中山研究室/Nakayama Laboratory 東北大学大学院工学研究科バイオ工学専攻応用生命化学講座

論文出版 List of publications

2020 Molecular mechanisms of natural rubber biosynthesis [Annual Review of Biochemistry 89 in press (2020)] Seiji Takahashi A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity. [Nature communications 11(1) 870 - 870 (2020)] Toshiyuki Waki, Ryo Mameda, Takuya Nakano, Sayumi Yamada, Miho Terashita, Keisuke Ito, Natsuki Tenma, Yanbing Li, Naoto Fujino, Kaichi Uno, Satoshi Yamashita, Yuichi Aoki, Konstantin Denessiouk, Yosuke Kawai, Satoko Sugawara, Kazuki Saito, Keiko Yonekura-Sakakibara, Yasumasa Morita, Atsushi Hoshino, Seiji Takahashi, Toru Nakayama https://doi.org/10.1038/s41467-020-14558-9 2019 Glycoside-specific glycosyltransferases catalyze regio-selective sequential glucosylations for a sesame lignan, sesaminol triglucoside. [The Plant journal : for cell and molecular biology (2019)] Ono E, Waki T, Oikawa D, Murata J, Shiraishi A, Toyonaga H, Kato M, Ogata N, Takahashi S, Yamaguchi MA, Horikawa M, Nakayama T https://doi.org/10.1111/tpj.14586 ダイズの5‐デオキシ型イソフラボノイド生合成におけるメタボロン形成の役割細胞内フラボノイド代謝の高効率化 [化学と生物 57(10) 593‐595 (2019)] 和氣駿之, 高橋征司, 中山亨 Formation of Flavonoid Metabolons: Functional Significance of Protein-Protein Interactions and Impact on Flavonoid Chemodiversity. [Frontiers in plant science 10 821 (2019)] Nakayama T, Takahashi S, Waki T https://doi.org/10.3389/fpls.2019.00821 Distinctive structural motifs co‐ordinate the catalytic nucleophile and the residues of the oxyanion hole in the alpha/beta‐hydrolase fold enzymes. [Protein Science, 28(2) 344-364 (2019)] Polytimi S. Dimitriou, Alexander I. Denesyuk, Toru Nakayama, Mark S. Johnson, Konstantin Denessiouk https://doi.org/10.1002/pro.3527 2018 Identification and characterization of a novel bacterial β-glucosidase that is highly specific for the β-1,2-glucosidic linkage of sesaminol triglucoside. [Bioscience, biotechnology, and biochemistry 82(9) 1518 - 1521 (2018)] Sakurai A, Hongo S, Nair A, Waki T, Oikawa D, Nishio T, Shimoyama T, Takahashi S, Yamashita S, Nakayama T https://doi.org/10.1080/09168451.2018.1476123 フラボノイド代謝酵素複合体：フラボノイドメタボロン [バイオサイエンスとインダストリー 76(5) 390 - 394 (2018)] 和氣駿之, 高橋征司, 中山亨天然ゴム生合成機構の解明と試験管内ゴム合成 [バイオサイエンスとインダストリー 76(4) 328 - 329 (2018)] 高橋征司 Involvement of chalcone reductase (CHR) in the soybean isoflavone metabolon: Identification of GmCHR5 that interacts with 2-hydroxyisoflavanone synthase. [The Plant journal, 96(1) 56 - 74 (2018)] Ryo Mameda, Toshiyuki Waki, Yosuke Kawai, Seiji Takahashi, Toru Nakayama Abstract Identification and characterization of a novel bacterial β-glucosidase that is highly specific for the β-1,2-glucosidic linkage of sesaminol triglucoside. [Bioscience, Biotechnology, and Biochemistry, (2018)] Akinori Sakurai, Shuntaro Hongo, Arun Nair, Toshiyuki Waki, Daiki Oikawa, Takuma Nishio, Takefumi Shimoyama, Seiji Takahashi, Satoshi Yamashita, Toru Nakayama Abstract Physical interactions among flavonoid enzymes in snapdragon and torenia reveal the diversity in the flavonoid metabolon organization of different plant species. [The Plant Journal, 94, (2018), 372-392] Naoto Fujino, Natsuki Tenma, Toshiyuki Waki, Keisuke Ito, Yuki Komatsuzaki, Keigo Sugiyama, Tatsuya Yamazaki, Saori Yoshida, Masayoshi Hatayama, Satoshi Yamashita, Yoshikazu Tanaka, Reiko Motohashi, Konstantin Denessiouk, Seiji Takahashi, Toru Nakayama Abstract 2017 Purification and characterization of small and large rubber particles from Hevea brasiliensis. [Bioscience, Biotechnology, and Biochemistry, 82(6), (2017), 1011-1020] Satoshi Yamashita, Makie Mizuno, Hidehiko Hayashi, Haruhiko Yamaguchi, Yukino Miyagi-inoue, Kazuhisa Fushihara, Tanetoshi Koyama, Toru Nakayama, Seiji Takahashi Abstract バイオ工学を駆使した天然ゴムの合成：生合成機構の解明と安定供給に大きく前進. [化学, 72(8), (2017), 12-16] 和氣駿之, 山下哲, 中山亨, 高橋征司 Alpha/beta-hydrolases: A unique structural motif coordinates catalytic acid residue in 40 protein fold families. [Proteins: Structure, Function, and Bioinformatics, 85(10), (2017), 1845-1855] Polytimi S. Dimitriou, Alexander Denesyuk, Seiji Takahashi, Satoshi Yamashita, Mark S. Johnson, Toru Nakayama, Konstantin Denessiouk Abstract バイオ資源の探索研究. [化学と教育, 65(1), (2017), 12-15] 中山亨, 和氣駿之, 高橋征司明らかになりつつある天然ゴム生合成の分子機構 [バイオサイエンスとインダストリー 75(4) 292 - 298 (2017)] 高橋征司, 山下哲 2016 Identification and reconstitution of the rubber biosynthetic machinery on rubber particles from Hevea brasiliensis.[eLife 5,e19022(2016)]Satoshi Yamashita, Haruhiro Yamaguchi, Toshiyuki Waki, Yuichi Aoki, Makie Mizuno, Fumihiro Yanbe, Tomoki Ishii, Ayuta Funaki, Yuzuru Tozawa, Yukino Miyagi-Inoue, Kazuhisa Fushihara, Toru Nakayama, Seiji Takahashi Abstract Ecophysiological consequences of alcoholism on human gut microbiota: implications for ethanol-related pathogenesis of colon cancer.[ Scientific Reports 6, Article number: 27923 (2016)] Atsuki Tsuruya, Akika Kuwahara, Yuta Saito, Haruhiko Yamaguchi, Takahisa Tsubo, Shogo Suga, Makoto Inai, Yuichi Aoki, Seiji Takahashi, Eri Tsutsumi, Yoshihide Suwa, Hidetoshi Morita, Kenji Kinoshita, Yukari Totsuka, Wataru Suda, Kenshiro Oshima, Masahira Hattori, Takeshi Mizukami, Akira Yokoyama, Takefumi Shimoyama & Toru Nakayama Abstract Major Anaerobic Bacteria Responsible for the Production of Carcinogenic Acetaldehyde from Ethanol in the Colon and Rectum.[ Alcohol and Alcoholism, 2016, 51(4) 395-401] Atsuki Tsuruya, Akika Kuwahara, Yuta Saito, Haruhiko Yamaguchi, Natsuki Tenma, Makoto Inai, Seiji Takahashi, Eri Tsutsumi, Yoshihide Suwa, Yukari Totsuka, Wataru Suda, Kenshiro Oshima, Masahira Hattori, Takeshi Mizukami, Akira Yokoyama, Takefumi Shimoyama, and Toru Nakayama Abstract Identification of protein-protein interactions of isoflavonoid biosynthetic enzymes with 2-hydroxyisoflavanone synthase in soybean (Glycine max (L.) Merr.).[ Biochemical and Biophysical Research Communications 469 (2016) 546e551]Toshiyuki Waki, DongChan Yoo, Naoto Fujino, Ryo Mameda, Konstantin Denessiouk, Satoshi Yamashita, Reiko Motohashi, Tomoyoshi Akashi, Toshio Aoki, Shin-ichi Ayabe, Seiji Takahashi, Toru Nakayama Abstract Transformation and isoflavonoid analyses of suspension-cultured cells of soybean [Glycine max (L.) Merr. cv. Enrei].[ Plant Biotechnology 33, 137-141 (2016)]Toshiyuki Waki, Seiji Takahashi, Toru Nakayama Abstract 2015 Achievements and Perspectives in Biochemistry Concerning Anthocyanin Modification for Blue Flower Coloration.[Plant & Cell Physiology,56(1),(2015),28-40]Nobuhiro Sasaki and Toru Nakayama Abstract Identification of a highly specific isoflavone 7-O-glucosyltransferase in the soybean (Glycine max (L.) Merr.).[ Plant & Cell Physiology, 56(8), (2015), 1512-1520]Ayuta Funaki, Toshiyuki Waki, Akio Noguchi, Yosuke Kawai, Satoshi Yamashita, Seiji Takahashi and Toru Nakayama Abstract Developmental and nutritional regulation of isoflavone secretion from soybean roots.[Bioscience, Biotechnology, and Biochemistry,(2015)]Akifumi Sugiyama, Yumi Yamazaki, Kazuaki Yamashita, Seiji Takahashi, Toru Nakayama and Kazufumi Yazaki 10.1080/09168451.2015.1062714 Abstract 2014 Structural Insights into the Low pH Adaptation of a Unique Carboxylesterase from Ferroplasma: ALTERING THE pH OPTIMA OF TWO CARBOXYLESTERASES.[The Journal of Biological Chemistry,289,(2014),24499-24510]Kazuhiro Ohara, Hideaki Unno, Yasuhiro Oshima, Miho Hosoya, Naoto Fujino, Kazutake Hirooka, Seiji Takahashi, Satoshi Yamashita, Masami Kusunoki, and Toru Nakayama Abstract 触媒機能を指標にした自然界からの酵素探索研究：セサミノール配糖体分解酵素の探索を例として.[生物工学,92, (2014), 411-414]山下哲, 下山武文, 高橋征司, 山口雅篤, 中山亨 Achievements and Perspectives in Biochemistry Concerning Anthocyanin Modification for Blue Flower Coloration.[Plant and Cell Physiology, (2014)]Nobuhiro Sasaki, Toru Nakayama Abstract Identification of laticifer-specific genes and their promoter regions from a natural rubber producing plant Hevea brasiliensis.[Plant Sci.,225,(2014),1-8]Yuichi Aoki, Seiji Takahashi, Daisuke Takayama, Yoshiyuki Ogata, Nozomu Sakurai, Hideyuki Suzuki, Kasem Asawatreratanakul, Dhirayos Wititsuwannakul, Rapepun Wititsuwannakul, Daisuke Shibata, Tanetoshi Koyama, Toru Nakayama Abstract cDNA cloning and characterization of chalcone isomerase-fold proteins from snapdragon (Antirrhinum majus L.) flowers.[Plant Biotechnology,31,(2014),105-114]Naoto Fujino1, Tatsuya Yamazaki1, Yanbing Li, Kota Kera, Erika Furuhashi, Satoshi Yamashita, Yasumasa Morita, Masayoshi Nakayama, Seiji Takahashi, Toru Nakayama Absract Paenibacillus relictisesami sp. nov., isolated from sesame oil cake.[International Journal of Systematic and Evolutionary Microbiology,64,(2014),1534-1539]Takefumi Shimoyama, Nurziha Binti Johari, Atsuki Tsuruya, Arun Nair, and Toru Nakayama Abstract 2013 Coordinated transcriptional regulation of isopentenyl diphosphate biosynthetic pathway enzymes in plastids by phytochrome-interacting factor 5.[Biochemical and Biophysical Research Communications,443,(2013),768-774]Kazuto Mannen, Takuro Matsumoto, Seiji Takahashi, Yuta Yamaguchi, Masanori Tsukagoshi, Ryosuke Sano, Hideyuki Suzuki, Nozomu Sakurai, Daisuke Shibata, Tanetoshi Koyama, Toru Nakayama Abstract ゴマリグナン「セサミノール」と微生物のセサミノール配糖体分解酵素.[BIO INDUSTRY,30(11), (2013), 56-63]中山亨・下山武文・山下哲・高橋征司セサミノール配糖体分解酵素の発見.[一般財団法人　バイオインダストリー協会　バイオサイエンスとインダストリー,71(5), (2013), 436-437]下山武文・高橋征司・中山亨ゴマの健康成分の生産につながる新しい酵素の発見.[化学,68(6), (2013), 73]中山亨・下山武文・山下哲・高橋征司 Purification, gene cloning, and biochemical characterization of a β-glucosidase capable of hydrolyzing sesaminol triglucoside from Paenibacillus sp. KB0549.[PLOS ONE,8(4),(2013),e60538-]Arun Nair, Akika Kuwahara, Akihiro Nagase, Haruhiko Yamaguchi, Tatsuya Yamazaki, Miho Hosoya, Ayano Omura, Kunio Kiyomoto, Masa-atsu Yamaguchi, Takefumi Shimoyama, Seiji Takahashi, Toru Nakayama Abstract UDP-glucuronic acid:flavonol-3-O-glucuronosyltransferase (VvGT5) from the grapevine Vitis vinifera.[Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.,69,(2013),65-68]Mizohata E, Okuda T, Hatanaka S, Nakayama T, Horikawa M, Nakayama T, Ono E, Inoue T Abstract Transcription analyses of GmICHG, a gene coding for a β-glucosidase that catalyzes the specific hydrolysis of isoflavone conjugates in Glycine max (L.) Merr.[Plant Sci.,208,(2013),10-19]DongChan Yoo, Takayuki Hara, Naoki Fujita, Toshiyuki Waki, Akio Noguchi, Seiji Takahashi, Toru Nakayama Glucosylation of hydroxyflavones by glucosyltransferases from Phytolacca americana.[J. Mol. Cat. B: Enzymatic,90,(2013),61-63]Tomoya Iwakiri, Shogo Mase, Tomonori Murakami, Masahiro Matsumoto, Hiroki Hamada, Toru Nakayama, Shin-ichi Ozaki Synthesis of 3,5,3',4'-tetrahydroxy-trans-stilbene-4'-O-beta-D-glucopyranoside by glucosyltransferases from Phytolacca americana.[Natural Product Communications,8(1),(2013),119-120]Tomoya Iwakiri, Hiroya Imai, Hiroki Hamada, Toru Nakayama, Shin-ichi Ozaki 飲酒習慣にともなう上部消化管の発がんリスク増大と口腔内アセトアルデヒド除去技術.[ILSI Japan,(113), (2013), 16-23]下山武文，鈴木幸雄，中山亨 Kumamolisin-As.[Academic Press　In: Neil D. Rawlings and Guy S. Salvesen, eds, Handbook of proteolytic enzymes 3rd edition,1, (2013), 3344-3347]Toru Nakayama 2012 Purification, characterization, and primary structure of a novel N-acyl-D-amino acid amidohydrolase from Microbacterium natoriense TNJL143-2.[J. Biosci. Bioengin.,114,(2012),391-397]Jian Liu, Yu Asano, Keiko Ikoma, Satoshi Yamashita, Yoshihiko Hirose, Takefumi Shimoyama, Seiji Takahashi, Toru Nakayama, and Tokuzo Nishino Abstract 　メタボロン…植物二次代謝工学におけるインパクト.[生物工学会誌,(9), (2012), 15-20]中山亨，兪東燦，高橋征司植物フラボノイドグリコシルトランスフェラーゼ：分子系統学と特異性発現機構.[酵素工学ニュース,(67), (2012), 6-10]中山亨，小埜栄一郎，堀川学 Catalytic removal of acetaldehyde in saliva by a Gluconobacter strain.[J. Biosci. Bioengin.,114,(2012),268-274]Haruhiko Yamaguchi, Miho Hosoya, Takefumi Shimoyama, Seiji Takahashi, Jian Feng Zhang, Eri Tsutsumi, Yukio Suzuki, Yoshihide Suwa, and Toru Nakayama Abstract 　 Regioselective glucosidation of trans-resveratrol in Escherichia coli expressing glucosyltransferase from Phytolacca americana.[Biotechnol. Lett.,34,(2012),475-481]Shin-ichi Ozaki, Hiroya Imai, Tomoya Iwakiri, Takehiro Sato, Kei Shimoda, Toru Nakayama, Hiroki Hamada Abstract　 Quantitative analyses of the behavior of exogenously added bacteria during an acidulocomposting process.[J. Biosci. Bioengin.,114,(2012),70-72]Takatoshi Suematsu, Satoshi Yamashita, Hisashi Hemmi, Ayaka Yoshinari, Takefumi Shimoyama, Toru Nakayama, and Tokuzo Nishino Abstract 平行進化する基質特異性.[化学と生物,50(1), (2012), 16-22]小埜栄一郎，堀川学，中山亨 Identification and characterization of a cis,trans-mixed heptaprenyl diphosphate synthase from Arabidopsis thaliana.[FEBS Journal,279,(2012),3813-3827]Kota Kera, Seiji Takahashi, Tsuyoshi Suto, Tanetoshi Koyama, Toru Nakayama Abstract 2011 Gene cloning and biochemical characterization of a catalase from Gluconobacter oxydans.[J. Biosci. Bioengin.,111,(2011),522-527]Haruhiko Yamaguchi, Keigo Sugiyama, Miho Hosoya, Seiji Takahashi, and Toru Nakayama 包括的転写制御による植物イソプレノイドの代謝工学.[生物工学,89, (2011), 649-652]高橋征司，古山種俊，中山亨 2010 Functional Differentiation of the Glycosyltransferases That Contribute to the Chemical Diversity of Bioactive Flavonol Glycosides in Grapevine (Vitis vinifera L. Plant Cell First published on August 6, 2010; Eiichiro Ono, Yu Homma, Manabu Horikawa, Satoshi Kunikane-Doi, Haruna Imai, Seiji Takahashi, Yosuke Kawai, Masaji Ishiguro, Yuko Fukui, and Toru Nakayama [Abstract] Production of tetraketide lactones by mutated Antirrhinum majus chalcone synthases (AmCHS1) Journal of Bioscience and Bioengineering 110 (2010) 158-164 Masayoshi Hatayama, Hideaki Unno, Masami Kusunoki, Seiji Takahashi, Tokuzo Nishino and Toru Nakayama 2009 New role of flavin as a general acid-base catalyst with no dedox function in type 2 isopentenyl-diphosphate isomerase The Journal of Biological Chemistry 284 (2009)　9160-9167 Hideaki Unno, Satoshi Yamashita, Yosuke Ikeda, Shin-ya Sekiguchi, Norie Yoshida, Tohru Yoshimura, Masami Kusunoki, Toru Nakayama, Tokuzo Nishino, Hisashi Hemmi Effect of mutagenesis at the region upstream from the G(Q/E) motif of three types of geranylgeranyl diphosphate synthase on product chain-length Journal of Bioscience and Bioengineering 107 (2009) 235-239 Motoyoshi Noike, Takashi Katagiri, Toru Nakayama, Tokuzo Nishino, Hisashi Hemmi Polymerase chain reaction-denaturing gradient gel electrophoresis analysis of microbial community structure in landoll leachate J. Hazard. Mater. 164 (2009) 1503-1508 Miho Uchida, Haruna Hatayoshi, Aoi Syuku-nobe, Takefumi Shimoyama, Toru Nakayama, Akitsugu Okuwaki, Tokuzo Nishino, Hisashi Hemmi Local differentiation of sugar donor speciocity of flavonoid glycosyltransferase in Lamiales Plant Cell 21 (2009) 1556-1572 Akio Noguchi, Manabu Horikawa, Yuko Fukui, Masako Fukuchi-Mizutani, Asako Iuchi-Okada, Masaji Ishiguro, Yoshinobu Kiso, Toru Nakayama, Eiichiro Ono Identification of an inducible glucosyltransferase from Phytolacca americana L. cells that are capable of glucosylating capsaicin Plant Biotechnol. 26 (2009) 285-292 Akio Nogichi, Satoshi Kunikane, Hiroaki Homma, Wenhai Liu, Takashi Sekiya, Miho Hosoya, Soonil Kwon, Shingo Ohiwa, Hisashi Katsuragi, Tokuzo Nishino, Seiji Takahashi, Hiroaki Hamada, Toru Nakayama Kinetic and thermodynamic characterization of the cold activity acquired upon single amino-acid substitution near the active site of a thermostable α-glucosidase Journal of Molecular Catalysis B: Enzymatic 56 (2009) 300-306 Akio Noguchi, Tokuzo Nishino, Toru Nakayama マメ科植物におけるイソフラボンの修飾 . 脱修飾を介した代謝調節：単離が進む関連酵素遺伝子群とその機能解明化学と生物 47 (2009) 160-162 高橋征司，中山亨 2008 A novel glucosylation enzyme: molecular cloning, expression, and characterization of Trichoderma viride JCM22452 alpha-Amylase and enzymatic synthesis of some flavonoid monoglucosides and oligoglucosides J. Agric. Food Chem. 56 (2008) 12016-12024 Noguchi A., Inohara-Ochiai M., Ishibashi N., Fukami H., Nakayama T., Nakao M. 花色調節技術への期待：アントシアニンアシル基転移酵素の機能と構造. 生物工学会誌 86(2008)171-173 中山亨 The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction The FEBS Journal 275 (2008) 3921-3933 Motoyoshi Noike, Takashi Katagiri, Toru Nakayama, Tanetoshi Koyama, Tokuzo Nishino and Hisashi Hemmi cDNA cloning of glycosyltransferases from Chinese wolfberry (Lycium barbarum L.) fruits and enzymatic synthesis of a catechin glucoside using a recombinant enzyme (UGT73A10) Journal of Molecular Catalysis B: Enzymatic 55 (2008) 84-92 Akio Noguchi, Nobuhiro Sasaki, Masahiro Nakaoa, Harukazu Fukami, Seiji Takahashi, Tokuzo Nishino, Toru Nakayama 好熱性コラーゲン分解酵素生産菌 Thermobifida sp. 4-2-1 株の分離とキャラクタリゼーション環境バイオテクノロジー学会誌 80 (2008) 99-103 大野正博，山口晴彦，高橋征司，中山亨植物二次代謝産物グリコシルトランスフェラーゼの構造と機能生化学 80 (2008) 1033-1038 國兼聡，中山亨植物二次代謝産物グリコシルトランスフェラーゼによる脂溶性有用物質のグリコシル化生物工学 86 (2008) 4 中山亨黄色フラボノイド色素，オーロンによる黄色花の分子育種化学と生物 46 (2008) 62-69 小埜栄一郎，福井祐子，中山亨 2007 A UDP-glucose:isoflavone 7-O-glucosyltransferase from the roots of soybean (Glycine max) seedlings:? PURIFICATION, GENECLONING, PHYLOGENETICS, AND AN IMPLICASTION FOR AN ALTERNATIVE STRATEGY OF ENZYME CATALYSIS The Journal of Biological Chemistry 282 (2007)　23581-23590 Akio Noguchi, Atsushi Saito, Yu Homma, Masahiro Nakao, Nobuhiro Sasaki, Tokuzo Nishino, Seiji Takahashi, and Toru Nakayama cDNA cloning of a BAHD acyltransferase from soybean (Glycine max): Isoflavone 7-O-glucoside-6’-O-malonyltransferase Phytochemistry 68 (2007) 2035-2042 Hirokazu Suzuki, Tokuzo Nishino, Toru Nakayama Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermiphilic archaeon Archaeoglobus fulgidus The FEBS Journal 274 (2007) 805-814 Motomichi Murakami, Kyohei Shibuya, Toru Nakayama, Tokuzo Nishino, Tohru Yoshimura and Hisashi Hemmi Structural and Mutational Studies of Anthocyanin Malonyltransferases Establish the Features of BAHD Enzyme Catalysis The Journal of Biological Chemistry　282 (2007) 15812-15822 Hideaki Unno, Fumiko Ichimaida, Hirokazu Suzuki, Seiji Takahashi, Yoshikazu Tanaka, Atsushi Saito, Tokuzo Nishino, Masami Kusunoki, and Toru Nakayama The QM/MM Molecular Dynamics and Free Energy Simulations of the Acylation Reaction Catalyzed by the Serine-Carboxyl Peptidase Kumamolisin-As. Biochemistry 46 (2007) 3784-3792 Qin Xu, Hao-Bo Guo, Alexander Wlodawer, Toru Nakayama, and Hong Guo Anthocyanin acyltransferase engineered for the synthesis of a novel polyacylated anthocyanin Plant Biotechnology 24 (2007) 495-501 Hirokazu Suzuki, Tokuzo Nishino, Toru Nakayama Molecular Breeding of Novel Yellow Flowers by Engineering the Aurone Biosynthetic Pathway Transgenic Plant Journal 1 (2007) 66-80 Eiichiro Ono, Toru Nakayama 植物フラボノイド，オーロンによる黄色花の分子育種ブレインテクノニュース 119 (2007) 19-25 小埜栄一郎，中山亨 Classical なアプローチバイオサイエンスとインダストリー 65 (2007) 33 中山亨 2006 Localization of a flavonoid biosynthetic polyphenol oxidase in vacuoles The Plant Journal, 45 (2006) 133-143. Eiichiro Ono, Masayoshi Hatayama, Yuri Isono, Takuya Sato, Ryoko Watanabe, Keiko Yonekura-Sakakibara, Masako Fukuchi-Mizutani, Yoshikazu Tanaka, Takaaki Kusumi, Tokuzo Nishino and Toru Nakayama Biochemical characterrization and mutational studies of a chalcone synthase from yellow snapdragon (Antirrhinum majus) flowers Plant Biotechnology, 23 (2006) 373-378. Masayoshi Hatayama, Eiichiro Ono, Keiko Yonekura-Sakakibara, Yoshikazu Tanaka, Tokuzo Nishino, Toru Nakayama Catalytic Role of Proton Transfers in the Formation of a Tetrahedral Adduct in a Serine Carboxyl Peptidase Biochemistry, 45 (2006) 9129-9137. Haobo Guo, Alexander Wlodawer, Toru Nakayama, Qin Xu, and Hong Guo Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site The FEBS Journal, 273, (2006) 2563-2576. Ayumi Okubo, Mi Li, Masako Ashida, Hiroshi Oyama, Alla Gustchina, Kohei Oda, Ben M. Dunn, Alexander Wlodawer and Toru Nakayama Yellow flowers generated by expression of the aurone biosynthetic pathway Proceedings of the National Academy of Sciences of the United States of America, 103 (2006) 11075-11080. Eiichiro Ono, Masako Fukuchi-Mizutani, Noriko Nakamura, Yuko Fukui, Keiko Yonekura-Sakakibara, Masaatsu Yamaguchi, Toru Nakayama, Takaharu Tanaka, Takaaki Kusumi, and Yoshikazu Tanaka An Isoflavone Conjugate-hydrolyzing β-Glucosidase from the Roots of Soybean (Glycine max) Seedlings: PURIFICATION, GENE CLONING, PHYLOGENETICS, AND CELLULAR LOCALIZATION The Journal of Biological Chemistry, 281 (2006) 30251-30259. Hirokazu Suzuki, Seiji Takahashi, Ryoko Watanabe, Yusuke Fukushima, Naoki Fujita, Akio Noguchi, Ryusuke Yokoyama, Kazuhiko Nishitani, Tokuzo Nishino, and Toru Nakayama Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases FEBS Journal, 273 (2006) 647-657. Yugesh Kharel, Seiji Takahashi, Satoshi Yamashita, and Tanetoshi Koyama The Regulatory Domain of SRK2E/OST1/SnRK2.6 Interacts with ABI1 and Integrates Abscisic Acid (ABA) and Osmotic Stress Signals Controlling Stomatal Closure in Arabidopsis. The Journal of Biological Chemistry, 281 (2006) 5310-5318. Riichiro Yoshida, Taishi Umezawa, Tsuyoshi Mizoguchi, Seiji Takahashi, Fuminori Takahashi, and Kazuo Shinozaki Structure and Function of cis-Prenyl Chain Elongating Enzymes The Chemical Record 6 (2006) 194-205. Seiji Takahashi, Tanetoshi Koyama Inositol and their metabolites in abiotic and biotic stress responses In Subcellular Biochemistry Volume 39: Biology of Inositols and Phosphoinositides (Edited by Lahiri Majumder, A. and Biswas, B.B) (2006) 239-264. Teruaki Taji, Seiji Takahashi and .Kazuo Shinozaki 天然ゴム生合成機構の解明と高生産系構築への展望 ”ファイバー”スーパーバイオミメティックス－新未来の新技術創成－ (株式会社エヌ・ティー・エス刊、本宮達也監修) (2006) pp.147-153 高橋征司、古山種俊 2005 UDP-Glucuronic Acid:Anthocyanin Glucuronosyltransferase from Red Daisy (Bellis perennis) Flowers:ENZYMOLOGY AND PHYLOGENETICS OF A NOVEL GLUCURONOSYLTRANSFERASE INVOLVED IN FLOWER PIGMENT BIOSYNTHESIS The Journal of Biological Chemistry, 280 (2005), 899-906. Shin'ya Sawada, Hirokazu Suzuki, Fumiko Ichimaida, Masa-atsu Yamaguchi, Takashi Iwashita, Yuko Fukui, Hisashi Hemmi, Tokuzo Nishino, and Toru Nakayama Microbacterium natoriense sp. nov., a novel D-aminoacylase-producing bacterium isolated from soil in Natori, Japan International Journal of Systematic and Evolutionary Microbiology，55 (2005), 661-665. Jian Liu, Toru Nakayama, Hisashi Hemmi, Yu Asano, Naoki Tsuruoka, Kengo Shimomura, Miyuki Nishijima　and Tokuzo Nishino Amperometric detection of the bacterial metabolic regulation with a microbial array chip Biosensors and Bioelectronics, 21 (2005) 145-151. Kuniaki Nagamine, Nobuto Matsui, Takatoshi Kaya, Tomoyuki Yasukawa, Hitoshi Shiku, Toru Nakayama, Tokuzo Nishino, Tomokazu Matsue Menaquinone-specific prenyl reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus Journal of Bacteriology, 187 (2005) 1937-1944. Hisashi Hemmi, Yoshihiro Takahashi, Kyohei Shibuya, Toru Nakayama, and Tokuzo Nishino Microbial Diversity in Bio-Degradation and Re-utilization Processes of Garbage JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 99 (2005) 1-11. SHIN HARUTA, TORU NAKAYAMA, KOHEI NAKAMURA, HISASHI HEMMI, MASAHARU ISHII, YASUO IGARASHI, AND TOKUZO NISHINO 植物アシル基転移酵素ファミリー生化学,　77（2005）343-347. 中山亨アントシアニングリコシル基転移酵素の進化と機能　特異性と普遍性化学と生物,　43 (2005) 142-145. 中山亨イソプレノイド生合成酵素の分子解析化学と生物, 43 (2005) 296-304. 高橋征司、古山種俊 2004 Cold-active esterase from Psychrobacter sp. Ant300: gene cloning, characterization, and the effects of Gly->Pro substitution near the active site on its catalytic activity and stability Biochimica et Biophysica Acta, 1696 (2004), 59-65 Ljudmila Kulakova, Andrey Galkin, Toru Nakayama, Tokuzo Nishino, Nobuyoshi Esaki cDNA cloning and characterization of two Dendranthema x morifolium anthocyanin malonyltransferases with different functional activities Plant Science, 166 (2004), 89-96. Hirokazu Suzuki, Toru Nakayama, Masa-atsu Yamaguchi, Tokuzo Nishino Molecular Biological Analysis of Microflora in a Garbage Treatment Process under Thermoacidophilic Conditions JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 97 (2004), 119-126. HISASHI HEMMI, TAKEFUMI SHIMOYAMA, TORU NAKAYAMA, KATSUJI HOSHI AND TOKUZO NISHINO cDNA cloning and functional characterization of flavonol 3-O-glucoside-6''-O-malonyltransferases from flowers of Verbena hybrida and Lamium purpureum Journal of Molecular Catalysis B: Enzymatic, 28 (2004), 87-93. Hirokazu Suzuki, Toru Nakayama, Shiro Nagae, Masa-atsu Yamaguchi, Takashi Iwashita, Yuko Fukui, Tokuzo Nishino Type 2 isopentenyl diphosphate isomerase from a thermoacidophilic archaeon Sulfolobus shibatae European Journal of Biochemistry, 271 (2004), 1087-1093. Satoshi Yamashita, Hisashi Hemmi, Yosuke Ikeda, Toru Nakayama and Tokuzo Nishino Crystallographic and Biochemical Investigations of Kumamolisin-As, a Serine-Carboxyl Peptidase with Collagenase Activity The Journal of Biological Chemistry, 279 (2004), 21500-21510. Alexander Wlodawer, Mi Li, Alla Gustchina, Naoki Tsuruoka, Masako Ashida, Hiroyuki Minakata, Hiroshi Oyama, Kohei Oda, Tokuzo Nishino, and Toru Nakayama Identification and characterization of a novel anthocyanin malonyltransferase from scarlet sage (Salvia splendens) flowers: an enzyme that is phylogenetically separated from other anthocyanin acyltransferases The Plant Journal, 38 (2004), 994-1003. Hirokazu Suzuki, Shin’ya Sawada, Kazufumi Watanabe, Shiro Nagae, Masa-atsu Yamaguchi, Toru Nakayama, and Tokuzo Nishino Catalytic mechanism of type 2 isopentenyl diphosphate: dimethylallyl diphosphate isomerase: verification of a redox role of the flavin cofactor in a reaction with no net redox change Biochemical and Biophysical Research Communications, 322 (2004), 905-910. Hisashi Hemmi, Yosuke Ikeda, Satoshi Yamashita, Toru Nakayama and Tokuzo Nishino Molecular Cloning and Characterization of a Thermostable Carboxylesterase from an Archaeon, Sulfolobus shibatae DSM5389: Non-Linear Kinetic Behavior of a Hormone-Sensitive Lipase Family Enzyme JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 98 (2004), 445-451. KOKI EJIMA, JIAN LIU, YASUHIRO OSHIMA, KAZUTAKE HIROOKA, SHOKO SHIMANUKI, YUKAKO YOKOTA, HISASHI HEMMI, TORU NAKAYAMA, AND TOKUZO NISHINO (S)-2,3-Di-O-geranylgeranylglyceryl Phosphate Synthase from the Thermoacidophilic Archaeon Sulfolobus solfataricus: Molecular Cloning and Characterization of a Membrane-intrinsic Prenyltransferase Involved in the Biosynthesis of Archaeal Ether-linked Membrane Lipids The Journal of Biological Chemistry, 279 (2004), 50197-50203. Hisashi Hemmi, Kyohei Shibuya, Yoshihiro Takahashi, Toru Nakayama, and Tokuzo Nishino 身近な酵素の新しい素顔　次々と明らかにされるポリフェノールオキシダーゼの新しい役割化学, 59 (2004), 55-56 中山亨 Monitoring the expression profiles of genes induced by hyperosmotic, high salinity, and oxidative stress and abscisic acid treatment in Arabidopsis cell culture using a full-length cDNA microarray Plant Molecular Biology, 56 (2004) 29-55. Seiji Takahashi, Motoaki Seki, Junko Ishida, Masakazu Satou, Tetsuya Sakurai, Mari Narusaka, Asako Kamiya, Maiko Nakajima, Akiko Enju, Kenji Akiyama, Kazuko Yamaguchi-Shinozaki, and Kazuo Shinozaki In vitro interaction between the human dehydrodolichyl diphosphate synthase and the Nieman-Pick C2 protein revealed by a yeast two-hybrid system Biochemical and Biophysical research Communications, 318 (2004) 198-203. Yugesh Kharel, Seiji Takahashi, Satoshi Yamashita, Tanetoshi Koyama 2003 Collagenolytic Serine-Carboxyl Proteinase from Alicyclobacillus sendaiensis Strain NTAP-1: Purification, Characterization, Gene Cloning, and Heterologous Expression APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 69 (2003), 162-169. Naoki Tsuruoka, Toru Nakayama, Masako Ashida, Hisashi Hemmi, Masahiro Nakao, Hiroyuki Minakata, Hiroshi Oyama, Kohei Oda, and Tokuzo Nishino Proposed Mechanism and Functional Amino Acid Residues of Malonyl-CoA:Anthocyanin 5-O-Glucoside-6''-O-Malonyltransferase from Flowers of Salvia Splendens, a Member of the Versatile Plant Acyltransferase Family Biochemistry, 42 (2003), 1764-1771. Hirokazu Suzuki, Toru Nakayama, and Tokuzo Nishino Alicyclobacillus sendaiensis sp. nov., a novel acidophilic, slightly thermophilic species isolated from soil in Sendai, Japan International Journal of Systematic and Evolutionary Microbiology, 53 (2003), 1081-1084. Naoki Tsuruoka, Yuri Isono, Osamu Shida, Hisashi Hemmi, Toru Nakayama, and Tokuzo Nishino Improvement of thermostability of cold-active serine alkaline protease from the psychrotrophic bacterium Shewanella sp. strain Ac10 by rational mutagenesis Journal of Molecular Catalysis B: Enzymatic, 22 (2003), 113-117. Ljudmila Kulakova, Andrey Galkin, Toru Nakayama, Tokuzo Nishino, Nobuyoshi Esaki Cloning, heterologous expression, renaturation, and characterization of a cold-adapted esterase with unique primary structure from a psychrotroph Pseudomonas sp. strain B11-1 Protein Expression and Purification, 30 (2003), 171-178. Takeshi Suzuki, Toru Nakayama, Dong Wong Choo, Yuriko Hirano, Tatsuo Kurihara, Tokuzo Nishino, and Nobuyoshi Esaki Fusion-type lycopene β-cyclase from a thermoacidophilic archaeon Sulfolobus solfataricus Biochemical and Biophysical Research Communications, 305 (2003), 586-591. Hisashi Hemmi, Satoru Ikejiri, Toru Nakayama, and Tokuzo Nishino Altering the substrate chain-length specificity of an α-glucosidase Biochemical and Biophysical Research Communications, 304 (2003), 684-690. Akio Noguchi, Toru Nakayama, Hisashi Hemmi, and Tokuzo Nishino An alternative mechanism of product chain-length determination in type III geranylgeranyl diphosphate synthase European Journal of Biochemistry, 270 (2003), 2186-2194. Hisashi Hemmi, Motoyoshi Noike, Toru Nakayama and Tokuzo Nishino Identification of a cDNA Encoding Malonyl-Coenzyme A:Anthocyanidin 3-O-Glucoside 6”-O-Malonyltransferase from Cineraria (Senecio cruentus) Flowers Plant Biotechnology, 20 (2003), 229-234. Hirokazu SUZUKI, Shin-ya SAWADA, Keiko YONEKURA-SAKAKIBARA, Toru NAKAYAMA, Masa-atsu YAMAGUCHI, and Tokuzo NISHINO Deciphering the Molecular Basis of the Broad Substrate Specificity of α-Glucosidase from Bacillus sp. SAM1606 Journal of Biochemistry, 134 (2003), 543-550. Akio Noguchi, Masayasu Yano, Yasuhiro Ohshima, Hisashi Hemmi, Misa Inohara-Ochiai, Maki Okada, Kyong-Son Min, Toru Nakayama and Tokuzo Nishino Acidulocomposting, an Accelerated Composting Process of Garbage under Thermoacidophilic Conditions for Prolonged Periods Journal of Environmental Biotechnology (環境バイオテクノロジー学会誌), 3 (2003), 33-36. TOKUZO NISHINO, TORU NAKAYAMA, HISASHI HEMMI, TAKEFUMI SHIMOYAMA, SATOSHI YAMASHITA, MINORU AKAI, TAKAHIRO KANAGAWA and KATSUJI HOSHI 花色発現をつかさどるポリフェノールオキシダーゼの酵素科学日本農芸化学会誌 77, (2003), 421-424. 中山亨 Anthocyanin acyltransferases: specificities, mechanism, phylogenetics, and applications Journal of Molecular Catalysis B: Enzymatic, 23 (2003), 117-132. Toru Nakayama, Hirokazu Suzuki, Tokuzo Nishino Molecular Cloning, Expression and Characterization of cDNA Encoding cis-Prenyltransferases from Hevea brasiliensis - A key factor participating in natural rubber biosynthesis European Journal of Biochemistry, 270 (2003) 4671-4680. Kasem Asawatreratanakul, Yuan-Wei Zhang, Dhirayos Wititsuwannakul, Rapepun Wititsuwannakul, Seiji Takahashi, Atiya Rattanapittayaporn, Tanetoshi Koyama Isolation and expression of Paracoccus denitrificans decaprenyl diphosphate synthase gene for production of ubiquinone-10 in Escherichia coli Biochemical Engineering Journal, 16 (2003) 183-190. Seiji Takahashi, Tokuzo Nishino, Tanetoshi Koyama Identification of human dehydrodolichyl diphosphate synthase gene Biochimica et Biophysica Acta, 1625 (2003) 291-295. Shota Endo, Yuan-Wei Zhang, Seiji Takahashi, Tanetoshi Koyama Cloning, expression and characterization of a functional cDNA clone encoding geranylgeranyl diphosphate synthase of Hevea brasiliensis Biochimica et Biophysica Acta, 1625 (2003) 214-220. Akiyuki Takaya, Yuan-Wei Zhang, Kasem Asawatreratanakul, Dhirayos Wititsuwannakul, Rapepun Wititsuwannakul, Seiji Takahashi, Tanetoshi Koyama プレニル鎖延長酵素の遺伝子解明研究からみた天然ゴム生合成の分子解析日本ゴム協会誌, 76（2003）446-452 高橋征司、古山種俊 2002 cDNA Cloning, Heterologous Expressions, and Functional Characterization of Malonyl-CoA:Anthocyanidin 3-O-Glucoside-6"-O-Malonyltransferase from Dahlia variabilis Flowers Plant Physiology, 130 (2002), 2142-2151. Hirokazu Suzuki, Toru Nakayama, Keiko Yonekura-Sakakibara, Yuko Fukui, Noriko Nakamura, Masa-atsu Yamaguchi, Yoshikazu Tanaka, Takaaki Kusumi, and Tokuzo Nishino Site-specific mutagenesis at positions 272 and 273 of the Bacillus sp. SAM1606 α-glucosidase to screen mutants with altered specificity for oligosaccharide production by transglucosylation Journal of Molecular Catalysis B: Enzymatic, 16 (2002), 265-274. Maki Okada, Toru Nakayama, Akio Noguchi, Masayasu Yano, Hisashi Hemmi, Tokuzo Nishino, Takashi Ueda A cold-active esterase with a substrate preference for vinyl esters from a psychrotroph, Acinetobacter sp. strain No.6: gene cloning, purification, and characterization Journal of Molecular Catalysis B: Enzymatic, 16 (2002), 255-263. Takeshi Suzuki, Toru Nakayama, Tatsuo Kurihara, Tokuzo Nishino, Nobuyoshi Esaki Primary Structure and Catalytic Properties of a Cold-active Esterase from a Psychrotroph, Acinetobacter sp. Strain No.6 Isolated from Siberian Soil Bioscience, Biotechnology, and Biochemistry, 66 (2002), 1682-1690. Takeshi SUZUKI, Toru NAKAYAMA, Tatsuo KURIHARA, Tokuzo NISHINO, and Nobuyoshi ESAKI Deletion and Insertion of a 192-Residue Peptide in the Active-Site Domain of Glycosyl Hydrolase Family-2 β-Galactosidases JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 93 (2002), 575-583. MISA INOHARA-OCHIAI, SATOSHI HASEGAWA, SOTA IGUCHI, TOSHIHIKO ASHIKARI, YUJI SHIBANO, HISASHI HEMMI, TORU NAKAYAMA, AND TOKUZO NISHINO Novel Sugar Phosphotransferase System Applicable to the Efficient Labeling of the Compounds Synthesized via the Non-Mevalonate Pathway in Escherichia coli JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 93 (2002), 515-518. HISASHI HEMMI, SATOSHI YAMASHITA, TORU NAKAYAMA, AND TOKUZO NISHINO Hsc62, Hsc56, and GrpE, the third Hsp70 chaperone system of Escherichia coli Biochemical and Biophysical Research Communications, 293 (2002), 1389-1385. Kazuaki Yoshimune, Tohru Yoshimura, Toru Nakayama, Tokuzo Nishino, and Nobuyoshi Esaki Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations Biochemical and Biophysical Research Communications, 297 (2002), 1096-1101. Hisashi Hemmi, Motoyoshi Noike, Toru Nakayama, and Tokuzo Nishino Synthesis of Glucosyltrehaloses by a Thermostable α-Glucosidase with Broad Substrate Specificity and High Transglucosylation Activity: Assessment Using Wild-Type Enzyme and Mutants with Amino Acid Substitution near Active Site Journal of Japanese Society of Nutrition and Food Science, 55 (2002), 19-25. Maki Okada, Toru Nakayama, Akio Noguchi, Tokuzo Nishino, Yukiko Kan, Takashi Iwashita, and Takashi Ueda 生体触媒の新しい機能・特性の探索と解析生物工学会誌, 80 (2002), 111-117. 中山亨 Enzymology of Aurone Biosynthesis JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 94 (2002), 487-491. TORU NAKAYAMA 2001 Malonyl-CoA:Anthocyanin 5-O-Glucoside-6'''-O-Malonyltransferase from Scarlet Sage (Salvia splendens) Flowers ENZYME PURIFICATION, GENE CLONING, EXPRESSION, AND CHARACTERIZATION The Journal of Biological Chemistry, 276 (2001), 49013-49019. Hirokazu Suzuki, Toru Nakayama, Keiko Yonekura-Sakakibara, Yuko Fukui, Noriko Nakamura, Masahiro Nakao,　Yoshikazu Tanaka, Masa-atsu Yamaguchi, Takaaki Kusumi, and Tokuzo Nishino Cloning, Expression, and Characterization of cis-Polyprenyl Diphosphate Synthase from the Thermoacidophilic Archaeon Sulfolobus acidocaldarius JOURNAL OF BACTERIOLOGY, 183 (2001), 401-404. HISASHI HEMMI, SATOSHI YAMASHITA, TAKEFUMI SHIMOYAMA, TORU NAKAYAMA, AND TOKUZO NISHINO Enzymatic formation of aurones in the extracts of yellow snapdragon flowers Plant Science, 160 (2001), 229-236. Takuya Sato, Toru Nakayama, Sanae Kikuchi, Yuko Fukui, Keiko Yonekura-Sakakibara, Takashi Ueda, Tokuzo Nishino, Yoshikazu Tanaka, Takaaki Kusumi Cloning and rational mutagenesis of kexstatin I, a potent proteinaceous inhibitor of Kex2 proteinase Biochemical Journal, 355 (2001), 339-346. Kohei ODA, Hiroshi OYAMA, Satoshi ITO, Momoko FUKIHARU, Yu MIYAGAWA, Saori TAKAHASHI, Mika HIROSE, Norihisa KIKUCHI, Toru NAKAYAMA and Yuji SHIBANO Specificity analysis and mechanism of aurone synthesis catalyzed by aureusidin synthase, a polyphenol oxidase homolog responsible for flower coloration FEBS Letters, 499 (2001), 107-111. Toru Nakayama, Takuya Sato, Yuko Fukui, Keiko Yonekura-Sakakibara, Hideyuki Hayashi, Yoshikazu Tanaka, Takaaki Kusumi, Tokuzo Nishino Cold-Active Lipolytic Activity of Psychrotrophic Acinetobacter sp. Strain No. 6 JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 92 (2001), 144-148. TAKESHI SUZUKI, TORU NAKAYAMA, TATSUO KURIHARA, TOKUZO NISHINO, AND NOBUYOSHI ESAKI 生ごみのアシドロコンポスト化と酵素による支援バイオサイエンスとインダストリー, 59 (2001), 98-101. 中山亨　西野徳三アシドロコンポスト化：臭気発生のほとんどない新しいコンポスト化プロセス臭気の研究, 32 (2001), 210-216. 中山亨　西野徳三「黄色い」花を作る第一歩　明らかになったオーロン生合成経路と植物ポリフェノールオキシダーゼの新しい役割化学と生物, 39 (2001), 564-565．中山亨，田中良和 An essential role of a TatC homologue of a pH-dependent protein transporter in thylakoid membrane formation during chloroplast development in Arabidopsis thaliana Proceedings of the National Academy of Sciences of the United States of America, 98 (2001) 10499-10504. Reiko Motohashi, Noriko Nagata, Takuya Ito, Seiji Takahashi, Tokunori Hobo,　Shigeo Yoshida, and Kazuo Shinozaki Involvement of a novel Arabidopsis phospholipase D, AtPLD, in dehydration-inducible accumulation of phosphatidic acid in stress signaling The Plant Journal, 26 (2001) 595-605. Takeshi Katagiri, Seiji Takahashi, and Kazuo Shinozaki Hyperosmotic stress induces a rapid and transient increase in inositol 1,4,5-trisphosphate independent of abscisic acid in Arabidopsis cell culture Plant and Cell Physiology, 42 (2001) 214-222. Seiji Takahashi, Takeshi Katagiri, Takashi Hirayama, Kazuko Yamaguchi-Shinozaki and Kazuo Shinozaki 2000 Aureusidin Synthase: A Polyphenol Oxidase Homolog Responsible for Flower Coloration Science, 290 (2000), 1163-1166. T. Nakayama, K. Yonekura-Sakakibara, T. Sato, S. Kikuchi, Y. Fukui, M. Fukuchi-Mizutani, T. Ueda, M. Nakao, Y. Tanaka, T. Kusumi, T. Nishino Purification and inactivation by substrate of an allene oxide synthase (CYP74) from corn (Zea mays L.) seeds Phytochemistry, 53 (2000), 319-323. Yukiko Utsunomiya, Toru Nakayama, Hideo Oohira, Rie Hirota, Terutoshi Mori, Fusako Kawai, Takashi Ueda HPLC Analysis and Optimization of Enzymatic Synthesis of 4'-O-(β-D-Glucopyranosyl)-D-Pantothenic Acid Journal of Nutritional Science and Vitaminology, 46 (2000), 101-104. Maki OKADA, Miho KYOGUCHI, Toru NAKAYAMA, Rie HIROTA, Teruo AMACHI and Takashi UEDA Thermostable Collagenolytic Activity of a Novel Thermophilic Isolate, Bacillus sp. Strain NTAP-1 JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 89 (2000), 612-614. TORU NAKAYAMA, NAOKI TSURUOKA, MINORU AKAI, AND TOKUZO NISHINO Zinc biosorption by a zinc-resistant bacterium, Brevibacterium sp. strain HZM-1 Applied Microbiology and Biotechnology, 54 (2000), 581-588. J. Taniguchi ・ H. Hemmi ・ K. Tanahashi ・ N. Amano ・ T. Nakayama ・ T. Nishino An Active-Site Mutation Causes Enhanced Reactivity and Altered Regiospecificity of Transglucosylation Catalyzed by the Bacillus sp. SAM1606 α-Glucosidase JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 89 (2000), 431-437. MISA INOHARA-OCHIAI, MAKI OKADA, TORU NAKAYAMA, HISASHI HEMMI, TAKASHI UEDA, TAKASHI IWASHITA, YUKIKO KAN, YUJI SHIBANO, TOSHIHIKO ASHIKARI, AND TOKUZO NISHINO Mutational Analysis of the Role of His452 of Saccharopolyspora rectivirgula β-Galactosidase JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 90 (2000), 535-539. TORU NAKAYAMA, YUKA GOTO, SATOSHI HASEGAWA, MISA INOHARA-OCHIAI, YUJI SHIBANO, TOSHIHIKO ASHIKARI, AND TOKUZO NISHINO Molecular and functional characterization of a rose lipoxygenase cDNA related to flower senescence Plant Science, 160 (2000), 129-137. Masako Fukuchi-Mizutani, Kanako Ishiguro, Toru Nakayama, Yukiko Utsunomiya, Yoshikazu Tanaka, Takaaki Kusumi, Takashi Ueda An Arabidopsis gene encoding a Ca2+-binding protein is induced by abscisic acid during dehydration Plant and Cell Physiology, 41 (2000) 898-903. Seiji Takahashi, Takeshi Katagiri, Kazuko Yamaguchi-Shinozaki and Kazuo Shinozaki 1999 Purification, characterization, and application of an acid urease from Arthrobacter mobilis Journal of Biotechnology, 68 (1999), 227-236. Katsuro Miyagawa, Motoo Sumida, Masahiro Nakao, Masami Harada, Hiroshi Yamamoto, Takaaki Kusumi, Kiyoshi Yoshizawa, Teruo Amachi, Toru Nakayama Fungal peroxidase: its structure, function, and application Journal of Molecular Catalysis B: Enzymatic, 6 (1999), 185-198. Toru Nakayama, Teruo Amachi 微生物β-ガラクトシダーゼの分子酵素学とその応用 TOBIN, No. 18 (1999), 37-41. 中山亨 Isolation of an Arabidopsis thaliana cDNA encoding a pleckstrin homology domain protein, a putative homologue of human plackstrin Journal of Experimental Botany, 50 (1999) 729-730. Koji Mikami, Seiji Takahashi, Takeshi Katagiri, Kazuko Yamaguchi-Shinozaki and Kazuo Shinozaki 1998 Unique primary structure of a thermostable multimetal β-galactosidase from Saccharopolyspora rectivirgula Biochimica et Biophysica Acta, 1388 (1998), 77-83. Misa Inohara-Ochiai, Toru Nakayama, Masahiro Nakao, Tsuyoshi Fujita, Takashi Ueda, Toshihiko Ashikari, Tokuzo Nishino, Yuji Shibano 広範な基質特異性を有するα-グルコシダーゼとそのトレハロース認識に関わるアミノ酸残基応用糖質科学 (Oyo Toshitsu Kagaku: J. Appl. Glycosci.), 45 (1998), 185-197. 中山亨，落合美佐，中尾正宏，後藤理枝子，上田隆史，柴野裕次 1997 Altering Substrate Specificity of Bacillus sp. SAM1606 α-Glucosidase by Comparative Site-specific Mutagenesis The Journal of Biological Chemistry, 272 (1997), 1601-1607. Misa Inohara-Ochiai, Toru Nakayama, Rieko Goto, Masahiro Nakao, Takashi Ueda, and Yuji Shibano 微生物β-ガラクトシダーゼ：その酵素学と食品工学的利用 New Food Industry, 39 (1997), 58-64. 中山亨　上田隆史 1996 好熱性放線菌Saccharopolyspora rectivirgula の耐熱性マルチメタルβ-ガラクトシダーゼの機能と構造応用糖質科学 (Oyo Toshitsu Kagaku: J. Appl. Glycosci.), 43 (1996), 237-245. 中山亨, 落合美佐, 中尾正宏, 原田雅己, 上田隆史, 柴野裕次 β-ガラクトシダーゼ研究の進展生物工学会誌, 74 (1996), 135. 中山亨 1995 Visible Light-Sensitized Oxidation of Arachidonic Acid in the Presence of Inperatorin Journal of Nutritional Science and Vitaminology, 41 (1995), 387-393. Yuka FUKUI, Mayumi MORITA, Kazuko OSAKADA, Toru NAKAYAMA, Masakazu MATSUOKA, Rie HIROTA, Hisako IIZUMI, and Takashi UEDA Visible Spectrophotometric Assay, Purification, and Molecular Properties of a Lipoxygenase from Eggplant (Solanum melongena Linne) Fruits BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 214 (1995), 1067-1072. Toru Nakayama, Yuriko Takeura, and Takashi Ueda Structures of genomic and complementary DNAs coding for Pleurotus ostreatus manganese (II) peroxidase Biochimica et Biophysica Acta, 1251 (1995), 205-209. Yasuhiko Asada, Akira Watanabe, Toshikazu Irie, Toru Nakayama, Masaaki Kuwahara Cloning, Sequencing, and Heterologous Expression of a Gene Coding for Arthromyces ramosus Peroxidase Bioscience, Biotechnology, and Biochemistry, 59 (1995), 1221-1228. Haruyo SAWAI-HATANAKA, Toshihiko ASHIKARI, Yoshikazu TANAKA, Yasuhiko ASADA, Toru NAKAYAMA, Hiroyuki MINAKATA, Naoki KUNISHIMA, Keiichi FUKUYAMA, Hideaki YAMADA, Yuji SHIBANO, and Teruo AMACHI 1994 Purification and characterization of a thermostable β-galactosidase with high transgalactosylation activity from Saccharopolyspora rectivirgula Applied Microbiology and Biotechnology, 40 (1994), 657-663. Masahiro Nakao, Masami Harada, Yukiko Kodama, Toru Nakayama, Yuji Shibano, Teruo Amachi Purification and characterization of a Bacillus sp. SAM1606 thermostable α-glucosidase with high transglucosylation activity Applied Microbiology and Biotechnology, 40 (1994), 337-343. M. Nakao ・ T. Nakayama ・ M. Harada ・ A. Kakudo ・ H. Ikemoto ・ S. Kobayashi ・ Y. Shibano Structure and expression of a gene coding for thermostable α-glucosidase with a broad substrate specificity from Bacillus sp. SAM1606 European Journal of Biochemistry, 220 (1994), 293-300. Masahiro NAKAO, Toru NAKAYAMA, Akemi KAKUDO, Misa INOHARA, Masami HARADA, Fumihiko OMURA, and Yuji SHIBANO Oxidation-Reduction Properties of Compounds I and II of Arthromyces ramosus Peroxidase Biochemistry, 33 (1994), 5647-5652. Z. Shadi Farhangrazi, Bruce R. Copeland, Toru Nakayama, Teruo Amachi, Isao Yamazaki, and L. S. Powers Divalent Metal Ion Requirements of a Thermostable Multimetal β-Galactosidase from Saccharopolyspora rectivirgula The Journal of Biological Chemistry, 269 (1994), 22021-22026. Masami Harada, Misa Inohara, Masahiro Nakao, Toru Nakayama, Akemi Kakudo, Yuji Shibano, and Teruo Amachi 1983-1993 Purification and Characterization of Endogeneous Protein Activator of Human Platelet Proteasome Journal of Biochemistry, 114 (1993), 317-323. Masao Yukawa, Masato Sakon, Jun-ichi Kambayashi, Ei-ichi Shiba, Tomio Kawasaki, Yoshio Uemura, Kohei Murata, Takaharu Tanaka, Toru Nakayama, Hiroshi Shibata, and Takesada Mori 目で見るバイオ　微生物ペルオキシダーゼと化学発光バイオサイエンスとバイオインダストリー, 50 (1992), 7-8. 中山亨・天知輝夫微生物ペルオキシダーゼの性質とその応用バイオサイエンスとインダストリー, 50 (1992), 442-444. 中山亨・天知輝夫 A Novel Trehalase Inhibitor, Trehalostatin, Produced by Amycolatopsis trehalostatica HG-25 Agricultural and Biological Chemistry, 55 (1991), 895-897. Sawao MURAO, Takafumi SAKAI, Hideki GIBO, Toru NAKAYAMA and Takashi SHIN Structure of Trehalostatin: A Potent and Specific Inhibitor of Trehalase Journal of Chemical Society Chemical Communications, Issue 14 (1991), 919-921. Toru Nakayama, Teruo Amachi, Sawao Murao, Takafumi Sakai, Takashi Shin, Peter T. M. Kenny, Takashi Iwashita, Michael Zagorski, Hajime Komura and Kyosuke Nomoto トレハロース，トレハラーゼ，トレハラーゼ阻害剤醗酵工学, 69 (1991), 273-247. 中山亨 Specific Labeling of the Essential Cysteine Residue of L-Methionine γ-Lyase with a Cofactor Analogue, N-(Bromoacetyl)pyridoxamine Phosphate Biochemistry, 27 (1988), 1587-1591. Toru Nakayama, Nobuyoshi Esaki, Hidehiko Tanaka, and Kenji Soda Chemical Modification of Cysteine Residues of L-Methionine γ-Lyase Agricultural and Biological Chemistry, 52 (1988), 177-183. Toru NAKAYAMA, Nobuyoshi ESAKI, Hidehiko TANAKA and Kenji SODA Catalytic Action of L-Methionine γ-Lyase on 4-Azaleucine Agricultural and Biological Chemistry, 51 (1987), 3159-3160. Setsuo FURUYOSHI, Toru NAKAYAMA, Nobuyoshi ESAKI, Hidehiko TANAKA and Kenji SODA Synthesis of Labeled (±)-2-Amino-3-butenoic Acids Journal of Organic Chemistry, 51 (1986), 3384-3386. Seiji Sawada, Thoru Nakayama, Nobuyoshi Esaki, Hidehiko Tanaka, Kenji Soda, and Richard K. Hill L-Methionine gγ-lyaseの酵素自殺基質反応：S-(N-methylthio carbamoyl)-L-cysteineによる不活性化とその機構含硫アミノ酸 (Sulfur Amino Acids), 9 (1986), 281-283. 江崎信芳, 木村富美夫, 後藤譲治, 中山亨, 田中英彦, 左右田健次 1H NMR Studies of Substrate Hydrogen Exchange Reactions Catalyzed by L-Methionine γ-Lyase Biochemistry, 24 (1985), 3857-3862. Nobuyoshi Esaki, Toru Nakayama, Seiji Sawada, Hidehiko Tanaka, and Kenji Soda Purification of Bacterial L-Methionine γ-Lyase ANALYTICAL BIOCHEMISTRY, 138 (1984), 421-424. TORU NAKAYAMA, NOBUYOSHI ESAKI, KUNIO SUGIE, TEMIR T. BERESOV, HIDEHIKO TANAKA, AND KENJI SODA S-(N-METHYLTHIOCARBAMOYL)-L-CYSTEINE, A SUICIDE SUBSTRATE OF L-METHIONINE γ-LYASE Biochimica et Biophysica Acta, 785 (1984), 54-60. NOBUYOSHI ESAKI, TOMIO KIMURA, JOJI GOTO, TORU NAKAYAMA, HIDEHIKO TANAKA and KENJI SODA Reactions of O-Substituted L-Homoserines Catalyzed by L-Methionine γ-Lyase and Their Mechanism Agricultural and Biological Chemistry, 48 (1984), 1991-1996. Nobuyoshi ESAKI, Toru NAKAYAMA, Seiji SAWADA, Hidehiko TANAKA and Kenji SODA Purification and Properties of L-Methionine g-Lyase from Aeromonas sp. Agricultural and Biological Chemistry, 48 (1984), 2367-2369. Toru NAKAYAMA, Nobuyoshi ESAKI, Woon-Joo LEE, Izumi TANAKA, Hidehiko TANAKA and Kenji SODA 光学活性含セレンアミノ酸の合成含硫アミノ酸 (Sulfur Amino Acids), 7 (1984), 221-224. PATRIC CHOCAT, 中山亨, 江崎信芳, 田中英彦, 左右田健次 L-Methionine γ-Lyase: 精製方法の改良とサブユニット構造含硫アミノ酸 (Sulfur Amino Acids), 6 (1983), 175-178. 中山亨, 江崎信芳, 与那覇和雄, 田中英彦, 左右田健次
Eiichiro Ono, Yu Homma, Manabu Horikawa, Satoshi Kunikane-Doi, Haruna Imai, Seiji Takahashi, Yosuke Kawai, Masaji Ishiguro, Yuko Fukui, and Toru Nakayama
?	*Functional Differentiation of the Glycosyltransferases That Contribute to the Chemical Diversity of Bioactive Flavonol Glycosides in Grapevines (Vitis vinifera)*
?	Plant Cell First published on August 6, 2010;
2009 New role of flavin as a general acid-base catalyst with no dedox function in type 2 isopentenyl-diphosphate isomerase The Journal of Biological Chemistry 284 (2009)　9160-9167 Hideaki Unno, Satoshi Yamashita, Yosuke Ikeda, Shin-ya Sekiguchi, Norie Yoshida, Tohru Yoshimura, Masami Kusunoki, Toru Nakayama, Tokuzo Nishino, Hisashi Hemmi Effect of mutagenesis at the region upstream from the G(Q/E) motif of three types of geranylgeranyl diphosphate synthase on product chain-length Journal of Bioscience and Bioengineering 107 (2009) 235-239 Motoyoshi Noike, Takashi Katagiri, Toru Nakayama, Tokuzo Nishino, Hisashi Hemmi Polymerase chain reaction-denaturing gradient gel electrophoresis analysis of microbial community structure in landoll leachate J. Hazard. Mater. 164 (2009) 1503-1508 Miho Uchida, Haruna Hatayoshi, Aoi Syuku-nobe, Takefumi Shimoyama, Toru Nakayama, Akitsugu Okuwaki, Tokuzo Nishino, Hisashi Hemmi Local differentiation of sugar donor speciocity of flavonoid glycosyltransferase in Lamiales Plant Cell 21 (2009) 1556-1572 Akio Noguchi, Manabu Horikawa, Yuko Fukui, Masako Fukuchi-Mizutani, Asako Iuchi-Okada, Masaji Ishiguro, Yoshinobu Kiso, Toru Nakayama, Eiichiro Ono Identification of an inducible glucosyltransferase from Phytolacca americana L. cells that are capable of glucosylating capsaicin Plant Biotechnol. 26 (2009) 285-292 Akio Nogichi, Satoshi Kunikane, Hiroaki Homma, Wenhai Liu, Takashi Sekiya, Miho Hosoya, Soonil Kwon, Shingo Ohiwa, Hisashi Katsuragi, Tokuzo Nishino, Seiji Takahashi, Hiroaki Hamada, Toru Nakayama Kinetic and thermodynamic characterization of the cold activity acquired upon single amino-acid substitution near the active site of a thermostable α-glucosidase Journal of Molecular Catalysis B: Enzymatic 56 (2009) 300-306 Akio Noguchi, Tokuzo Nishino, Toru Nakayama マメ科植物におけるイソフラボンの修飾 . 脱修飾を介した代謝調節：単離が進む関連酵素遺伝子群とその機能解明化学と生物 47 (2009) 160-162 高橋征司，中山　亨 2008 A novel glucosylation enzyme: molecular cloning, expression, and characterization of Trichoderma viride JCM22452 alpha-Amylase and enzymatic synthesis of some flavonoid monoglucosides and oligoglucosides J. Agric. Food Chem. 56 (2008) 12016-12024 Noguchi A., Inohara-Ochiai M., Ishibashi N., Fukami H., Nakayama T., Nakao M. 花色調節技術への期待：アントシアニンアシル基転移酵素の機能と構造. 生物工学会誌 86(2008)171-173 中山　亨 The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction The FEBS Journal 275 (2008) 3921-3933 Motoyoshi Noike, Takashi Katagiri, Toru Nakayama, Tanetoshi Koyama, Tokuzo Nishino and Hisashi Hemmi cDNA cloning of glycosyltransferases from Chinese wolfberry (Lycium barbarum L.) fruits and enzymatic synthesis of a catechin glucoside using a recombinant enzyme (UGT73A10) Journal of Molecular Catalysis B: Enzymatic 55 (2008) 84-92 Akio Noguchi, Nobuhiro Sasaki, Masahiro Nakaoa, Harukazu Fukami, Seiji Takahashi, Tokuzo Nishino, Toru Nakayama 好熱性コラーゲン分解酵素生産菌 Thermobifida sp. 4-2-1 株の分離とキャラクタリゼーション環境バイオテクノロジー学会誌 80 (2008) 99-103 大野正博，山口晴彦，高橋征司，中山　亨植物二次代謝産物グリコシルトランスフェラーゼの構造と機能生化学 80 (2008) 1033-1038 國兼　聡，中山　亨植物二次代謝産物グリコシルトランスフェラーゼによる脂溶性有用物質のグリコシル化生物工学 86 (2008) 4 中山　亨黄色フラボノイド色素，オーロンによる黄色花の分子育種化学と生物 46 (2008) 62-69 小埜栄一郎，福井祐子，中山　亨 2007 A UDP-glucose:isoflavone 7-O-glucosyltransferase from the roots of soybean (Glycine max) seedlings:? PURIFICATION, GENECLONING, PHYLOGENETICS, AND AN IMPLICASTION FOR AN ALTERNATIVE STRATEGY OF ENZYME CATALYSIS The Journal of Biological Chemistry 282 (2007)　23581-23590 Akio Noguchi, Atsushi Saito, Yu Homma, Masahiro Nakao, Nobuhiro Sasaki, Tokuzo Nishino, Seiji Takahashi, and Toru Nakayama cDNA cloning of a BAHD acyltransferase from soybean (Glycine max): Isoflavone 7-O-glucoside-6’-O-malonyltransferase Phytochemistry 68 (2007) 2035-2042 Hirokazu Suzuki, Tokuzo Nishino, Toru Nakayama Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermiphilic archaeon Archaeoglobus fulgidus The FEBS Journal 274 (2007) 805-814 Motomichi Murakami, Kyohei Shibuya, Toru Nakayama, Tokuzo Nishino, Tohru Yoshimura and Hisashi Hemmi Structural and Mutational Studies of Anthocyanin Malonyltransferases Establish the Features of BAHD Enzyme Catalysis The Journal of Biological Chemistry　282 (2007) 15812-15822 Hideaki Unno, Fumiko Ichimaida, Hirokazu Suzuki, Seiji Takahashi, Yoshikazu Tanaka, Atsushi Saito, Tokuzo Nishino, Masami Kusunoki, and Toru Nakayama The QM/MM Molecular Dynamics and Free Energy Simulations of the Acylation Reaction Catalyzed by the Serine-Carboxyl Peptidase Kumamolisin-As. Biochemistry 46 (2007) 3784-3792 Qin Xu, Hao-Bo Guo, Alexander Wlodawer, Toru Nakayama, and Hong Guo Anthocyanin acyltransferase engineered for the synthesis of a novel polyacylated anthocyanin Plant Biotechnology 24 (2007) 495-501 Hirokazu Suzuki, Tokuzo Nishino, Toru Nakayama Molecular Breeding of Novel Yellow Flowers by Engineering the Aurone Biosynthetic Pathway Transgenic Plant Journal 1 (2007) 66-80 Eiichiro Ono, Toru Nakayama 植物フラボノイド，オーロンによる黄色花の分子育種ブレインテクノニュース 119 (2007) 19-25 小埜栄一郎，中山　亨 Classical なアプローチバイオサイエンスとインダストリー 65 (2007) 33 中山　亨 2006 Localization of a flavonoid biosynthetic polyphenol oxidase in vacuoles The Plant Journal, 45 (2006) 133-143. Eiichiro Ono, Masayoshi Hatayama, Yuri Isono, Takuya Sato, Ryoko Watanabe, Keiko Yonekura-Sakakibara, Masako Fukuchi-Mizutani, Yoshikazu Tanaka, Takaaki Kusumi, Tokuzo Nishino and Toru Nakayama Biochemical characterrization and mutational studies of a chalcone synthase from yellow snapdragon (Antirrhinum majus) flowers Plant Biotechnology, 23 (2006) 373-378. Masayoshi Hatayama, Eiichiro Ono, Keiko Yonekura-Sakakibara, Yoshikazu Tanaka, Tokuzo Nishino, Toru Nakayama Catalytic Role of Proton Transfers in the Formation of a Tetrahedral Adduct in a Serine Carboxyl Peptidase Biochemistry, 45 (2006) 9129-9137. Haobo Guo, Alexander Wlodawer, Toru Nakayama, Qin Xu, and Hong Guo Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site The FEBS Journal, 273, (2006) 2563-2576. Ayumi Okubo, Mi Li, Masako Ashida, Hiroshi Oyama, Alla Gustchina, Kohei Oda, Ben M. Dunn, Alexander Wlodawer and Toru Nakayama Yellow flowers generated by expression of the aurone biosynthetic pathway Proceedings of the National Academy of Sciences of the United States of America, 103 (2006) 11075-11080. Eiichiro Ono, Masako Fukuchi-Mizutani, Noriko Nakamura, Yuko Fukui, Keiko Yonekura-Sakakibara, Masaatsu Yamaguchi, Toru Nakayama, Takaharu Tanaka, Takaaki Kusumi, and Yoshikazu Tanaka An Isoflavone Conjugate-hydrolyzing β-Glucosidase from the Roots of Soybean (Glycine max) Seedlings: PURIFICATION, GENE CLONING, PHYLOGENETICS, AND CELLULAR LOCALIZATION The Journal of Biological Chemistry, 281 (2006) 30251-30259. Hirokazu Suzuki, Seiji Takahashi, Ryoko Watanabe, Yusuke Fukushima, Naoki Fujita, Akio Noguchi, Ryusuke Yokoyama, Kazuhiko Nishitani, Tokuzo Nishino, and Toru Nakayama Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases FEBS Journal, 273 (2006) 647-657. Yugesh Kharel, Seiji Takahashi, Satoshi Yamashita, and Tanetoshi Koyama The Regulatory Domain of SRK2E/OST1/SnRK2.6 Interacts with ABI1 and Integrates Abscisic Acid (ABA) and Osmotic Stress Signals Controlling Stomatal Closure in Arabidopsis. The Journal of Biological Chemistry, 281 (2006) 5310-5318. Riichiro Yoshida, Taishi Umezawa, Tsuyoshi Mizoguchi, Seiji Takahashi, Fuminori Takahashi, and Kazuo Shinozaki Structure and Function of cis-Prenyl Chain Elongating Enzymes The Chemical Record 6 (2006) 194-205. Seiji Takahashi, Tanetoshi Koyama Inositol and their metabolites in abiotic and biotic stress responses In Subcellular Biochemistry Volume 39: Biology of Inositols and Phosphoinositides (Edited by Lahiri Majumder, A. and Biswas, B.B) (2006) 239-264. Teruaki Taji, Seiji Takahashi and .Kazuo Shinozaki 天然ゴム生合成機構の解明と高生産系構築への展望 ”ファイバー”スーパーバイオミメティックス－新未来の新技術創成－ (株式会社エヌ・ティー・エス刊、本宮達也監修) (2006) pp.147-153 高橋征司、古山種俊 2005 UDP-Glucuronic Acid:Anthocyanin Glucuronosyltransferase from Red Daisy (Bellis perennis) Flowers:ENZYMOLOGY AND PHYLOGENETICS OF A NOVEL GLUCURONOSYLTRANSFERASE INVOLVED IN FLOWER PIGMENT BIOSYNTHESIS The Journal of Biological Chemistry, 280 (2005), 899-906. Shin'ya Sawada, Hirokazu Suzuki, Fumiko Ichimaida, Masa-atsu Yamaguchi, Takashi Iwashita, Yuko Fukui, Hisashi Hemmi, Tokuzo Nishino, and Toru Nakayama Microbacterium natoriense sp. nov., a novel D-aminoacylase-producing bacterium isolated from soil in Natori, Japan International Journal of Systematic and Evolutionary Microbiology，55 (2005), 661-665. Jian Liu, Toru Nakayama, Hisashi Hemmi, Yu Asano, Naoki Tsuruoka, Kengo Shimomura, Miyuki Nishijima　and Tokuzo Nishino Amperometric detection of the bacterial metabolic regulation with a microbial array chip Biosensors and Bioelectronics, 21 (2005) 145-151. Kuniaki Nagamine, Nobuto Matsui, Takatoshi Kaya, Tomoyuki Yasukawa, Hitoshi Shiku, Toru Nakayama, Tokuzo Nishino, Tomokazu Matsue Menaquinone-specific prenyl reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus Journal of Bacteriology, 187 (2005) 1937-1944. Hisashi Hemmi, Yoshihiro Takahashi, Kyohei Shibuya, Toru Nakayama, and Tokuzo Nishino Microbial Diversity in Bio-Degradation and Re-utilization Processes of Garbage JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 99 (2005) 1-11. SHIN HARUTA, TORU NAKAYAMA, KOHEI NAKAMURA, HISASHI HEMMI, MASAHARU ISHII, YASUO IGARASHI, AND TOKUZO NISHINO 植物アシル基転移酵素ファミリー生化学,　77（2005）343-347. 中山　亨アントシアニングリコシル基転移酵素の進化と機能　特異性と普遍性化学と生物,　43 (2005) 142-145. 中山　亨イソプレノイド生合成酵素の分子解析化学と生物, 43 (2005) 296-304. 高橋征司、古山種俊 2004 Cold-active esterase from Psychrobacter sp. Ant300: gene cloning, characterization, and the effects of Gly->Pro substitution near the active site on its catalytic activity and stability Biochimica et Biophysica Acta, 1696 (2004), 59-65 Ljudmila Kulakova, Andrey Galkin, Toru Nakayama, Tokuzo Nishino, Nobuyoshi Esaki cDNA cloning and characterization of two Dendranthema x morifolium anthocyanin malonyltransferases with different functional activities Plant Science, 166 (2004), 89-96. Hirokazu Suzuki, Toru Nakayama, Masa-atsu Yamaguchi, Tokuzo Nishino Molecular Biological Analysis of Microflora in a Garbage Treatment Process under Thermoacidophilic Conditions JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 97 (2004), 119-126. HISASHI HEMMI, TAKEFUMI SHIMOYAMA, TORU NAKAYAMA, KATSUJI HOSHI AND TOKUZO NISHINO cDNA cloning and functional characterization of flavonol 3-O-glucoside-6''-O-malonyltransferases from flowers of Verbena hybrida and Lamium purpureum Journal of Molecular Catalysis B: Enzymatic, 28 (2004), 87-93. Hirokazu Suzuki, Toru Nakayama, Shiro Nagae, Masa-atsu Yamaguchi, Takashi Iwashita, Yuko Fukui, Tokuzo Nishino Type 2 isopentenyl diphosphate isomerase from a thermoacidophilic archaeon Sulfolobus shibatae European Journal of Biochemistry, 271 (2004), 1087-1093. Satoshi Yamashita, Hisashi Hemmi, Yosuke Ikeda, Toru Nakayama and Tokuzo Nishino Crystallographic and Biochemical Investigations of Kumamolisin-As, a Serine-Carboxyl Peptidase with Collagenase Activity The Journal of Biological Chemistry, 279 (2004), 21500-21510. Alexander Wlodawer, Mi Li, Alla Gustchina, Naoki Tsuruoka, Masako Ashida, Hiroyuki Minakata, Hiroshi Oyama, Kohei Oda, Tokuzo Nishino, and Toru Nakayama Identification and characterization of a novel anthocyanin malonyltransferase from scarlet sage (Salvia splendens) flowers: an enzyme that is phylogenetically separated from other anthocyanin acyltransferases The Plant Journal, 38 (2004), 994-1003. Hirokazu Suzuki, Shin’ya Sawada, Kazufumi Watanabe, Shiro Nagae, Masa-atsu Yamaguchi, Toru Nakayama, and Tokuzo Nishino Catalytic mechanism of type 2 isopentenyl diphosphate: dimethylallyl diphosphate isomerase: verification of a redox role of the flavin cofactor in a reaction with no net redox change Biochemical and Biophysical Research Communications, 322 (2004), 905-910. Hisashi Hemmi, Yosuke Ikeda, Satoshi Yamashita, Toru Nakayama and Tokuzo Nishino Molecular Cloning and Characterization of a Thermostable Carboxylesterase from an Archaeon, Sulfolobus shibatae DSM5389: Non-Linear Kinetic Behavior of a Hormone-Sensitive Lipase Family Enzyme JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 98 (2004), 445-451. KOKI EJIMA, JIAN LIU, YASUHIRO OSHIMA, KAZUTAKE HIROOKA, SHOKO SHIMANUKI, YUKAKO YOKOTA, HISASHI HEMMI, TORU NAKAYAMA, AND TOKUZO NISHINO (S)-2,3-Di-O-geranylgeranylglyceryl Phosphate Synthase from the Thermoacidophilic Archaeon Sulfolobus solfataricus: Molecular Cloning and Characterization of a Membrane-intrinsic Prenyltransferase Involved in the Biosynthesis of Archaeal Ether-linked Membrane Lipids The Journal of Biological Chemistry, 279 (2004), 50197-50203. Hisashi Hemmi, Kyohei Shibuya, Yoshihiro Takahashi, Toru Nakayama, and Tokuzo Nishino 身近な酵素の新しい素顔　次々と明らかにされるポリフェノールオキシダーゼの新しい役割化学, 59 (2004), 55-56 中山　亨 Monitoring the expression profiles of genes induced by hyperosmotic, high salinity, and oxidative stress and abscisic acid treatment in Arabidopsis cell culture using a full-length cDNA microarray Plant Molecular Biology, 56 (2004) 29-55. Seiji Takahashi, Motoaki Seki, Junko Ishida, Masakazu Satou, Tetsuya Sakurai, Mari Narusaka, Asako Kamiya, Maiko Nakajima, Akiko Enju, Kenji Akiyama, Kazuko Yamaguchi-Shinozaki, and Kazuo Shinozaki In vitro interaction between the human dehydrodolichyl diphosphate synthase and the Nieman-Pick C2 protein revealed by a yeast two-hybrid system Biochemical and Biophysical research Communications, 318 (2004) 198-203. Yugesh Kharel, Seiji Takahashi, Satoshi Yamashita, Tanetoshi Koyama 2003 Collagenolytic Serine-Carboxyl Proteinase from Alicyclobacillus sendaiensis Strain NTAP-1: Purification, Characterization, Gene Cloning, and Heterologous Expression APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 69 (2003), 162-169. Naoki Tsuruoka, Toru Nakayama, Masako Ashida, Hisashi Hemmi, Masahiro Nakao, Hiroyuki Minakata, Hiroshi Oyama, Kohei Oda, and Tokuzo Nishino Proposed Mechanism and Functional Amino Acid Residues of Malonyl-CoA:Anthocyanin 5-O-Glucoside-6''-O-Malonyltransferase from Flowers of Salvia Splendens, a Member of the Versatile Plant Acyltransferase Family Biochemistry, 42 (2003), 1764-1771. Hirokazu Suzuki, Toru Nakayama, and Tokuzo Nishino Alicyclobacillus sendaiensis sp. nov., a novel acidophilic, slightly thermophilic species isolated from soil in Sendai, Japan International Journal of Systematic and Evolutionary Microbiology, 53 (2003), 1081-1084. Naoki Tsuruoka, Yuri Isono, Osamu Shida, Hisashi Hemmi, Toru Nakayama, and Tokuzo Nishino Improvement of thermostability of cold-active serine alkaline protease from the psychrotrophic bacterium Shewanella sp. strain Ac10 by rational mutagenesis Journal of Molecular Catalysis B: Enzymatic, 22 (2003), 113-117. Ljudmila Kulakova, Andrey Galkin, Toru Nakayama, Tokuzo Nishino, Nobuyoshi Esaki Cloning, heterologous expression, renaturation, and characterization of a cold-adapted esterase with unique primary structure from a psychrotroph Pseudomonas sp. strain B11-1 Protein Expression and Purification, 30 (2003), 171-178. Takeshi Suzuki, Toru Nakayama, Dong Wong Choo, Yuriko Hirano, Tatsuo Kurihara, Tokuzo Nishino, and Nobuyoshi Esaki Fusion-type lycopene β-cyclase from a thermoacidophilic archaeon Sulfolobus solfataricus Biochemical and Biophysical Research Communications, 305 (2003), 586-591. Hisashi Hemmi, Satoru Ikejiri, Toru Nakayama, and Tokuzo Nishino Altering the substrate chain-length specificity of an α-glucosidase Biochemical and Biophysical Research Communications, 304 (2003), 684-690. Akio Noguchi, Toru Nakayama, Hisashi Hemmi, and Tokuzo Nishino An alternative mechanism of product chain-length determination in type III geranylgeranyl diphosphate synthase European Journal of Biochemistry, 270 (2003), 2186-2194. Hisashi Hemmi, Motoyoshi Noike, Toru Nakayama and Tokuzo Nishino Identification of a cDNA Encoding Malonyl-Coenzyme A:Anthocyanidin 3-O-Glucoside 6”-O-Malonyltransferase from Cineraria (Senecio cruentus) Flowers Plant Biotechnology, 20 (2003), 229-234. Hirokazu SUZUKI, Shin-ya SAWADA, Keiko YONEKURA-SAKAKIBARA, Toru NAKAYAMA, Masa-atsu YAMAGUCHI, and Tokuzo NISHINO Deciphering the Molecular Basis of the Broad Substrate Specificity of α-Glucosidase from Bacillus sp. SAM1606 Journal of Biochemistry, 134 (2003), 543-550. Akio Noguchi, Masayasu Yano, Yasuhiro Ohshima, Hisashi Hemmi, Misa Inohara-Ochiai, Maki Okada, Kyong-Son Min, Toru Nakayama and Tokuzo Nishino Acidulocomposting, an Accelerated Composting Process of Garbage under Thermoacidophilic Conditions for Prolonged Periods Journal of Environmental Biotechnology (環境バイオテクノロジー学会誌), 3 (2003), 33-36. TOKUZO NISHINO, TORU NAKAYAMA, HISASHI HEMMI, TAKEFUMI SHIMOYAMA, SATOSHI YAMASHITA, MINORU AKAI, TAKAHIRO KANAGAWA and KATSUJI HOSHI 花色発現をつかさどるポリフェノールオキシダーゼの酵素科学日本農芸化学会誌 77, (2003), 421-424. 中山　亨 Anthocyanin acyltransferases: specificities, mechanism, phylogenetics, and applications Journal of Molecular Catalysis B: Enzymatic, 23 (2003), 117-132. Toru Nakayama, Hirokazu Suzuki, Tokuzo Nishino Molecular Cloning, Expression and Characterization of cDNA Encoding cis-Prenyltransferases from Hevea brasiliensis - A key factor participating in natural rubber biosynthesis European Journal of Biochemistry, 270 (2003) 4671-4680. Kasem Asawatreratanakul, Yuan-Wei Zhang, Dhirayos Wititsuwannakul, Rapepun Wititsuwannakul, Seiji Takahashi, Atiya Rattanapittayaporn, Tanetoshi Koyama Isolation and expression of Paracoccus denitrificans decaprenyl diphosphate synthase gene for production of ubiquinone-10 in Escherichia coli Biochemical Engineering Journal, 16 (2003) 183-190. Seiji Takahashi, Tokuzo Nishino, Tanetoshi Koyama Identification of human dehydrodolichyl diphosphate synthase gene Biochimica et Biophysica Acta, 1625 (2003) 291-295. Shota Endo, Yuan-Wei Zhang, Seiji Takahashi, Tanetoshi Koyama Cloning, expression and characterization of a functional cDNA clone encoding geranylgeranyl diphosphate synthase of Hevea brasiliensis Biochimica et Biophysica Acta, 1625 (2003) 214-220. Akiyuki Takaya, Yuan-Wei Zhang, Kasem Asawatreratanakul, Dhirayos Wititsuwannakul, Rapepun Wititsuwannakul, Seiji Takahashi, Tanetoshi Koyama プレニル鎖延長酵素の遺伝子解明研究からみた天然ゴム生合成の分子解析日本ゴム協会誌, 76（2003）446-452 高橋征司、古山種俊 2002 cDNA Cloning, Heterologous Expressions, and Functional Characterization of Malonyl-CoA:Anthocyanidin 3-O-Glucoside-6"-O-Malonyltransferase from Dahlia variabilis Flowers Plant Physiology, 130 (2002), 2142-2151. Hirokazu Suzuki, Toru Nakayama, Keiko Yonekura-Sakakibara, Yuko Fukui, Noriko Nakamura, Masa-atsu Yamaguchi, Yoshikazu Tanaka, Takaaki Kusumi, and Tokuzo Nishino Site-specific mutagenesis at positions 272 and 273 of the Bacillus sp. SAM1606 α-glucosidase to screen mutants with altered specificity for oligosaccharide production by transglucosylation Journal of Molecular Catalysis B: Enzymatic, 16 (2002), 265-274. Maki Okada, Toru Nakayama, Akio Noguchi, Masayasu Yano, Hisashi Hemmi, Tokuzo Nishino, Takashi Ueda A cold-active esterase with a substrate preference for vinyl esters from a psychrotroph, Acinetobacter sp. strain No.6: gene cloning, purification, and characterization Journal of Molecular Catalysis B: Enzymatic, 16 (2002), 255-263. Takeshi Suzuki, Toru Nakayama, Tatsuo Kurihara, Tokuzo Nishino, Nobuyoshi Esaki Primary Structure and Catalytic Properties of a Cold-active Esterase from a Psychrotroph, Acinetobacter sp. Strain No.6 Isolated from Siberian Soil Bioscience, Biotechnology, and Biochemistry, 66 (2002), 1682-1690. Takeshi SUZUKI, Toru NAKAYAMA, Tatsuo KURIHARA, Tokuzo NISHINO, and Nobuyoshi ESAKI Deletion and Insertion of a 192-Residue Peptide in the Active-Site Domain of Glycosyl Hydrolase Family-2 β-Galactosidases JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 93 (2002), 575-583. MISA INOHARA-OCHIAI, SATOSHI HASEGAWA, SOTA IGUCHI, TOSHIHIKO ASHIKARI, YUJI SHIBANO, HISASHI HEMMI, TORU NAKAYAMA, AND TOKUZO NISHINO Novel Sugar Phosphotransferase System Applicable to the Efficient Labeling of the Compounds Synthesized via the Non-Mevalonate Pathway in Escherichia coli JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 93 (2002), 515-518. HISASHI HEMMI, SATOSHI YAMASHITA, TORU NAKAYAMA, AND TOKUZO NISHINO Hsc62, Hsc56, and GrpE, the third Hsp70 chaperone system of Escherichia coli Biochemical and Biophysical Research Communications, 293 (2002), 1389-1385. Kazuaki Yoshimune, Tohru Yoshimura, Toru Nakayama, Tokuzo Nishino, and Nobuyoshi Esaki Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations Biochemical and Biophysical Research Communications, 297 (2002), 1096-1101. Hisashi Hemmi, Motoyoshi Noike, Toru Nakayama, and Tokuzo Nishino Synthesis of Glucosyltrehaloses by a Thermostable α-Glucosidase with Broad Substrate Specificity and High Transglucosylation Activity: Assessment Using Wild-Type Enzyme and Mutants with Amino Acid Substitution near Active Site Journal of Japanese Society of Nutrition and Food Science, 55 (2002), 19-25. Maki Okada, Toru Nakayama, Akio Noguchi, Tokuzo Nishino, Yukiko Kan, Takashi Iwashita, and Takashi Ueda 生体触媒の新しい機能・特性の探索と解析生物工学会誌, 80 (2002), 111-117. 中山亨 Enzymology of Aurone Biosynthesis JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 94 (2002), 487-491. TORU NAKAYAMA 2001 Malonyl-CoA:Anthocyanin 5-O-Glucoside-6'''-O-Malonyltransferase from Scarlet Sage (Salvia splendens) Flowers ENZYME PURIFICATION, GENE CLONING, EXPRESSION, AND CHARACTERIZATION The Journal of Biological Chemistry, 276 (2001), 49013-49019. Hirokazu Suzuki, Toru Nakayama, Keiko Yonekura-Sakakibara, Yuko Fukui, Noriko Nakamura, Masahiro Nakao,　Yoshikazu Tanaka, Masa-atsu Yamaguchi, Takaaki Kusumi, and Tokuzo Nishino Cloning, Expression, and Characterization of cis-Polyprenyl Diphosphate Synthase from the Thermoacidophilic Archaeon Sulfolobus acidocaldarius JOURNAL OF BACTERIOLOGY, 183 (2001), 401-404. HISASHI HEMMI, SATOSHI YAMASHITA, TAKEFUMI SHIMOYAMA, TORU NAKAYAMA, AND TOKUZO NISHINO Enzymatic formation of aurones in the extracts of yellow snapdragon flowers Plant Science, 160 (2001), 229-236. Takuya Sato, Toru Nakayama, Sanae Kikuchi, Yuko Fukui, Keiko Yonekura-Sakakibara, Takashi Ueda, Tokuzo Nishino, Yoshikazu Tanaka, Takaaki Kusumi Cloning and rational mutagenesis of kexstatin I, a potent proteinaceous inhibitor of Kex2 proteinase Biochemical Journal, 355 (2001), 339-346. Kohei ODA, Hiroshi OYAMA, Satoshi ITO, Momoko FUKIHARU, Yu MIYAGAWA, Saori TAKAHASHI, Mika HIROSE, Norihisa KIKUCHI, Toru NAKAYAMA and Yuji SHIBANO Specificity analysis and mechanism of aurone synthesis catalyzed by aureusidin synthase, a polyphenol oxidase homolog responsible for flower coloration FEBS Letters, 499 (2001), 107-111. Toru Nakayama, Takuya Sato, Yuko Fukui, Keiko Yonekura-Sakakibara, Hideyuki Hayashi, Yoshikazu Tanaka, Takaaki Kusumi, Tokuzo Nishino Cold-Active Lipolytic Activity of Psychrotrophic Acinetobacter sp. Strain No. 6 JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 92 (2001), 144-148. TAKESHI SUZUKI, TORU NAKAYAMA, TATSUO KURIHARA, TOKUZO NISHINO, AND NOBUYOSHI ESAKI 生ごみのアシドロコンポスト化と酵素による支援バイオサイエンスとインダストリー, 59 (2001), 98-101. 中山亨　西野徳三アシドロコンポスト化：臭気発生のほとんどない新しいコンポスト化プロセス臭気の研究, 32 (2001), 210-216. 中山亨　西野徳三「黄色い」花を作る第一歩　明らかになったオーロン生合成経路と植物ポリフェノールオキシダーゼの新しい役割化学と生物, 39 (2001), 564-565．中山亨，田中良和 An essential role of a TatC homologue of a pH-dependent protein transporter in thylakoid membrane formation during chloroplast development in Arabidopsis thaliana Proceedings of the National Academy of Sciences of the United States of America, 98 (2001) 10499-10504. Reiko Motohashi, Noriko Nagata, Takuya Ito, Seiji Takahashi, Tokunori Hobo,　Shigeo Yoshida, and Kazuo Shinozaki Involvement of a novel Arabidopsis phospholipase D, AtPLD, in dehydration-inducible accumulation of phosphatidic acid in stress signaling The Plant Journal, 26 (2001) 595-605. Takeshi Katagiri, Seiji Takahashi, and Kazuo Shinozaki Hyperosmotic stress induces a rapid and transient increase in inositol 1,4,5-trisphosphate independent of abscisic acid in Arabidopsis cell culture Plant and Cell Physiology, 42 (2001) 214-222. Seiji Takahashi, Takeshi Katagiri, Takashi Hirayama, Kazuko Yamaguchi-Shinozaki and Kazuo Shinozaki 2000 Aureusidin Synthase: A Polyphenol Oxidase Homolog Responsible for Flower Coloration Science, 290 (2000), 1163-1166. T. Nakayama, K. Yonekura-Sakakibara, T. Sato, S. Kikuchi, Y. Fukui, M. Fukuchi-Mizutani, T. Ueda, M. Nakao, Y. Tanaka, T. Kusumi, T. Nishino Purification and inactivation by substrate of an allene oxide synthase (CYP74) from corn (Zea mays L.) seeds Phytochemistry, 53 (2000), 319-323. Yukiko Utsunomiya, Toru Nakayama, Hideo Oohira, Rie Hirota, Terutoshi Mori, Fusako Kawai, Takashi Ueda HPLC Analysis and Optimization of Enzymatic Synthesis of 4'-O-(β-D-Glucopyranosyl)-D-Pantothenic Acid Journal of Nutritional Science and Vitaminology, 46 (2000), 101-104. Maki OKADA, Miho KYOGUCHI, Toru NAKAYAMA, Rie HIROTA, Teruo AMACHI and Takashi UEDA Thermostable Collagenolytic Activity of a Novel Thermophilic Isolate, Bacillus sp. Strain NTAP-1 JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 89 (2000), 612-614. TORU NAKAYAMA, NAOKI TSURUOKA, MINORU AKAI, AND TOKUZO NISHINO Zinc biosorption by a zinc-resistant bacterium, Brevibacterium sp. strain HZM-1 Applied Microbiology and Biotechnology, 54 (2000), 581-588. J. Taniguchi ・ H. Hemmi ・ K. Tanahashi ・ N. Amano ・ T. Nakayama ・ T. Nishino An Active-Site Mutation Causes Enhanced Reactivity and Altered Regiospecificity of Transglucosylation Catalyzed by the Bacillus sp. SAM1606 α-Glucosidase JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 89 (2000), 431-437. MISA INOHARA-OCHIAI, MAKI OKADA, TORU NAKAYAMA, HISASHI HEMMI, TAKASHI UEDA, TAKASHI IWASHITA, YUKIKO KAN, YUJI SHIBANO, TOSHIHIKO ASHIKARI, AND TOKUZO NISHINO Mutational Analysis of the Role of His452 of Saccharopolyspora rectivirgula β-Galactosidase JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 90 (2000), 535-539. TORU NAKAYAMA, YUKA GOTO, SATOSHI HASEGAWA, MISA INOHARA-OCHIAI, YUJI SHIBANO, TOSHIHIKO ASHIKARI, AND TOKUZO NISHINO Molecular and functional characterization of a rose lipoxygenase cDNA related to flower senescence Plant Science, 160 (2000), 129-137. Masako Fukuchi-Mizutani, Kanako Ishiguro, Toru Nakayama, Yukiko Utsunomiya, Yoshikazu Tanaka, Takaaki Kusumi, Takashi Ueda An Arabidopsis gene encoding a Ca2+-binding protein is induced by abscisic acid during dehydration Plant and Cell Physiology, 41 (2000) 898-903. Seiji Takahashi, Takeshi Katagiri, Kazuko Yamaguchi-Shinozaki and Kazuo Shinozaki 1999 Purification, characterization, and application of an acid urease from Arthrobacter mobilis Journal of Biotechnology, 68 (1999), 227-236. Katsuro Miyagawa, Motoo Sumida, Masahiro Nakao, Masami Harada, Hiroshi Yamamoto, Takaaki Kusumi, Kiyoshi Yoshizawa, Teruo Amachi, Toru Nakayama Fungal peroxidase: its structure, function, and application Journal of Molecular Catalysis B: Enzymatic, 6 (1999), 185-198. Toru Nakayama, Teruo Amachi 微生物β-ガラクトシダーゼの分子酵素学とその応用 TOBIN, No. 18 (1999), 37-41. 中山亨 Isolation of an Arabidopsis thaliana cDNA encoding a pleckstrin homology domain protein, a putative homologue of human plackstrin Journal of Experimental Botany, 50 (1999) 729-730. Koji Mikami, Seiji Takahashi, Takeshi Katagiri, Kazuko Yamaguchi-Shinozaki and Kazuo Shinozaki 1998 Unique primary structure of a thermostable multimetal β-galactosidase from Saccharopolyspora rectivirgula Biochimica et Biophysica Acta, 1388 (1998), 77-83. Misa Inohara-Ochiai, Toru Nakayama, Masahiro Nakao, Tsuyoshi Fujita, Takashi Ueda, Toshihiko Ashikari, Tokuzo Nishino, Yuji Shibano 広範な基質特異性を有するα-グルコシダーゼとそのトレハロース認識に関わるアミノ酸残基応用糖質科学 (Oyo Toshitsu Kagaku: J. Appl. Glycosci.), 45 (1998), 185-197. 中山　亨，落合美佐，中尾正宏，後藤理枝子，上田隆史，柴野裕次 1997 Altering Substrate Specificity of Bacillus sp. SAM1606 α-Glucosidase by Comparative Site-specific Mutagenesis The Journal of Biological Chemistry, 272 (1997), 1601-1607. Misa Inohara-Ochiai, Toru Nakayama, Rieko Goto, Masahiro Nakao, Takashi Ueda, and Yuji Shibano 微生物β-ガラクトシダーゼ：その酵素学と食品工学的利用 New Food Industry, 39 (1997), 58-64. 中山亨　上田隆史 1996 好熱性放線菌Saccharopolyspora rectivirgula の耐熱性マルチメタルβ-ガラクトシダーゼの機能と構造応用糖質科学 (Oyo Toshitsu Kagaku: J. Appl. Glycosci.), 43 (1996), 237-245. 中山亨, 落合美佐, 中尾正宏, 原田雅己, 上田隆史, 柴野裕次 β-ガラクトシダーゼ研究の進展生物工学会誌, 74 (1996), 135. 中山亨 1995 Visible Light-Sensitized Oxidation of Arachidonic Acid in the Presence of Inperatorin Journal of Nutritional Science and Vitaminology, 41 (1995), 387-393. Yuka FUKUI, Mayumi MORITA, Kazuko OSAKADA, Toru NAKAYAMA, Masakazu MATSUOKA, Rie HIROTA, Hisako IIZUMI, and Takashi UEDA Visible Spectrophotometric Assay, Purification, and Molecular Properties of a Lipoxygenase from Eggplant (Solanum melongena Linne) Fruits BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 214 (1995), 1067-1072. Toru Nakayama, Yuriko Takeura, and Takashi Ueda Structures of genomic and complementary DNAs coding for Pleurotus ostreatus manganese (II) peroxidase Biochimica et Biophysica Acta, 1251 (1995), 205-209. Yasuhiko Asada, Akira Watanabe, Toshikazu Irie, Toru Nakayama, Masaaki Kuwahara Cloning, Sequencing, and Heterologous Expression of a Gene Coding for Arthromyces ramosus Peroxidase Bioscience, Biotechnology, and Biochemistry, 59 (1995), 1221-1228. Haruyo SAWAI-HATANAKA, Toshihiko ASHIKARI, Yoshikazu TANAKA, Yasuhiko ASADA, Toru NAKAYAMA, Hiroyuki MINAKATA, Naoki KUNISHIMA, Keiichi FUKUYAMA, Hideaki YAMADA, Yuji SHIBANO, and Teruo AMACHI 1994 Purification and characterization of a thermostable β-galactosidase with high transgalactosylation activity from Saccharopolyspora rectivirgula Applied Microbiology and Biotechnology, 40 (1994), 657-663. Masahiro Nakao, Masami Harada, Yukiko Kodama, Toru Nakayama, Yuji Shibano, Teruo Amachi Purification and characterization of a Bacillus sp. SAM1606 thermostable α-glucosidase with high transglucosylation activity Applied Microbiology and Biotechnology, 40 (1994), 337-343. M. Nakao ・ T. Nakayama ・ M. Harada ・ A. Kakudo ・ H. Ikemoto ・ S. Kobayashi ・ Y. Shibano Structure and expression of a gene coding for thermostable α-glucosidase with a broad substrate specificity from Bacillus sp. SAM1606 European Journal of Biochemistry, 220 (1994), 293-300. Masahiro NAKAO, Toru NAKAYAMA, Akemi KAKUDO, Misa INOHARA, Masami HARADA, Fumihiko OMURA, and Yuji SHIBANO Oxidation-Reduction Properties of Compounds I and II of Arthromyces ramosus Peroxidase Biochemistry, 33 (1994), 5647-5652. Z. Shadi Farhangrazi, Bruce R. Copeland, Toru Nakayama, Teruo Amachi, Isao Yamazaki, and L. S. Powers Divalent Metal Ion Requirements of a Thermostable Multimetal β-Galactosidase from Saccharopolyspora rectivirgula The Journal of Biological Chemistry, 269 (1994), 22021-22026. Masami Harada, Misa Inohara, Masahiro Nakao, Toru Nakayama, Akemi Kakudo, Yuji Shibano, and Teruo Amachi 1983-1993 Purification and Characterization of Endogeneous Protein Activator of Human Platelet Proteasome Journal of Biochemistry, 114 (1993), 317-323. Masao Yukawa, Masato Sakon, Jun-ichi Kambayashi, Ei-ichi Shiba, Tomio Kawasaki, Yoshio Uemura, Kohei Murata, Takaharu Tanaka, Toru Nakayama, Hiroshi Shibata, and Takesada Mori 目で見るバイオ　微生物ペルオキシダーゼと化学発光バイオサイエンスとバイオインダストリー, 50 (1992), 7-8. 中山亨・天知輝夫微生物ペルオキシダーゼの性質とその応用バイオサイエンスとインダストリー, 50 (1992), 442-444. 中山亨・天知輝夫 A Novel Trehalase Inhibitor, Trehalostatin, Produced by Amycolatopsis trehalostatica HG-25 Agricultural and Biological Chemistry, 55 (1991), 895-897. Sawao MURAO, Takafumi SAKAI, Hideki GIBO, Toru NAKAYAMA and Takashi SHIN Structure of Trehalostatin: A Potent and Specific Inhibitor of Trehalase Journal of Chemical Society Chemical Communications, Issue 14 (1991), 919-921. Toru Nakayama, Teruo Amachi, Sawao Murao, Takafumi Sakai, Takashi Shin, Peter T. M. Kenny, Takashi Iwashita, Michael Zagorski, Hajime Komura and Kyosuke Nomoto トレハロース，トレハラーゼ，トレハラーゼ阻害剤醗酵工学, 69 (1991), 273-247. 中山亨 Specific Labeling of the Essential Cysteine Residue of L-Methionine γ-Lyase with a Cofactor Analogue, N-(Bromoacetyl)pyridoxamine Phosphate Biochemistry, 27 (1988), 1587-1591. Toru Nakayama, Nobuyoshi Esaki, Hidehiko Tanaka, and Kenji Soda Chemical Modification of Cysteine Residues of L-Methionine γ-Lyase Agricultural and Biological Chemistry, 52 (1988), 177-183. Toru NAKAYAMA, Nobuyoshi ESAKI, Hidehiko TANAKA and Kenji SODA Catalytic Action of L-Methionine γ-Lyase on 4-Azaleucine Agricultural and Biological Chemistry, 51 (1987), 3159-3160. Setsuo FURUYOSHI, Toru NAKAYAMA, Nobuyoshi ESAKI, Hidehiko TANAKA and Kenji SODA Synthesis of Labeled (±)-2-Amino-3-butenoic Acids Journal of Organic Chemistry, 51 (1986), 3384-3386. Seiji Sawada, Thoru Nakayama, Nobuyoshi Esaki, Hidehiko Tanaka, Kenji Soda, and Richard K. Hill L-Methionine gγ-lyaseの酵素自殺基質反応：S-(N-methylthio carbamoyl)-L-cysteineによる不活性化とその機構含硫アミノ酸 (Sulfur Amino Acids), 9 (1986), 281-283. 江崎信芳, 木村富美夫, 後藤譲治, 中山亨, 田中英彦, 左右田健次 1H NMR Studies of Substrate Hydrogen Exchange Reactions Catalyzed by L-Methionine γ-Lyase Biochemistry, 24 (1985), 3857-3862. Nobuyoshi Esaki, Toru Nakayama, Seiji Sawada, Hidehiko Tanaka, and Kenji Soda Purification of Bacterial L-Methionine γ-Lyase ANALYTICAL BIOCHEMISTRY, 138 (1984), 421-424. TORU NAKAYAMA, NOBUYOSHI ESAKI, KUNIO SUGIE, TEMIR T. BERESOV, HIDEHIKO TANAKA, AND KENJI SODA S-(N-METHYLTHIOCARBAMOYL)-L-CYSTEINE, A SUICIDE SUBSTRATE OF L-METHIONINE γ-LYASE Biochimica et Biophysica Acta, 785 (1984), 54-60. NOBUYOSHI ESAKI, TOMIO KIMURA, JOJI GOTO, TORU NAKAYAMA, HIDEHIKO TANAKA and KENJI SODA Reactions of O-Substituted L-Homoserines Catalyzed by L-Methionine γ-Lyase and Their Mechanism Agricultural and Biological Chemistry, 48 (1984), 1991-1996. Nobuyoshi ESAKI, Toru NAKAYAMA, Seiji SAWADA, Hidehiko TANAKA and Kenji SODA Purification and Properties of L-Methionine g-Lyase from Aeromonas sp. Agricultural and Biological Chemistry, 48 (1984), 2367-2369. Toru NAKAYAMA, Nobuyoshi ESAKI, Woon-Joo LEE, Izumi TANAKA, Hidehiko TANAKA and Kenji SODA 光学活性含セレンアミノ酸の合成含硫アミノ酸 (Sulfur Amino Acids), 7 (1984), 221-224. PATRIC CHOCAT, 中山亨, 江崎信芳, 田中英彦, 左右田健次 L-Methionine γ-Lyase: 精製方法の改良とサブユニット構造含硫アミノ酸 (Sulfur Amino Acids), 6 (1983), 175-178. 中山亨, 江崎信芳, 与那覇和雄, 田中英彦, 左右田健次		Plant Cell First published on August 6, 2010

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