandwich-type immunoassay in microfluidic devices based on negative dielectrophoresis"
Tomoyuki Yasukawa, Masato Suzuki, Takashi Sekiya, Hitoshi Shiku, Tomokazu Matsue.
Biosens. Bioelectron., 22, (2007), 2730-2736.
10.1016/j.bios.2006.11.010

"Negative dielectrophoretic patterning with colloidal particles and en capsulation into a hydrogel"
Masato Suzuki, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
Langmuir, 23(7), (2007), 4088-4094.
10.1021/la063075a

"バイオ電気化学の実際-バイオセンサ・バイオ電池の実用展開"
高橋康史、珠玖 仁、安川智之、末永智一
第13章(生体分子の局所分析と電気化学イメージング)p. 207-227.
シーエムシー出版, (2007)

"Electrochemical screening of recombinant protein solubility in Escherichia coli using scanning electrochemical microscopy (SECM)"
Kuniaki Nagamine, Shiho Onodera, Ai Kurihara, Tomoyuki Yasukawa, Hitoshi Shiku, Ryutaro Asano, Izumi Kumagai, Tomokazu Matsue.
Biotechnol. Bioeng., 96(5), (2007), 1008-1013.
10.1002/bit.21173

"細胞分析電気化学デバイスとマイクロシステムの開発"
珠玖 仁、梨本裕司、鳥澤勇介、安川智之、末永智一
社団法 日本化学会 バイオテクノロジー部会 日本化学会 バイオテクノロジー部会 NEWS LETTER, 10(2), (2007), 7-8

"A multicellular spheroid array to realize spheroid formation, culture and viability assay on a chip"
Yu-suke Torisawa, Airi Takagi, Yuji Nashimoto, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
Biomaterials, 28(3), (2007), 559-566.
10.1016/j.biomaterials.2006.08.054


2006

"一細胞定量解析の最前線‐ライフサーベイヤ構築に向けて‐"
珠玖 仁、末永智一.
(第5章4節細胞操作のデバイスとマイクロシステム).
シーエムシー出版, (2006)

"走査型電気化学顕微鏡を用いるC反応性タンパクの酵素"
安川智之、平野悠、小笠原大知、本地直美、珠玖仁、川端荘平、末永智一.
分析化学, 55(12), (2006)

"Topographic, electrochemical, and optical images captured using standing approach mode scanning electrochemical/optical microscopy"
Yasufumi Takahashi, Yu Hirano, Tomoyuki Yasukawa, Hitoshi Shiku, Hiroshi Yamada, Tomokazu Matsue
Langmuir, 22(25), (2006), 10299-10306.
10.1021/la0611763

"呼吸量測定によるウシ体外培養胚の品質評価と半自動計測装置の開発"
青柳重夫、内海陽介、松平昌昭、山田 弘、甲地 優志、珠玖 仁、阿部宏之、星 宏良、末永智一
分析化学, 55(11), (2006), 847-854.
10.2116/bunsekikagaku.55.847

"Electrochemical monitoring of cellular signal transduction with secreted alkaline phosphatase reporter system"
Yu-suke Torisawa, Noriko Ohara, Kuniaki Nagamine, Shigenobu Kasai, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
Anal. Chem., 78(22), (2006), 7625-7631.
10.1021/ac060737s

"タンパク質のパターニングと界面現象の解析"
高橋康史、珠玖 仁、安川智之、末永智一
表面科学, 27(10), (2006), 613-616

"Oxygen consumption of cell suspension in a poly(dimethylsiloxiane) (PDMS) microchannel estimated by scanning electrochemical microscop"
Takeshi Saito, Ching-Chou Wu, Hitoshi Shiku, Tomoyuki Yasukawa, Masaki Yokoo, Takashi Ito-Sasaki, Hiroyuki Abe, Hiroyoshi Hoshi, Tomokazu Matsue.
Analyst, 131(9), (2006), 1006-1011.
10.1039/b600080k

"「電気化学:測定と解析のてびき」プローブ法(1)走査型電気化学顕微鏡(SECM)・走査型振動電極法(SVET)"
青柳重夫、内海陽介、福泉敦尚、珠玖 仁、末永智一.
Electrochemistr, 74(9), (2006), 787-790
10.5796/electrochemistry.74.787

"Cytokine assay on a cellar chip by combining collagen gel embedded culture with scanning electrochemical microscopy"
Shigenobu Kasai, Hitoshi Shiku, Yu-suke Torisawa, Kuniaki Nagamine, Tomoyuki Yasukawa, Toshiaki Watanabe, Tomokazu Matsue.
Anal. Chim. Acta, 566(1), (2006), 55-59.
10.1016/j.aca.2006.02.016

"Oxygen permeability for surface-modified poly(dimethylsiloxane) characterized by scanning electrochemical microscopy"
Hitoshi Shiku, Takeshi Saito, Ching-Chou Wu, Tomoyuki Yasukawa, Masaki Yokoo, Hiroyuki Abe, Tomokazu Matsue, Hiroshi Yamada.
Chemistry Letters, 35(2), (2006), 234-235.
10.1246/cl.2006.234

"Electrochemical microbiosensors using living cells"
Tomokazu Matsue, Hitoshi Shiku.
Electrochemistry, 74(2), (2006), 107-113.
10.5796/electrochemistry.74.107

"Electrochemical mutagen screening with microbial chip"
Nobuto Matsui, Takatoshi Kaya, Kuniaki Nagamine, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
Biosensors and Bioelectronics, 21, (2006), 1202-1209.
10.1016/j.bios.2005.05.004

"Electrochemical microdevice with separable electrode and antibody chips for simultaneous detection of pepsinogens 1 and 2"
Daichi Ogasawara, Yu Hirano, Tomoyuki Yasukawa, Hitoshi Shiku, Kiichirou Kobori, Koji Ushizawa, Shohei Kawabata, Tomokazu Matsue.
Biosens. Bioelectron., 21, (2006), 1784-1790.
10.1016/j.bios.2005.09.009


2005

"誘電泳動法による微小流体中での微生物の生死分離"
鈴木雅登,安川智之,珠玖 仁,末永智一
分析化学, 54(12), (2005), 1189-1195
10.2116/bunsekikagaku.54.1189

"チオニン修飾金ナノ粒子を用いた電極表面の機能化と電気化学的グルコースセンサへの応用"
安川智之、モハメド カムルル イスラム、大橋拓矢、須藤 順、珠玖 仁、末永智一
表面技術, 56(10), (2005), 60-65

"Fabrication of miniature clark oxygen sensor integrated with microstructure"
Ching-Chou Wu, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
Sens. Actuat. B,110, (2005), 342-349.
10.1016/j.snb.2005.02.014

"Real-time monitoring of reactive oxygen species production during differentiation of human monocytic cell lines (THP-1)"
Shigenobu Kasai, Hitoshi Shiku, Yu-suke Torisawa, Hiroyuki Noda, Jun Yoshitake, Takuo Shiraishi, Tomoyuki Yasukawa, Toshiaki Watanabe, Tomokazu Matsue, Tetsuhiko Yoshimura.Anal.
Chim. Acta, 549, (2005), 14-19.
10.1016/j.aca.2005.06.034

"On-chip transformation of bacteria"
Kuniaki Nagamine, Shiho Onodera, Yu-suke Torisawa, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
Analytical Chemistry, 77, (2005), 4278-4281.
10.1021/ac048278n

Amperometric detection of the bacterial metabolic regulation with a microbial array chip. Biosensors and Bioelectronics, 21(1), (2005), 145-151. Kuniaki Nagamine, N. Matsui, T. Kaya, T. Yasukawa, H. Shiku, T. Nakayama, T. Nishino, T. Matsue.
10.1016/j.bios.2004.08.039

Application of microbial chip for amperometric detection of metabolic alteration in bacteria.
Sens. Actuat. B, 108, (2005), 676-682.
Kuniaki Nagamine, Takatoshi Kaya, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
10.1016/j.snb.2004.10.050

Metabolic and enzymatic activities of individual cells, spheroids, and embryos as a function of the sample size.
Sens. Actuat. B, 108, (2005), 597-602.
Hitoshi Shiku, Yu-suke Torisawa, Airi Takagi, Shigeo Aoyagi, Hiroyuki Abe, Hiroyoshi Hoshi, Tomoyuki Yasukawa, Tomokazu Matsue.
10.1016/j.snb.2004.12.030

Three-dimensional micro-culture system with a silicon based cell array device for multi-channel drug sensitivity test.
Sens. Actuat. B, 108, (2005), 654-659.
Yu-suke Torisawa, Hitoshi Shiku, Tomoyuki Yasukawa, Matsuhiko Nishizawa, Tomokazu Matsue.
10.1016/j.snb.2004.11.045

A multicellular spheroid-based drug sensitivity test by scanning electrochemical microscopy.
Oncology Reports, 13(6), (2005), 1107-1112.
Yu-suke Torisawa, Airi Takagi, Hitoshi Shiku, Tomoyuki Yasukawa, Tomokazu Matsue.
10.3892/or.13.6.1107

Multi-channel 3D cell culture device integrated on a silicon chip for anticancer drug sensitivity test.
Biomaterials, 26, (2005), 2165-2172.
Yu-suke Torisawa, Hitoshi Shiku, Tomoyuki Yasukawa, Matsuhiko Nishizawa, Tomokazu Matsue.
10.1016/j.biomaterials.2004.05.028


2004

Dielectrophoretic micropatterning with microparticle monolayers covalently linked to glass surfaces.
Langmuir, 20(25), (2004), 11005-11011. Masato Suzuki, Tomoyuki Yasukawa, Yoshiaki Mase, Daisuke Oyamatsu, Hitoshi Shiku, Tomokazu Matsue.
10.1021/la048111p

電気化学 オンチップ遺伝子工学: オンチップ培養とその評価.
ぶんせき, 2004(11), (2004), 671-673
彼谷高敏、珠玖 仁、安川智之、末永智一.

Respiration activity of single embryos entrapped in a cone-sheped microwell monitored by scanning electrochemical microscopy.
Anal. Chim. Acta, 522(1), (2004), 51-58.
Hitoshi Shiku, Takuo Shiraishi, Shigeo Aoyagi, Yousuke Utsumi, Masahki Matsudaira, Hiroyuki Abe, Hiroyoshi Hoshi, Shigenobu Kasai, Hiroaki Ohya, Tomokazu Matsue.
10.1016/j.aca.2004.06.054

バイオチップの最新技術と応用(4章第1節(細胞・微生物チップの開発)p. 179-191)
シーエムシー出版, (2004)
彼谷高敏、安川智之、珠玖 仁、末永智一.

Respiration activity of escherichia coli entrapped in a cone-shaped microwell and cylindrical micropore monitored by scanning electrochemical microscopy (SECM).
Analyst, 129(6), (2004), 529-534.
Takatoshi Kaya, Daisuke Numai, Kuniaki Nagamine, Shigeo Aoyagi, Hitoshi Shiku, Tomokazu Matsue
10.1039/B316582E

細胞チップを用いるバイオアッセイ.
分析化学, 53(5), (2004), 367-382
鳥澤勇介、珠玖 仁、安川智之、末永智一.
10.2116/bunsekikagaku.53.367

Proliferation assay on a silicon chip applicable for tumors extirpated from mammalians.
International Journal of Cancer, 109, (2004), 302-308.
Yu‐suke Torisawa, Hitoshi Shiku, Shigenobu Kasai, Matsuhiko Nishizawa, Tomokazu Matsue.
10.1002/ijc.11693

走査型電気化学顕微鏡のセンサへの利用と距離制御による高解像度化
Electrochemictry, 72(2), (2004), 137-142
平野 悠、小谷松大祐、安川智之、珠玖 仁、末永智一.

On chip electrochemical measurement of b-galactosidase expression using a microbial chip.
Chemical Communication, (2004), 248-249. Takatoshi Kaya, Kuniaki Nagamine, Nobuto Matsui, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu Matsue.
10.1039/b312462b

電気化学顕微鏡を用いた細胞計測法の実用化をめざして
生物物理, 44(1), (2004), 36-39
安川智之、鳥澤勇介、珠玖 仁、末永智一.
In vitro culture and evaluation techniques of embryos for production of high quality bovine embryos.
J. Mamm. Ova Res, 21, (2004), 22-30.
Hiroyuki Abe, Hitoshi Shiku, Shigeo Aoyagi, Hiroyoshi Hoshi.
10.1274/jmor.21.22


2003

Fabrication of microbial chip using collagen gel microstructure.
Lab on a Chip, 3, (2003), 313-317.
Takatoshi Kaya, Kuniaki Nagamine, Daisuke Oyamatsu, Hitoshi Shiku, Matsuhiko Nishizawa, Tomokazu Matsue.
10.1039/b309349b

Characterization of the peroxidase activity of single algae protoplasts by scanning electrochemical microscopy.
Bulletin of the Chemical Society of Japan, 76(9), (2003), 1757-1762.
Huafang Zhou, Shigenobu Kasai, Hiroyuki Noda, Hiroaki Ohya-Nishiguchi, Hitoshi Shiku, Tomokazu Matsue.
10.1246/bcsj.76.1757

Electrochemical / photochemical formation of enzyme patterns on glass substrates using a scanning electrochemical / confocal microscope.
Sensores and Actuators, B, 91, (2003), 199-204.
Daisuke Oyamatsu, Norihiro Kanaya, Hitoshi Shiku, Matsuhiko Nishizawa, Tomokazu Matsue.
10.1016/S0925-4005(03)00089-3


2002

Encyclopedia of electrochemistry (Chapter 8 (Scanning electrochemical microscopy applied to biological systems)).
Wiley-VCH, (2002).
H. Shiku, H. Ohya, T. Matsue.

Simultaneous detection of uric acid and glucose on a dual-enzyme chip using scanning electrochemical microscopy/scanning chemiluminescence microscopy.
Anal. Chim. Acta, 458, (2002), 263-270.
Shigenobu Kasai, Yu Hirano, Naomi Motochi, Hitoshi Shiku, Matsuhiko Nishizawa, Tomokazu Matsue.
10.1016/S0003-2670(02)00064-8

ウシ胚におけるミトコンドリアの形態変化と胚の品質評価.
日本胚移植学雑誌, 24(1), (2002), 19-27
阿部宏之、珠玖 仁、星 宏良.


2001

Mapping peroxidase in plant tissues by scanning electrochemical microscopy.
Bioelectrochemistry, 54, (2001), 151-156.
Huafang Zhou, Hitoshi Shiku, Shigenobu Kasai, Hiroyuki Noda, Tomokazu Matsue, Hiroaki Ohya-Nishiguchi, Hitoshi Kamada
10.1016/S1567-5394(01)00123-2

測定法講座/その場測定法/走査型電気化学顕微鏡.
Electrochemistry, 69(10), (2001), 806-810
珠玖 仁、大矢博昭、末永智一.

Oxygen consumption of single bovine embryos probed by scanning electrochemical microscopy.
Analytical Chemistry, 73(15), (2001), 3751-3758.
Hitoshi Shiku, Takuo Shiraishi, Hiroaki Ohya, Tomokazu Matsue, Hiroyuki Abe, Hiroyoshi Hoshi, Masato Kobayashi.
10.1021/ac010339j


2000

Monitoring activity of living cells entrapped in a membrane-sealed microcapillary with scanning electrochemical microscopy.
Electrochemistry, 68(11), (2000), 890-892.
H. Shiku, T. Shiraishi, H. Ohya, T. Matsue, H. Abe, H. Hoshi, M. Kobayashi.

Sensors Update Vol. 6(Chap. 12 (Microamperometric sensing of localized biomolecules)).
Sensors Update Vol. 6, Wiley-VCH, (2000).
H. Shiku, T. Matsue.
電気化学顕微鏡の基礎と応用.
表面技術, 51(1), (2000), 46-52.
珠玖 仁、大矢博昭、末永智一.


1999

微小空間の電気化学_走査型電気化学顕微鏡による生体分子機能表面の構築と評価.
化学, 54(11), (1999), 72-73.
珠玖 仁、大矢博昭、末永智一.

Noncontact near-field scanning optical microscopy imaging using an interferometric optical feedback mechanism.
Langmuir, 15, (1999), 2162-2168.
Hitoshi Shiku, Jeffrey R. Krogmeier, Robert C. Dunn
10.1021/la981198s

Domain formation in thin lipid films probed with near-field scanning optical microscopy.
Microscopy, 194, (1999), 455-460.
Hitoshi Shiku, R. C. Dunn
10.1046/j.1365-2818.1999.00526.x

Near-field scanning optical microscopy studies of L-alpha-dipalmitoylphosphatidylcholine monolayers at the air/liquid interface.
J. Microscopy, 194, (1999), 461-466.
Hitosi Shiku, R. C. Dunn.

10.1046/j.1365-2818.1999.00525.x

Near-field scanning optical microscopy.
Anal. Chem., 71, (1999), 23A-29A.
H. Shiku, R. C. Dunn.


1998

Probing biological systems with near-field optics.
Proc. Soc. Photo-Opt. Instrum. Eng., 3273, (1998), 156-164.
H. Shiku, C. W. Hollars, M. A. Lee, C. E. Talley, G. Cooksey, R. C. Dunn.

Direct observation of DPPC domain motion on mica surface under conditions of high relative humidity.
Phys. Chem. B, 102, (1998), 3791-3797.
Hitoshi Shiku, Robert C. Dunn.
10.1021/jp9808330


1997

Microfabrication of alkylsilanized glass substrate by electrogenerated hydroxyl radical using scanning electrochemical microscopy.
Langmuir, 13, (1997), 7239-7244.
Hitoshi Shiku, Isamu Uchida, Tomokazu Matsue.
10.1021/la970554o

Dual-immunoassay of human chorionic gonadotropin and human placental lactogen on microfabricated glass substrates by scanning electrochemical microscopy.
J. Electroanal. Chem, 438, (1997), 187-190.
Hitoshi Shiku, Yoshitake Hara, Tomokazu Matsue, Isamu Uchida, Tadakazu Yamauchi.
10.1026/S0022-0728(96)04979-0

Microfabrication and characterization of solid surfaces patterned with enzymes or antigen-antibodies by scanning electrochemical microscopy.
American Chemical Society Symposium Series, 656, (1997), 202-209.
Hitoshi Shiku, Yoshitake Hara, T. Takeda, T. Matsue, I. Uchida.


1996

Detection of microspotted carcinoembryonic antigen on a glass substrate by scanning electrochemical microscopy.
Anal. Chem.., 68, (1996), 1276-1278.
Hitoshi Shiku, Tomokazu Matsue, Isamu Uchida.
10.1021/ac950824c


1995

Microfabrication and characterization of diaphorase-patterned surfaces by scanning electrochemical microscopy.
Anal. Chem., 67(2), (1995), 312-317.
Hitoshi Shiku, Toshihiro Takeda, Hiroshi Yamada, Tomokazu Matsue, Isamu Uchida.
10.1021/ac00098a014


1994

Permselectivity of voltage-gated alamethicin ion channel studies by microamperometry.
J. Phys. Chem., 98, (1994), 11001-11003.
H. Yamada, H. Shiku, T. Matsue, I. Uchida.

Microvoltammetric characterization of diaphorase monolayer at glass surfaces.
Bioelectrochem. Bioenerg. (Presently Bioelectrochemistry), 33, (1994), 91-93.
Hiroshi Yamada, Hitoshi Shiku, Tomokazu Matsue, Isamu Uchida.
10.1016/0302-4598(94)87038-1


1993

Electron transfer at a planar bilayer lipid membrane incorporated with 7,7,8,8-tetracyanoquinodimethane studied by ac impedance spectroscopy.
J. Phys. Chem., 97, (1993), 9547-9549.
H. Yamada, H. Shiku, T. Matsue, I. Uchida.

Ion and electron transport across a planar bilayer lipid membrane.
Redox Mechanism and Interfacial Properties of Molecules of Biological Importance, 93-11, (1993), 290-298.
T. Matsue, H. Yamada, H. Shiku, I. Uchida

Determination of active diaphorase immobilized at electrode surfaces.
Bioelectrochem. Bioenerg. (Presently Bioelectrochemistry), 29, (1993), 337-346.
Hiroshi Yamada, Hitoshi Shiku, Tomokazu Matsue, Isamu Uchida